Table 2.

Genes induced or repressed by GATA-1: 7 hours

Probe
Gene
Description
Function
0 h → 7 h
SLR
94747_at  Csf2rb1  Colony-stimulating factor 2 receptor, beta 1   Signaling   32 → 1466   5.8  
99922_at  Slc9a1  Solute carrier family 9, member 1   Membrane transporter   55 → 724   3.7  
94748_g_at  Csf2rb1  Colony-stimulating factor 2 receptor, beta 1   Signaling   111 → 1150   3.5  
104650_at  Ache  Acetylcholinesterase   Membrane glycoprotein   27 → 272   3.4  
103600_at  Epb4.9  Erythrocyte protein band 4.9   Cytoskeletal   26 → 260   3.3  
103210_at  Csf2rb2  Colony-stimulating factor 2 receptor, beta 2   Signaling   62 → 568   3.3  
94415_at  Bach1  BTB and CNC homology 1   Transcription factor   38 → 200   3.2  
104394_at  Abcb10  ATP-binding cassette, sub-family B, member 10   Heme metabolism   25 → 115   3.0  
97228_at  Lzf  Leucine zipper domain protein   Transcription factor?   125 → 1198   3.0  
160853_at  Ptdss2  Phosphatidylserine synthase 2   Membrane   90 → 919   2.6  
103085_at  Hebp  Heme-binding protein   Heme metabolism   121 → 677   2.5  
94438_at  Pfkm  Phosphofructokinase, muscle   Energy   189 → 1161   2.1  
97710_f_at  1110004B06Rik  RIKEN cDNA 1110004B06 gene   ?   278 → 992   2.0  
92286_g_at  Il4  Interleukin 4   Signaling   205 → 796   2.0  
99849_at  NO_GENE  VL30-like retrotransposon   Retrotransposon   537 → 2039   1.9  
92768_s_at  Alas2  Aminolevulinic acid synthase 2, erythroid   Heme metabolism   108 → 453   1.9  
93664_at  Atp1b2  ATPase, Na+/K+ transporting, beta 2 polypeptide   Membrane transporter   61 → 201   1.9  
98596_s_at  Siat9  Sialyltransferase 9   Glycoprotein synthesis   275 → 1086   1.9  
103773_at  1110020K19Rik  RIKEN cDNA 1110020K19 gene   ?   192 → 774   1.8  
104283_at  4432405K22Rik  RIKEN cDNA 4432405K22 gene   ?   129 → 521   1.7  
103471_at  4432405K22Rik  RIKEN cDNA 4432405K22 gene   ?   33 → 106   1.7  
94753_at  Gna15  Guanine nucleotide binding protein, alpha 15   Signaling   100 → 338   1.6  
101583_at  Btg2  B-cell translocation gene 2, antiproliferative   Transcription regulator   291 → 1253   1.6  
95052_at  1110035L05Rik  RIKEN cDNA 1110035L05 gene   ?   231 → 638   1.6  
103833_at  Hipk2  Homeodomain interacting protein kinase 2   Transcription regulator   85 → 207   1.6  
96353_at  1110021D01Rik  RIKEN cDNA 1110021D01 gene   ?   1553 → 4876   1.6  
101947_at  Nakap95-pending  Neighbor of A-kinase anchoring protein 95   ?   186 → 510   1.5  
102383_at  5730593F17Rik  RIKEN cDNA 5730593F17 gene   ?   348 → 596   1.5  
99535_at  NO_GENE  Intracisternal A—particle retrotransposon   Retrotransposon   355 → 905   1.5  
160225_at  Gtf2b  General transcription factor IIB   Transcription factor   409 → 1403   1.5  
101973_at  Cited2  Cbp/p300-interacting transactivator, Glu/Asp-rich C-term., 2   Transcription factor   343 → 101   -1.5  
93680_at  Stk10  Serine/threonine kinase 10   Signaling?   215 → 71   -1.6  
99109_at  Ier2  Immediate early response 2   Transcription factor   490 → 139   -1.6  
93793_at  Lasp1  LIM and SH3 protein 1   ?   259 → 72   -1.7  
98143_at  Fut8  Fucosyltransferase 8   Glycoprotein synthesis   305 → 75   -1.7  
99603_g_at  Tieg  TGFB inducible early growth response   Transcription factor   108 → 25   -1.9  
102318_at  Siat8d  Sialyltransferase 8 (alpha-2, 8-sialytransferase) D   Glycoprotein synthesis   121 → 30   -2.0  
161067_at  Ifld2  Induced in fatty liver dystrophy 2   Apoptosis pathway   236 → 59   -2.1  
102021_at  Il4ra  Interleukin 4 receptor, alpha   Signaling   142 → 30   -2.1  
102789_at  Gata2  GATA-binding protein 2   Transcription factor   1909 → 338   -2.2  
100467_at  Lyl1  Lymphoblastomic leukemia   Transcription factor   1638 → 259   -2.3  
100468_g_at  Lyl1  Lymphoblastomic leukemia   Transcription factor   3505 → 764   -2.3  
98500_at  Il1rl1  Interleukin 1-receptor—like 1   Signaling   222 → 38   -2.4  
100962_at  Nab2  Ngfi-A binding protein 2   Transcription factor   680 → 114   -2.5  
94419_at  Slc19a1  Solute carrier family 19, member 1   Membrane transporter   290 → 45   -2.6  
97473_at
 		Tm4sf7
 		 Transmembrane 4 superfamily member 7
 		 Membrane glycoprotein
 		 295 → 25
 		 -2.8
 
Probe
Gene
Description
Function
0 h → 7 h
SLR
94747_at  Csf2rb1  Colony-stimulating factor 2 receptor, beta 1   Signaling   32 → 1466   5.8  
99922_at  Slc9a1  Solute carrier family 9, member 1   Membrane transporter   55 → 724   3.7  
94748_g_at  Csf2rb1  Colony-stimulating factor 2 receptor, beta 1   Signaling   111 → 1150   3.5  
104650_at  Ache  Acetylcholinesterase   Membrane glycoprotein   27 → 272   3.4  
103600_at  Epb4.9  Erythrocyte protein band 4.9   Cytoskeletal   26 → 260   3.3  
103210_at  Csf2rb2  Colony-stimulating factor 2 receptor, beta 2   Signaling   62 → 568   3.3  
94415_at  Bach1  BTB and CNC homology 1   Transcription factor   38 → 200   3.2  
104394_at  Abcb10  ATP-binding cassette, sub-family B, member 10   Heme metabolism   25 → 115   3.0  
97228_at  Lzf  Leucine zipper domain protein   Transcription factor?   125 → 1198   3.0  
160853_at  Ptdss2  Phosphatidylserine synthase 2   Membrane   90 → 919   2.6  
103085_at  Hebp  Heme-binding protein   Heme metabolism   121 → 677   2.5  
94438_at  Pfkm  Phosphofructokinase, muscle   Energy   189 → 1161   2.1  
97710_f_at  1110004B06Rik  RIKEN cDNA 1110004B06 gene   ?   278 → 992   2.0  
92286_g_at  Il4  Interleukin 4   Signaling   205 → 796   2.0  
99849_at  NO_GENE  VL30-like retrotransposon   Retrotransposon   537 → 2039   1.9  
92768_s_at  Alas2  Aminolevulinic acid synthase 2, erythroid   Heme metabolism   108 → 453   1.9  
93664_at  Atp1b2  ATPase, Na+/K+ transporting, beta 2 polypeptide   Membrane transporter   61 → 201   1.9  
98596_s_at  Siat9  Sialyltransferase 9   Glycoprotein synthesis   275 → 1086   1.9  
103773_at  1110020K19Rik  RIKEN cDNA 1110020K19 gene   ?   192 → 774   1.8  
104283_at  4432405K22Rik  RIKEN cDNA 4432405K22 gene   ?   129 → 521   1.7  
103471_at  4432405K22Rik  RIKEN cDNA 4432405K22 gene   ?   33 → 106   1.7  
94753_at  Gna15  Guanine nucleotide binding protein, alpha 15   Signaling   100 → 338   1.6  
101583_at  Btg2  B-cell translocation gene 2, antiproliferative   Transcription regulator   291 → 1253   1.6  
95052_at  1110035L05Rik  RIKEN cDNA 1110035L05 gene   ?   231 → 638   1.6  
103833_at  Hipk2  Homeodomain interacting protein kinase 2   Transcription regulator   85 → 207   1.6  
96353_at  1110021D01Rik  RIKEN cDNA 1110021D01 gene   ?   1553 → 4876   1.6  
101947_at  Nakap95-pending  Neighbor of A-kinase anchoring protein 95   ?   186 → 510   1.5  
102383_at  5730593F17Rik  RIKEN cDNA 5730593F17 gene   ?   348 → 596   1.5  
99535_at  NO_GENE  Intracisternal A—particle retrotransposon   Retrotransposon   355 → 905   1.5  
160225_at  Gtf2b  General transcription factor IIB   Transcription factor   409 → 1403   1.5  
101973_at  Cited2  Cbp/p300-interacting transactivator, Glu/Asp-rich C-term., 2   Transcription factor   343 → 101   -1.5  
93680_at  Stk10  Serine/threonine kinase 10   Signaling?   215 → 71   -1.6  
99109_at  Ier2  Immediate early response 2   Transcription factor   490 → 139   -1.6  
93793_at  Lasp1  LIM and SH3 protein 1   ?   259 → 72   -1.7  
98143_at  Fut8  Fucosyltransferase 8   Glycoprotein synthesis   305 → 75   -1.7  
99603_g_at  Tieg  TGFB inducible early growth response   Transcription factor   108 → 25   -1.9  
102318_at  Siat8d  Sialyltransferase 8 (alpha-2, 8-sialytransferase) D   Glycoprotein synthesis   121 → 30   -2.0  
161067_at  Ifld2  Induced in fatty liver dystrophy 2   Apoptosis pathway   236 → 59   -2.1  
102021_at  Il4ra  Interleukin 4 receptor, alpha   Signaling   142 → 30   -2.1  
102789_at  Gata2  GATA-binding protein 2   Transcription factor   1909 → 338   -2.2  
100467_at  Lyl1  Lymphoblastomic leukemia   Transcription factor   1638 → 259   -2.3  
100468_g_at  Lyl1  Lymphoblastomic leukemia   Transcription factor   3505 → 764   -2.3  
98500_at  Il1rl1  Interleukin 1-receptor—like 1   Signaling   222 → 38   -2.4  
100962_at  Nab2  Ngfi-A binding protein 2   Transcription factor   680 → 114   -2.5  
94419_at  Slc19a1  Solute carrier family 19, member 1   Membrane transporter   290 → 45   -2.6  
97473_at
 		Tm4sf7
 		 Transmembrane 4 superfamily member 7
 		 Membrane glycoprotein
 		 295 → 25
 		 -2.8
 

Microarray results were filtered at an SLR of 1.5, P < .005, and threshold of 100 for the 7-hour time point versus time 0. The penultimate column indicates signal values for the indicated time points (average for triplicate experiments). 7 versus 0; SLR = 1.5; threshold = 100; P < .005.

? indicates unknown function.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal