Description of study population
. | All . | Male . | Female . |
|---|---|---|---|
| Anthropometric data | |||
| No. of subjects | 12 | 6 | 6 |
| Age, y | 27.8 ± 1.8 | 28.3 ± 1.5 | 27.3 ± 2.07 |
| Weight, kg | 75.5 ± 14.8 | 85.8 ± 9.4 | 65.2 ± 11.8 |
| BMI, kg/m2 | 24.2 ± 2.6 | 25.0 ± 2.8 | 23.4 ± 2.4 |
| Biochemical markers at baseline | |||
| INR | 1.02 ± 0.07 | 1.04 ± 0.06 | 1.01 ± 0.08 |
| FIIc, % | 103 ± 11 | 103 ± 7 | 103 ± 15 |
| FVIIc, % | 109 ± 22 | 107 ± 18 | 110 ± 25 |
| ucFII, AU/mL | < 150 | < 150 | < 150 |
| ucOC, ng/mL | 3.4 ± 1.7 | 3.9 ± 1.6 | 3.0 ± 1.9 |
| cOC, ng/mL | 9.4 ± 3.4 | 10.7 ± 3.7 | 8.2 ± 2.8 |
| Vitamin K1, nM | 1.27 ± 0.4 | 1.36 ± 0.5 | 1.18 ± 0.5 |
| Vitamin K2, nM | ND | ND | ND |
| Triacylglycerol, mM | 1.02 ± 0.48 | 1.18 ± 0.59 | 0.87 ± 0.33 |
| OAC dose at stable anticoagulation, mg* | 3.1 ± 0.7 | 3.3 ± 0.7 | 2.8 ± 0.7 |
. | All . | Male . | Female . |
|---|---|---|---|
| Anthropometric data | |||
| No. of subjects | 12 | 6 | 6 |
| Age, y | 27.8 ± 1.8 | 28.3 ± 1.5 | 27.3 ± 2.07 |
| Weight, kg | 75.5 ± 14.8 | 85.8 ± 9.4 | 65.2 ± 11.8 |
| BMI, kg/m2 | 24.2 ± 2.6 | 25.0 ± 2.8 | 23.4 ± 2.4 |
| Biochemical markers at baseline | |||
| INR | 1.02 ± 0.07 | 1.04 ± 0.06 | 1.01 ± 0.08 |
| FIIc, % | 103 ± 11 | 103 ± 7 | 103 ± 15 |
| FVIIc, % | 109 ± 22 | 107 ± 18 | 110 ± 25 |
| ucFII, AU/mL | < 150 | < 150 | < 150 |
| ucOC, ng/mL | 3.4 ± 1.7 | 3.9 ± 1.6 | 3.0 ± 1.9 |
| cOC, ng/mL | 9.4 ± 3.4 | 10.7 ± 3.7 | 8.2 ± 2.8 |
| Vitamin K1, nM | 1.27 ± 0.4 | 1.36 ± 0.5 | 1.18 ± 0.5 |
| Vitamin K2, nM | ND | ND | ND |
| Triacylglycerol, mM | 1.02 ± 0.48 | 1.18 ± 0.59 | 0.87 ± 0.33 |
| OAC dose at stable anticoagulation, mg* | 3.1 ± 0.7 | 3.3 ± 0.7 | 2.8 ± 0.7 |
Values are the mean ± standard deviation.
ND indicates not detectable (< 0.05 nM).
The OAC dose at stable anticoagulation was the dose required to maintain the INR at a value of 2.0 ± 0.4.