Self-reported impairment of the joints in patients with severe hemophilia
. | 1972 . | 1978 . | 1985 . | 1992 . | 2001 . |
|---|---|---|---|---|---|
| Aged 0-16 y | |||||
| Median joint score (range)* | 1 (0-19) | 1 (0-25) | 1 (0-10) | 0 (0-7) | 0 (0-33) |
| Severe joint impairment, proportion of patients (%)† | 7/65 (11) | 8/92 (9) | 4/111 (4) | 1/92 (1) | 4/130 (3) |
| Aged 17-25 y | |||||
| Median joint score (range)* | 5 (0-16) | 4 (0-25) | 3 (0-19) | 3 (0-12) | 3 (0-13) |
| Severe joint impairment, proportion of patients (%)† | 9/39 (23) | 12/54 (22) | 11/84 (13) | 12/64 (19) | 8/42 (19) |
| Aged 25-40 y | |||||
| Median joint score (range)* | 10 (2-13) | 9 (0-22) | 8 (0-31) | 7 (0-28) | 5 (0-24) |
| Severe joint impairment, proportion of patients (%)† | 22/39 (56) | 21/69 (30) | 41/115 (36) | 42/119 (35) | 30/89 (34) |
| Older than 40 y of age | |||||
| Median joint score (range)* | 12 (4-26) | 11 (3-41) | 12 (0-42) | 12 (0-40) | 15 (0-48) |
| Severe joint impairment, proportion of patients (%)† | 11/16 (69) | 16/30 (53) | 44/74 (60) | 63/113 (56) | 102/159 (64) |
| Overall | |||||
| Median joint score (range)* | 5 (0-26) | 5 (0-41) | 5 (0-42) | 6 (0-40) | 5 (0-48) |
| Severe joint impairment, proportion of patients (%)† | 49/159 (31) | 57/245 (23) | 100/384 (26) | 118/388 (30) | 144/420 (34) |
. | 1972 . | 1978 . | 1985 . | 1992 . | 2001 . |
|---|---|---|---|---|---|
| Aged 0-16 y | |||||
| Median joint score (range)* | 1 (0-19) | 1 (0-25) | 1 (0-10) | 0 (0-7) | 0 (0-33) |
| Severe joint impairment, proportion of patients (%)† | 7/65 (11) | 8/92 (9) | 4/111 (4) | 1/92 (1) | 4/130 (3) |
| Aged 17-25 y | |||||
| Median joint score (range)* | 5 (0-16) | 4 (0-25) | 3 (0-19) | 3 (0-12) | 3 (0-13) |
| Severe joint impairment, proportion of patients (%)† | 9/39 (23) | 12/54 (22) | 11/84 (13) | 12/64 (19) | 8/42 (19) |
| Aged 25-40 y | |||||
| Median joint score (range)* | 10 (2-13) | 9 (0-22) | 8 (0-31) | 7 (0-28) | 5 (0-24) |
| Severe joint impairment, proportion of patients (%)† | 22/39 (56) | 21/69 (30) | 41/115 (36) | 42/119 (35) | 30/89 (34) |
| Older than 40 y of age | |||||
| Median joint score (range)* | 12 (4-26) | 11 (3-41) | 12 (0-42) | 12 (0-40) | 15 (0-48) |
| Severe joint impairment, proportion of patients (%)† | 11/16 (69) | 16/30 (53) | 44/74 (60) | 63/113 (56) | 102/159 (64) |
| Overall | |||||
| Median joint score (range)* | 5 (0-26) | 5 (0-41) | 5 (0-42) | 6 (0-40) | 5 (0-48) |
| Severe joint impairment, proportion of patients (%)† | 49/159 (31) | 57/245 (23) | 100/384 (26) | 118/388 (30) | 144/420 (34) |
Median joint score over 16 joints (min = 0, max = 48) and severe joint impairment in the left and right ankle, elbow, and knee joints.
The median joint score was calculated as the median over the sum of the scores of 16 joints, which have been scored as follows: 0 indicates no impairment; 1, some impairment; 2, some impairment with daily problems; and 3, severe impairment with total loss of function.
Severe impairment with total loss of function reported in 1 or more of the 6 main joints.