Response after PBSCT
. | No. . | Response, % . | Stable, % . | Not evaluated, % . |
---|---|---|---|---|
Neurologic | 16 | 87 | 0 | 13 |
Subjective | 16 | 87 | 0 | 13 |
Nerve conduction studies at 1 y | 11 | 36 | 9 | 55 |
Neuropathy impairment score | 16* | 25 | 12 | 56 |
Hematologic | 16 | 56 | 6 | 37 |
Nonsecretory | 3 | NA | NA | 100 |
Immunofixation only | 7 | 43 | 14 | 43 |
SPEP evaluable | 6 | 100† | 0 | 0 |
Organ | 11 | 82 | 0 | 18 |
Hepatomegaly | 5 | 60 | 0 | 40 |
Splenomegaly | 10 | 50 | 20 | 30 |
Lymphadenopathy | 7 | 71 | 29 | 0 |
Extravascular volume overload | 14 | 79 | 0 | 21 |
Ascites | 6 | 83 | 0 | 17 |
Effusion | 4 | 100 | 0 | 0 |
Edema | 14 | 79 | 0 | 21 |
Dermatologic | 13 | 54 | 15 | 31 |
Papilledema | 4 | 50 | 0 | 50 |
Endocrine | 13 | 23 | 8 | 69 |
Pulmonary | 15 | 20 | 0 | 80 |
. | No. . | Response, % . | Stable, % . | Not evaluated, % . |
---|---|---|---|---|
Neurologic | 16 | 87 | 0 | 13 |
Subjective | 16 | 87 | 0 | 13 |
Nerve conduction studies at 1 y | 11 | 36 | 9 | 55 |
Neuropathy impairment score | 16* | 25 | 12 | 56 |
Hematologic | 16 | 56 | 6 | 37 |
Nonsecretory | 3 | NA | NA | 100 |
Immunofixation only | 7 | 43 | 14 | 43 |
SPEP evaluable | 6 | 100† | 0 | 0 |
Organ | 11 | 82 | 0 | 18 |
Hepatomegaly | 5 | 60 | 0 | 40 |
Splenomegaly | 10 | 50 | 20 | 30 |
Lymphadenopathy | 7 | 71 | 29 | 0 |
Extravascular volume overload | 14 | 79 | 0 | 21 |
Ascites | 6 | 83 | 0 | 17 |
Effusion | 4 | 100 | 0 | 0 |
Edema | 14 | 79 | 0 | 21 |
Dermatologic | 13 | 54 | 15 | 31 |
Papilledema | 4 | 50 | 0 | 50 |
Endocrine | 13 | 23 | 8 | 69 |
Pulmonary | 15 | 20 | 0 | 80 |
Median follow-up was 10.8 months. One patient died before evaluation and another patient has not yet returned for evaluation. SPEP indicates serum protein electrophoresis.
One patient showed borderline worsening at 15 months. At 24 months, the patient reported substantial improvement; no repeat neuropathy impairment score was performed.
Two complete responses, 3 very good partial responses, and 1 minimal response.