Table 5.

Response after PBSCT




No.

Response, %

Stable, %

Not evaluated, %
Neurologic  16   87   0   13  
Subjective   16   87   0   13  
Nerve conduction studies at 1 y   11   36   9   55  
Neuropathy impairment score   16*  25   12   56  
Hematologic  16   56   6   37  
Nonsecretory   3   NA   NA   100  
Immunofixation only   7   43   14   43  
SPEP evaluable   6   100  0   0  
Organ  11   82   0   18  
Hepatomegaly   5   60   0   40  
Splenomegaly   10   50   20   30  
Lymphadenopathy   7   71   29   0  
Extravascular volume overload  14   79   0   21  
Ascites   6   83   0   17  
Effusion   4   100   0   0  
Edema   14   79   0   21  
Dermatologic   13   54   15   31  
Papilledema   4   50   0   50  
Endocrine   13   23   8   69  
Pulmonary
 
15
 
20
 
0
 
80
 



No.

Response, %

Stable, %

Not evaluated, %
Neurologic  16   87   0   13  
Subjective   16   87   0   13  
Nerve conduction studies at 1 y   11   36   9   55  
Neuropathy impairment score   16*  25   12   56  
Hematologic  16   56   6   37  
Nonsecretory   3   NA   NA   100  
Immunofixation only   7   43   14   43  
SPEP evaluable   6   100  0   0  
Organ  11   82   0   18  
Hepatomegaly   5   60   0   40  
Splenomegaly   10   50   20   30  
Lymphadenopathy   7   71   29   0  
Extravascular volume overload  14   79   0   21  
Ascites   6   83   0   17  
Effusion   4   100   0   0  
Edema   14   79   0   21  
Dermatologic   13   54   15   31  
Papilledema   4   50   0   50  
Endocrine   13   23   8   69  
Pulmonary
 
15
 
20
 
0
 
80
 

Median follow-up was 10.8 months. One patient died before evaluation and another patient has not yet returned for evaluation. SPEP indicates serum protein electrophoresis.

*

One patient showed borderline worsening at 15 months. At 24 months, the patient reported substantial improvement; no repeat neuropathy impairment score was performed.

Two complete responses, 3 very good partial responses, and 1 minimal response.

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