Hazard ratios for IHD, ICVD, intermittent claudication, DVT, and PE by MTHFR C677T genotype in prospective studies
. | Ischemic cardiovascular disease . | . | . | . | . | . | Venous thromboembolism . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | IHD . | . | ICVD . | . | Intermittent claudication . | . | DVT . | . | PE . | . | ||||||||
. | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | ||||||||
| Sex and age adjustment | ||||||||||||||||||
| Noncarriers | 1.0 | .99 | 1.0 | .04 | 1.0 | .37 | 1.0 | .63 | 1.0 | .64 | ||||||||
| Heterozygotes | 1.0 (0.9-1.1) | .99 | 1.1 (0.9-1.4) | .04 | 1.2 (0.5-2.0) | .37 | 1.1 (0.8-1.6) | .63 | 0.9 (0.6-1.4) | .64 | ||||||||
| Homozygotes | 1.0 (0.8-1.2) | .99 | 1.4 (1.0-1.8) | .04 | 0.3 (0.03-2.0) | .37 | 0.9 (0.4-1.8) | .63 | 0.9 (0.4-1.8) | .64 | ||||||||
| Multifactorial adjustment* | ||||||||||||||||||
| Noncarriers | 1.0 | .51 | 1.0 | .12 | 1.0 | .39 | 1.0 | .78 | 1.0 | .61 | ||||||||
| Heterozygotes | 1.0 (0.9-1.1) | .51 | 1.1 (0.9-1.3) | .12 | 1.0 (0.5-2.0) | .39 | 1.2 (0.8-1.6) | .78 | 0.9 (0.6-1.4) | .61 | ||||||||
| Homozygotes | 0.9 (0.8-1.2) | .51 | 1.3 (0.9-1.8) | .12 | 0.3 (0.04-2.1) | .39 | 0.9 (0.5-1.8) | .78 | 0.8 (0.4-1.9) | .61 | ||||||||
. | Ischemic cardiovascular disease . | . | . | . | . | . | Venous thromboembolism . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | IHD . | . | ICVD . | . | Intermittent claudication . | . | DVT . | . | PE . | . | ||||||||
. | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | ||||||||
| Sex and age adjustment | ||||||||||||||||||
| Noncarriers | 1.0 | .99 | 1.0 | .04 | 1.0 | .37 | 1.0 | .63 | 1.0 | .64 | ||||||||
| Heterozygotes | 1.0 (0.9-1.1) | .99 | 1.1 (0.9-1.4) | .04 | 1.2 (0.5-2.0) | .37 | 1.1 (0.8-1.6) | .63 | 0.9 (0.6-1.4) | .64 | ||||||||
| Homozygotes | 1.0 (0.8-1.2) | .99 | 1.4 (1.0-1.8) | .04 | 0.3 (0.03-2.0) | .37 | 0.9 (0.4-1.8) | .63 | 0.9 (0.4-1.8) | .64 | ||||||||
| Multifactorial adjustment* | ||||||||||||||||||
| Noncarriers | 1.0 | .51 | 1.0 | .12 | 1.0 | .39 | 1.0 | .78 | 1.0 | .61 | ||||||||
| Heterozygotes | 1.0 (0.9-1.1) | .51 | 1.1 (0.9-1.3) | .12 | 1.0 (0.5-2.0) | .39 | 1.2 (0.8-1.6) | .78 | 0.9 (0.6-1.4) | .61 | ||||||||
| Homozygotes | 0.9 (0.8-1.2) | .51 | 1.3 (0.9-1.8) | .12 | 0.3 (0.04-2.1) | .39 | 0.9 (0.5-1.8) | .78 | 0.8 (0.4-1.9) | .61 | ||||||||
Adjusted for sex, age, and medians of cholesterol, high-density lipoprotein cholesterol, lipoprotein(a), fibrinogen, triglycerides, body mass index as well as smoking, diabetes mellitus, hypertension and factor V Leiden genotype. Hazard ratios with 95% confidence intervals (CI) was calculated for heterozygotes or homozygotes versus noncarriers using Cox regression. P values are for trend tests, from noncarriers to heterozygotes to homozygotes.