Meta-analyses of MTHFR C677T homozygosity versus noncarriers on ICD and VTE
Study . | Studies, no. . | Cases, no. . | Controls, no. . | End point . | OR (95% CI) . |
|---|---|---|---|---|---|
| ICD | |||||
| Brattström, 19989 | 17 | 4 654 | 5 224 | IHD | 1.1 (0.9-1.4) |
| Wald, 20022 | 46 | 12 193 | 11 945 | IHD | 1.2 (1.1-1.4) |
| Klerk, 200211 | 40 | 11 162 | 12 758 | IHD | 1.2 (1.1-1.3) |
| Case-control | 35 | 9 874 | 11 009 | IHD | 1.2 (1.1-1.3) |
| Nested case-control | 5 | 1 288 | 1 749 | IHD | 0.9 (0.7-1.1) |
| European | 22 | 6 207 | 8 343 | IHD | 1.1 (1.0-1.4) |
| North American | 10 | 3 146 | 2 532 | IHD | 0.9 (0.7-1.0) |
| Wald, 20022 | 7 | 1 217 | Not reported | ICVD | 1.3 (0.8-2.2) |
| Kelly, 20024 | 19 | 2 950 | 4 187 | ICVD | 1.2 (1.0-1.6) |
| VTE | |||||
| Brattström, 20008 | 15 | 2 683 | 3 306 | DVT/PE | 1.1 (0.9-1.3) |
| Wald, 20022 | 26 | 3 439 | 5 063 | DVT/PE | 1.3 (1.1-1.5) |
Study . | Studies, no. . | Cases, no. . | Controls, no. . | End point . | OR (95% CI) . |
|---|---|---|---|---|---|
| ICD | |||||
| Brattström, 19989 | 17 | 4 654 | 5 224 | IHD | 1.1 (0.9-1.4) |
| Wald, 20022 | 46 | 12 193 | 11 945 | IHD | 1.2 (1.1-1.4) |
| Klerk, 200211 | 40 | 11 162 | 12 758 | IHD | 1.2 (1.1-1.3) |
| Case-control | 35 | 9 874 | 11 009 | IHD | 1.2 (1.1-1.3) |
| Nested case-control | 5 | 1 288 | 1 749 | IHD | 0.9 (0.7-1.1) |
| European | 22 | 6 207 | 8 343 | IHD | 1.1 (1.0-1.4) |
| North American | 10 | 3 146 | 2 532 | IHD | 0.9 (0.7-1.0) |
| Wald, 20022 | 7 | 1 217 | Not reported | ICVD | 1.3 (0.8-2.2) |
| Kelly, 20024 | 19 | 2 950 | 4 187 | ICVD | 1.2 (1.0-1.6) |
| VTE | |||||
| Brattström, 20008 | 15 | 2 683 | 3 306 | DVT/PE | 1.1 (0.9-1.3) |
| Wald, 20022 | 26 | 3 439 | 5 063 | DVT/PE | 1.3 (1.1-1.5) |
OR indicates odds ratios; and CI, confidence interval.