CR, OS, and DFS rates as a function of clinical and biologic characteristics
. | No. (%) . | CRI, no. (%) [P] . | Overall CR, no. (%) [P] . | Median OS, mo. [P] . | Median DFS, mo. [P] . |
|---|---|---|---|---|---|
| Patients | 198 | 159 (80) | 170 (86) | 29 | 28 |
| Age | |||||
| Younger than 35 y | 110 (56) | 97 (88)§ | 104 (94)[<10-5] | 50.5 [.0019] | 37.2§ |
| 35 y or older | 88 (44) | 62 (70) | 66 (75) | 15.5 | 14.8 |
| WBC count | |||||
| Less than 30 × 109/L | 115 (58.1) | 92 (80)§ | 101 (88)§ | 51.6§ | 37.4§ |
| At least 30 × 109/L | 83 (41.9) | 67 (81) | 69 (89) | 19.1 | 16.8 |
| Cytogenetic results, no. = 174 | |||||
| Poor risk | 51 (29) | 32 (63) [.0002] | 36 (71) [< 10-4] | 14.9 [< 10-5] | 10.1 [.0021] |
| Others | 123 (71) | 107 (87) | 113 (92) | 71.8 | 70.0 |
| Ph∥ | 37∥ (21) | 20 (54) | 24 (67) | 14.8 | 8.8 |
| t(4;11) | 8 (5) | 6 (75) | 6 (75) | 5.6 | 5.8 |
| t(1;19) | 6 (3) | 6 (100) | 6 (100) | 30.2 | 10.1 |
| Complex | 22 (13) | 18 (82) | 19 (86) | 19 | 12.6 |
| Normal | 44 (25) | 40 (91) | 41 (93) | 71.8 | 70.0 |
| Others | 57 (33) | 49 (86) | 53 (93) | 72.7 | 70.8 |
| Immunophenotype | |||||
| B-ALL, total | 129 (77) | 104 (81)§ | 112 (87)§ | 27.7§ | 17.1§ |
| T-ALL, total | 35 (21) | 29 (83) | 31 (89) | 60.9 | 57.6 |
| B-ALL, subset* | 48 | NA | NA | 72.7 | 70.8 |
| T-ALL, subset† | 10 | NA | NA | 71.8 | 70 |
| No. induction cycles needed for CR | |||||
| 1 | 159 | NA | NA | 71.8 [.03] | 37.4§ |
| 2 | 11 | NA | NA | 23.3 | 13.1 |
| No. poor-risk factors at diagnosis‡ | |||||
| 0 | 1 | 1 (0) | 1 (100) | 25.3 [< 10-5] | 20.9 [< 10-5] |
| 1 | 81 (41) | 73 (90) | 77 (95) | 71.8 | 57.6 |
| 2 | 64 (32) | 53 (83) | 56 (86) | 38.4 | 70.8 |
| 3 | 36 (18) | 22 (61) | 25 (69) | 14.8 | 10.9 |
| 4 | 16 (8) | 11 (69) | 11 (69) | 9.9 | 6.4 |
| No. poor-risk factors after induction | |||||
| 1 | 74 (37) | 73 (99) | 74 (100) | 71.8 [< 10-5] | 70 [< 10-5] |
| 2 | 64 (32) | 53 (83) | 57 (89) | 72.7 | 70.8 |
| 3 | 30 (15) | 21 (70) | 24 (80) | 15.5 | 12.8 |
| 4 | 25 (13) | 11 (44) | 14 (56) | 9.7 | 5.6 |
| 5 | 5 (2) | 0 | 0 | 10.6 | NA |
. | No. (%) . | CRI, no. (%) [P] . | Overall CR, no. (%) [P] . | Median OS, mo. [P] . | Median DFS, mo. [P] . |
|---|---|---|---|---|---|
| Patients | 198 | 159 (80) | 170 (86) | 29 | 28 |
| Age | |||||
| Younger than 35 y | 110 (56) | 97 (88)§ | 104 (94)[<10-5] | 50.5 [.0019] | 37.2§ |
| 35 y or older | 88 (44) | 62 (70) | 66 (75) | 15.5 | 14.8 |
| WBC count | |||||
| Less than 30 × 109/L | 115 (58.1) | 92 (80)§ | 101 (88)§ | 51.6§ | 37.4§ |
| At least 30 × 109/L | 83 (41.9) | 67 (81) | 69 (89) | 19.1 | 16.8 |
| Cytogenetic results, no. = 174 | |||||
| Poor risk | 51 (29) | 32 (63) [.0002] | 36 (71) [< 10-4] | 14.9 [< 10-5] | 10.1 [.0021] |
| Others | 123 (71) | 107 (87) | 113 (92) | 71.8 | 70.0 |
| Ph∥ | 37∥ (21) | 20 (54) | 24 (67) | 14.8 | 8.8 |
| t(4;11) | 8 (5) | 6 (75) | 6 (75) | 5.6 | 5.8 |
| t(1;19) | 6 (3) | 6 (100) | 6 (100) | 30.2 | 10.1 |
| Complex | 22 (13) | 18 (82) | 19 (86) | 19 | 12.6 |
| Normal | 44 (25) | 40 (91) | 41 (93) | 71.8 | 70.0 |
| Others | 57 (33) | 49 (86) | 53 (93) | 72.7 | 70.8 |
| Immunophenotype | |||||
| B-ALL, total | 129 (77) | 104 (81)§ | 112 (87)§ | 27.7§ | 17.1§ |
| T-ALL, total | 35 (21) | 29 (83) | 31 (89) | 60.9 | 57.6 |
| B-ALL, subset* | 48 | NA | NA | 72.7 | 70.8 |
| T-ALL, subset† | 10 | NA | NA | 71.8 | 70 |
| No. induction cycles needed for CR | |||||
| 1 | 159 | NA | NA | 71.8 [.03] | 37.4§ |
| 2 | 11 | NA | NA | 23.3 | 13.1 |
| No. poor-risk factors at diagnosis‡ | |||||
| 0 | 1 | 1 (0) | 1 (100) | 25.3 [< 10-5] | 20.9 [< 10-5] |
| 1 | 81 (41) | 73 (90) | 77 (95) | 71.8 | 57.6 |
| 2 | 64 (32) | 53 (83) | 56 (86) | 38.4 | 70.8 |
| 3 | 36 (18) | 22 (61) | 25 (69) | 14.8 | 10.9 |
| 4 | 16 (8) | 11 (69) | 11 (69) | 9.9 | 6.4 |
| No. poor-risk factors after induction | |||||
| 1 | 74 (37) | 73 (99) | 74 (100) | 71.8 [< 10-5] | 70 [< 10-5] |
| 2 | 64 (32) | 53 (83) | 57 (89) | 72.7 | 70.8 |
| 3 | 30 (15) | 21 (70) | 24 (80) | 15.5 | 12.8 |
| 4 | 25 (13) | 11 (44) | 14 (56) | 9.7 | 5.6 |
| 5 | 5 (2) | 0 | 0 | 10.6 | NA |
CRI indicates complete remission after 1 induction course; CR, complete remission; DFS, disease-free survival; NA, not applicable.
WBC count below 30 × 109/L, no poor-risk cytogenetic factors in CR after the first induction course.
Patient older than 35 years without poor-risk cytogenetic factors in CR after the first induction course.
For this analysis, 1 patient with Philadelphia chromosome, no mediastinal involvement, but no immunophenotype at diagnosis was considered non-T lineage. In addition, patients without cytogenetic results were considered not to have t(9;22), t(1;19), or t(4;11).
P is nonsignificant.
Two patients with BCR-ABL transcripts were included despite failure for one and normal karyotype for the other.