Table 1. CDR3 characteristics of... | American Society of Hematology

Table 1.

CDR3 characteristics of sequences isolated from human LP-mouse chimeras, by source

	Adult, mean length ± SE (no.)	Cord blood, mean length ± SE (no.)	Fetal, mean length ± SE (no.)	ANOVA†	P
CDR3^*
sIgM^-	18.0 ± 0.6 (67)	15.4 ± 0.4 (154)	14.9 ± 0.6 (52)	F_{(2 270)} = 8.24	.0003
sIgM⁺	15.3 ± 0.4 (140)	14.5 ± 0.2 (385)	14.0 ± 0.2 (186)	F_{(2 708)} = 4.61	.0142
N nucleotide
sIgM^-	15.9 ± 1.1 (67)	13.4 ± 1.1 (70)	10.5 ± 1.3 (49)	F_{(2 183)} = 4.99	.0078
sIgM⁺	12 ± 0.6 (148)	13.3 ± 0.6 (179)	8.7 ± 0.6 (177)	F_{(2 501)} = 16.29	< .0001
V-DJ N nucleotides, sIgM^-	8.0 ± 0.8 (67)	7.1 ± 0.8 (40)	7.0 ± 1.0 (49)	F_{(2 153)} = 0.4343	.6485
D-J N nucleotides, sIgM^-	6.2 ± 0.6 (67)	6.9 ± 0.6 (40)	3.0 ± 0.7 (49)	F_{(2 153)} = 9.60	.0001

	Adult, mean length ± SE (no.)	Cord blood, mean length ± SE (no.)	Fetal, mean length ± SE (no.)	ANOVA†	P
CDR3^*
sIgM^-	18.0 ± 0.6 (67)	15.4 ± 0.4 (154)	14.9 ± 0.6 (52)	F_{(2 270)} = 8.24	.0003
sIgM⁺	15.3 ± 0.4 (140)	14.5 ± 0.2 (385)	14.0 ± 0.2 (186)	F_{(2 708)} = 4.61	.0142
N nucleotide
sIgM^-	15.9 ± 1.1 (67)	13.4 ± 1.1 (70)	10.5 ± 1.3 (49)	F_{(2 183)} = 4.99	.0078
sIgM⁺	12 ± 0.6 (148)	13.3 ± 0.6 (179)	8.7 ± 0.6 (177)	F_{(2 501)} = 16.29	< .0001
V-DJ N nucleotides, sIgM^-	8.0 ± 0.8 (67)	7.1 ± 0.8 (40)	7.0 ± 1.0 (49)	F_{(2 153)} = 0.4343	.6485
D-J N nucleotides, sIgM^-	6.2 ± 0.6 (67)	6.9 ± 0.6 (40)	3.0 ± 0.7 (49)	F_{(2 153)} = 9.60	.0001

Amino acids

ANOVA for all 3 age groups