Hematologic and extrahematologic toxicity
. | MEL 100 of patients ages 65-70* . | MEL 100 of patients ages 50-70* . | MP of patients ages 50-70* . |
|---|---|---|---|
| No. | 43 | 93 | 92 |
| Duration of neutropenia†, d, range (median) | 1-13 (5) | 0-13 (5) | — |
| Duration of thrombocytopenia†, d, range (median) | 0-18 (3) | 0-18 (3) | — |
| Patients who required platelet transfusion, no. (%) | 18 (41) | 50 (54) | 2 (2) |
| Patients who required red blood cell transfusion, no. (%) | 21 (48) | 50 (54) | 3 (3) |
| Unknown origin fever, no. (%) | 9 (20) | 29 (31) | 0 (0) |
| Mucositis, no. (%)‡ | 14 (32) | 21 (23) | 0 (0) |
| Viral infections, no. (%)‡ | 2 (4) | 6 (6) | 0 (0) |
| Pneumonia, no. (%) | 4 (9) | 6 (7) | 0 (0) |
| Cardiac toxicity, no. (%)‡ | 0 (0) | 2 (2) | 2 (2) |
| Pulmonary toxicity, no. (%)‡ | 0 (0) | 1 (1) | 0 (0) |
| Renal toxicity grade, no. (%)‡ | 1 (2) | 2 (2) | 0 (0) |
| Gastrointestinal toxicity, no. (%)‡ | 3 (7) | 8 (9) | 0 (0) |
| Neurologic toxicity, no. (%)‡ | 0 (0) | 0 (0) | 1 (1) |
| Sepsis, no (%) | 2 (4) | 2 (2) | 1 (1) |
| Central venous catheter infection, no. (%) | 0 (0) | 2 (2) | — |
| Thromboembolism, no. (%) | 0 (0) | 1 (1) | 3 (3) |
| At least one organ toxicity, no. (%) | 10 (23) | 28 (30) | 7 (8) |
. | MEL 100 of patients ages 65-70* . | MEL 100 of patients ages 50-70* . | MP of patients ages 50-70* . |
|---|---|---|---|
| No. | 43 | 93 | 92 |
| Duration of neutropenia†, d, range (median) | 1-13 (5) | 0-13 (5) | — |
| Duration of thrombocytopenia†, d, range (median) | 0-18 (3) | 0-18 (3) | — |
| Patients who required platelet transfusion, no. (%) | 18 (41) | 50 (54) | 2 (2) |
| Patients who required red blood cell transfusion, no. (%) | 21 (48) | 50 (54) | 3 (3) |
| Unknown origin fever, no. (%) | 9 (20) | 29 (31) | 0 (0) |
| Mucositis, no. (%)‡ | 14 (32) | 21 (23) | 0 (0) |
| Viral infections, no. (%)‡ | 2 (4) | 6 (6) | 0 (0) |
| Pneumonia, no. (%) | 4 (9) | 6 (7) | 0 (0) |
| Cardiac toxicity, no. (%)‡ | 0 (0) | 2 (2) | 2 (2) |
| Pulmonary toxicity, no. (%)‡ | 0 (0) | 1 (1) | 0 (0) |
| Renal toxicity grade, no. (%)‡ | 1 (2) | 2 (2) | 0 (0) |
| Gastrointestinal toxicity, no. (%)‡ | 3 (7) | 8 (9) | 0 (0) |
| Neurologic toxicity, no. (%)‡ | 0 (0) | 0 (0) | 1 (1) |
| Sepsis, no (%) | 2 (4) | 2 (2) | 1 (1) |
| Central venous catheter infection, no. (%) | 0 (0) | 2 (2) | — |
| Thromboembolism, no. (%) | 0 (0) | 1 (1) | 3 (3) |
| At least one organ toxicity, no. (%) | 10 (23) | 28 (30) | 7 (8) |