Self-reported impairment of the joints in patients with moderate hemophilia
. | 1972 . | 1978 . | 1985 . | 1992 . | 2001 . |
|---|---|---|---|---|---|
| Aged 0-16 y | |||||
| Median joint score* (range) | 0 (0-10) | 0 (0-6) | 0 (0-14) | 0 (0-8) | 0 (0-7) |
| Severe joint impairment, proportion of patients (%)† | 5/42 (12) | 2/41 (5) | 1/59 (2) | — | 1/46 (2) |
| Aged 17-25 y | |||||
| Median joint score* (range) | 2 (0-9) | 1 (0-7) | 1 (0-8) | 1 (1-5) | 1 (0-10) |
| Severe joint impairment, proportion of patients (%) | 1/14 (7) | — | 1/22 (5) | — | 1/23 (4) |
| Aged 25-40 y | |||||
| Median joint score* (range) | 5 (0-27) | 7 (0-17) | 3 (0-20) | 3 (0-12) | 4 (0-16) |
| Severe joint impairment, proportion of patients (%) | 2/18 (11) | 6/24 (25) | 10/58 (17) | 8/45 (18) | 6/35 (17) |
| Older than 40 y of age | |||||
| Median joint score* (range) | 4 (0-10) | 3 (0-15) | 5 (0-24) | 6 (0-24) | 5 (0-44) |
| Severe joint impairment, proportion of patients (%) | 3/9 (33) | 3/15 (20) | 6/36 (17) | 16/53 (30) | 23/72 (32) |
| Overall | |||||
| Median joint score* (range) | 1 (0-27) | 1 (0-17) | 1 (0-24) | 2 (0-24) | 2 (0-44) |
| Severe joint impairment, proportion of patients (%) | 11/83 (13) | 11/95 (10) | 18/157 (10) | 24/173 (14) | 31/176 |
. | 1972 . | 1978 . | 1985 . | 1992 . | 2001 . |
|---|---|---|---|---|---|
| Aged 0-16 y | |||||
| Median joint score* (range) | 0 (0-10) | 0 (0-6) | 0 (0-14) | 0 (0-8) | 0 (0-7) |
| Severe joint impairment, proportion of patients (%)† | 5/42 (12) | 2/41 (5) | 1/59 (2) | — | 1/46 (2) |
| Aged 17-25 y | |||||
| Median joint score* (range) | 2 (0-9) | 1 (0-7) | 1 (0-8) | 1 (1-5) | 1 (0-10) |
| Severe joint impairment, proportion of patients (%) | 1/14 (7) | — | 1/22 (5) | — | 1/23 (4) |
| Aged 25-40 y | |||||
| Median joint score* (range) | 5 (0-27) | 7 (0-17) | 3 (0-20) | 3 (0-12) | 4 (0-16) |
| Severe joint impairment, proportion of patients (%) | 2/18 (11) | 6/24 (25) | 10/58 (17) | 8/45 (18) | 6/35 (17) |
| Older than 40 y of age | |||||
| Median joint score* (range) | 4 (0-10) | 3 (0-15) | 5 (0-24) | 6 (0-24) | 5 (0-44) |
| Severe joint impairment, proportion of patients (%) | 3/9 (33) | 3/15 (20) | 6/36 (17) | 16/53 (30) | 23/72 (32) |
| Overall | |||||
| Median joint score* (range) | 1 (0-27) | 1 (0-17) | 1 (0-24) | 2 (0-24) | 2 (0-44) |
| Severe joint impairment, proportion of patients (%) | 11/83 (13) | 11/95 (10) | 18/157 (10) | 24/173 (14) | 31/176 |
Median joint score over 16 joints (min = 0, max = 48) and severe joint impairment in the left and right ankle, elbow and knee joints.
— indicates not present.
The median joint score was calculated as the median over the sum of the scores of 16 joints, which have been scored as follows: 0 indicates no impairment; 1, some impairment; 2, some impairment with daily problems; and 3, severe impairment with total loss of function.
Severe impairment with total loss of function reported in one or more of the six main joints.