Odds ratios for IHD and ICVD by MTHFR C677T genotype in case-control studies
. | IHD . | . | ICVD . | . | ||
|---|---|---|---|---|---|---|
. | Odds ratio (95% CI) . | Trend test, P . | Odds ratio (95% CI) . | Trend test, P . | ||
| Unadjusted | ||||||
| Noncarriers | 1.0 | .84 | 1.0 | .72 | ||
| Heterozygotes | 0.9 (0.8-1.0) | .84 | 1.0 (0.8-1.1) | .72 | ||
| Homozygotes | 1.1 (0.9-1.3) | .84 | 1.0 (0.8-1.3) | .72 | ||
| Adjusted for age and sex | ||||||
| Noncarriers | 1.0 | .66 | 1.0 | .83 | ||
| Heterozygotes | 0.9 (0.8-1.0) | .66 | 1.0 (0.8-1.2) | .83 | ||
| Homozygotes | 1.0 (0.9-1.3) | .66 | 1.0 (0.7-1.3) | .83 | ||
. | IHD . | . | ICVD . | . | ||
|---|---|---|---|---|---|---|
. | Odds ratio (95% CI) . | Trend test, P . | Odds ratio (95% CI) . | Trend test, P . | ||
| Unadjusted | ||||||
| Noncarriers | 1.0 | .84 | 1.0 | .72 | ||
| Heterozygotes | 0.9 (0.8-1.0) | .84 | 1.0 (0.8-1.1) | .72 | ||
| Homozygotes | 1.1 (0.9-1.3) | .84 | 1.0 (0.8-1.3) | .72 | ||
| Adjusted for age and sex | ||||||
| Noncarriers | 1.0 | .66 | 1.0 | .83 | ||
| Heterozygotes | 0.9 (0.8-1.0) | .66 | 1.0 (0.8-1.2) | .83 | ||
| Homozygotes | 1.0 (0.9-1.3) | .66 | 1.0 (0.7-1.3) | .83 | ||
Odds ratios with 95% confidence intervals (CI) were calculated with noncarriers versus heterozygotes or homozygotes using unconditional logistic regression. P values are for trend tests, from noncarriers to heterozygotes to homozygotes. There were 2125 cases of IHD, 836 cases of ICVD, and 7568 controls.