Table 4. Characteristics and outcome of... | American Society of Hematology

Table 4.

Characteristics and outcome of HSCT in 38 patients with MLL⁺ ALL

	WBC count, × 10⁹	HSCT							Conditioning regimen	GVHD prophylaxis
Age, mo/gender	WBC count, × 10⁹		Type	Status	HLA*	Time, mo†			Conditioning regimen	GVHD prophylaxis	Outcome
5/F	260	UCBT	CR1	4/6	4	BU	CSA	CCR
6/M	21	UCBT	CR1	5/6	5	TBI	CSA	CCR
7/F	24	UCBT	CR1	5/6	4	BU	FK	CCR
7/F	668	UCBT	CR1	5/6	5	TBI	FK	CCR
6/F	420	UCBT	CR1	5/6	6	TBI	CSA	CCR
4/F	7	UCBT	CR1	5/6	4	TBI	CSA	Rel‡
11/M	119	UCBT	CR1	6/6	5	TBI	FK	CCR
4/F	5	UCBT	CR1	5/6	6	TBI	CSA	Rel§
6/M	39	UCBT	CR1	5/6	5	BU	CSA	CCR
4/M	1000	UCBT	CR1	4/6	5	BU	CSA	Fail″
5/M	26	UCBT	CR1	6/6	6	BU	CSA	CCR
1/M	39	UBMT	CR1	6/6	5	TBI	FK	CCR
3/F	143	RPBSCT	CR1	5/6	7	BU	CSA	Rel§
7/F	2	UCBT	CR1	4/6	8	TBI	FK	CCR
2/F	48	RBMT	CR1	6/6	5	BU	CSA	CCR
4/M	552	UCBT	CR1	5/6	6	TBI	FK	Rel‡
4/F	35	RBMT	CR1	4/6	4	TBI	FK	CCR
6/M	1524	UBMT	CR1	6/6	6	BU	FK	CCR
11/F	299	UCBT	CR1	5/6	5	BU	CSA	CCR
9/F	251	UCBT	CR1	4/6	3	TBI	FK	D¶
9/F	732	RBMT	CR1	6/6	4	TBI	CSA	Rel‡
3/M	54	UCBT	CR1	5/6	5	TBI	FK	Rel#
7/M	1252	UCBT	CR1	6/6	6	BU	CSA	Rel#
1/M	44	UCBT	CR1	5/6	6	TBI	FK	D¶
10/M	31	UBMT	CR1	6/6	8	Other	FK	CCR
4/F	23	UCBT	CR1	5/6	5	BU	FK	CCR
11/F	143	RBMT	CR1	5/6	5	TBI	CSA	CCR
4/F	50	RPBSCT	CR1	5/6	5	BU	FK	CCR
7/M	124	UCBT	CR1	4/6	6	BU	CSA	CCR
6/M	47	UCBT	CR2	6/6	4	TBI	CSA	Rel#
3/F	288	UCBT	CR2	5/6	5	TBI	CSA	CCR
0/M	24	UCBT	CR2	5/6	3	BU	FK	D¶
3/F	134	UCBT	IF	4/6	4	TBI	CSA	Rel‡
4/F	225	RBMT	Rel	6/6	8	BU	CSA	CCR
7/F	11	UCBT	Rel	5/6	6	TBI	CSA	Rel§
2/M	54	RBMT	Rel	5/6	11	Other	FK	Rel‡
2/F	188	UBMT	Rel	6/6	5	BU	FK	Rel‡
1/M	900	UCBT	Rel	6/6	5	TBI	FK	Rel‡

	WBC count, × 10⁹	HSCT							Conditioning regimen	GVHD prophylaxis
Age, mo/gender	WBC count, × 10⁹		Type	Status	HLA*	Time, mo†			Conditioning regimen	GVHD prophylaxis	Outcome
5/F	260	UCBT	CR1	4/6	4	BU	CSA	CCR
6/M	21	UCBT	CR1	5/6	5	TBI	CSA	CCR
7/F	24	UCBT	CR1	5/6	4	BU	FK	CCR
7/F	668	UCBT	CR1	5/6	5	TBI	FK	CCR
6/F	420	UCBT	CR1	5/6	6	TBI	CSA	CCR
4/F	7	UCBT	CR1	5/6	4	TBI	CSA	Rel‡
11/M	119	UCBT	CR1	6/6	5	TBI	FK	CCR
4/F	5	UCBT	CR1	5/6	6	TBI	CSA	Rel§
6/M	39	UCBT	CR1	5/6	5	BU	CSA	CCR
4/M	1000	UCBT	CR1	4/6	5	BU	CSA	Fail″
5/M	26	UCBT	CR1	6/6	6	BU	CSA	CCR
1/M	39	UBMT	CR1	6/6	5	TBI	FK	CCR
3/F	143	RPBSCT	CR1	5/6	7	BU	CSA	Rel§
7/F	2	UCBT	CR1	4/6	8	TBI	FK	CCR
2/F	48	RBMT	CR1	6/6	5	BU	CSA	CCR
4/M	552	UCBT	CR1	5/6	6	TBI	FK	Rel‡
4/F	35	RBMT	CR1	4/6	4	TBI	FK	CCR
6/M	1524	UBMT	CR1	6/6	6	BU	FK	CCR
11/F	299	UCBT	CR1	5/6	5	BU	CSA	CCR
9/F	251	UCBT	CR1	4/6	3	TBI	FK	D¶
9/F	732	RBMT	CR1	6/6	4	TBI	CSA	Rel‡
3/M	54	UCBT	CR1	5/6	5	TBI	FK	Rel#
7/M	1252	UCBT	CR1	6/6	6	BU	CSA	Rel#
1/M	44	UCBT	CR1	5/6	6	TBI	FK	D¶
10/M	31	UBMT	CR1	6/6	8	Other	FK	CCR
4/F	23	UCBT	CR1	5/6	5	BU	FK	CCR
11/F	143	RBMT	CR1	5/6	5	TBI	CSA	CCR
4/F	50	RPBSCT	CR1	5/6	5	BU	FK	CCR
7/M	124	UCBT	CR1	4/6	6	BU	CSA	CCR
6/M	47	UCBT	CR2	6/6	4	TBI	CSA	Rel#
3/F	288	UCBT	CR2	5/6	5	TBI	CSA	CCR
0/M	24	UCBT	CR2	5/6	3	BU	FK	D¶
3/F	134	UCBT	IF	4/6	4	TBI	CSA	Rel‡
4/F	225	RBMT	Rel	6/6	8	BU	CSA	CCR
7/F	11	UCBT	Rel	5/6	6	TBI	CSA	Rel§
2/M	54	RBMT	Rel	5/6	11	Other	FK	Rel‡
2/F	188	UBMT	Rel	6/6	5	BU	FK	Rel‡
1/M	900	UCBT	Rel	6/6	5	TBI	FK	Rel‡

CR1 indicates first remission; FK, FK506; Rel, relapse; Fail, failure of transplantation; D, death; CR2, second remission; IF, induction failure. Other abbreviations are explained in the text and Tables 1 and 2.

HLA results: 6/6, complete match; 5/6, 1-locus mismatch; 4/6, 2-loci mismatch.

†

Time from diagnosis to HSCT.

‡

Death due to disease progression without second HSCT.

Death due to disease progression after second HSCT.

″

Toxic death after second HSCT.

Toxic death without second HSCT.

CCR after second HSCT.

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