Assessment of LAIPs in genetically defined subgroups of AML in an extended cohort
. | . | Log difference to normal bone marrow . | . | LAIP-positive cells in leukemic bone marrow, % . | . | LAIP-positive cells in normal bone marrow, % . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter . | No. . | Median . | Range . | Median . | Range . | Median . | Range . | |||
| Type of LAIP | ||||||||||
| Asynchronous | 73 | 2.82 | 1.70-4.16 | 11.74 | 3.09-58.80 | 0.02 | 0.00-0.18 | |||
| Cross-lineage | 143 | 3.20 | 1.72-4.21 | 19.60 | 3.26-83.61 | 0.01 | 0.00-0.36 | |||
| Lack of expression | 127 | 3.09 | 1.23-4.32 | 20.62 | 3.10-82.66 | 0.01 | 0.00-0.63 | |||
| Overexpression | 172 | 2.90 | 0.95-4.24 | 11.81 | 3.08-71.45 | 0.01 | 0.00-1.05 | |||
| Cytogenetic subtype | ||||||||||
| t(8;21) | 29 | 3.41 | 1.95-4.12 | 17.59 | 5.15-64.11 | 0.01 | 0.00-0.18 | |||
| t(11q23) | 10 | 2.98 | 2.17-4.21 | 23.27 | 5.79-64.53 | 0.02 | 0.00-0.10 | |||
| t(15;17) | 32 | 2.98 | 2.06-4.21 | 22.89 | 3.28-65.24 | 0.02 | 0.00-0.17 | |||
| Trisomy 8: sole | 17 | 2.79 | 1.83-3.82 | 20.84 | 5.24-66.09 | 0.02 | 0.00-0.31 | |||
| inv(16)/t(16;16) | 35 | 2.87 | 0.95-4.04 | 13.58 | 4.70-51.51 | 0.02 | 0.00-1.05 | |||
| Complex aberrant karyotype | 37 | 2.99 | 1.03-4.11 | 13.47 | 3.10-76.14 | 0.02 | 0.00-0.79 | |||
| Normal karyotype | 224 | 3.07 | 1.04-4.32 | 14.03 | 3.08-83.61 | 0.01 | 0.00-1.01 | |||
| Other cytogenetic aberrations | 131 | 3.05 | 1.56-4.17 | 16.04 | 3.08-71.55 | 0.01 | 0.00-0.63 | |||
| Genetic alteration | ||||||||||
| FLT3 length mutations | 13 | 3.00 | 2.16-3.80 | 13.09 | 3.21-71.45 | 0.01 | 0.00-0.09 | |||
| MLL partial tandem duplications | 5 | 3.01 | 1.63-3.07 | 10.58 | 9.09-42.05 | 0.01 | 0.01-0.22 | |||
| Total | 515 | 3.05 | 0.95-4.32 | 15.90 | 3.08-83.61 | 0.01 | 0.00-1.05 | |||
. | . | Log difference to normal bone marrow . | . | LAIP-positive cells in leukemic bone marrow, % . | . | LAIP-positive cells in normal bone marrow, % . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter . | No. . | Median . | Range . | Median . | Range . | Median . | Range . | |||
| Type of LAIP | ||||||||||
| Asynchronous | 73 | 2.82 | 1.70-4.16 | 11.74 | 3.09-58.80 | 0.02 | 0.00-0.18 | |||
| Cross-lineage | 143 | 3.20 | 1.72-4.21 | 19.60 | 3.26-83.61 | 0.01 | 0.00-0.36 | |||
| Lack of expression | 127 | 3.09 | 1.23-4.32 | 20.62 | 3.10-82.66 | 0.01 | 0.00-0.63 | |||
| Overexpression | 172 | 2.90 | 0.95-4.24 | 11.81 | 3.08-71.45 | 0.01 | 0.00-1.05 | |||
| Cytogenetic subtype | ||||||||||
| t(8;21) | 29 | 3.41 | 1.95-4.12 | 17.59 | 5.15-64.11 | 0.01 | 0.00-0.18 | |||
| t(11q23) | 10 | 2.98 | 2.17-4.21 | 23.27 | 5.79-64.53 | 0.02 | 0.00-0.10 | |||
| t(15;17) | 32 | 2.98 | 2.06-4.21 | 22.89 | 3.28-65.24 | 0.02 | 0.00-0.17 | |||
| Trisomy 8: sole | 17 | 2.79 | 1.83-3.82 | 20.84 | 5.24-66.09 | 0.02 | 0.00-0.31 | |||
| inv(16)/t(16;16) | 35 | 2.87 | 0.95-4.04 | 13.58 | 4.70-51.51 | 0.02 | 0.00-1.05 | |||
| Complex aberrant karyotype | 37 | 2.99 | 1.03-4.11 | 13.47 | 3.10-76.14 | 0.02 | 0.00-0.79 | |||
| Normal karyotype | 224 | 3.07 | 1.04-4.32 | 14.03 | 3.08-83.61 | 0.01 | 0.00-1.01 | |||
| Other cytogenetic aberrations | 131 | 3.05 | 1.56-4.17 | 16.04 | 3.08-71.55 | 0.01 | 0.00-0.63 | |||
| Genetic alteration | ||||||||||
| FLT3 length mutations | 13 | 3.00 | 2.16-3.80 | 13.09 | 3.21-71.45 | 0.01 | 0.00-0.09 | |||
| MLL partial tandem duplications | 5 | 3.01 | 1.63-3.07 | 10.58 | 9.09-42.05 | 0.01 | 0.01-0.22 | |||
| Total | 515 | 3.05 | 0.95-4.32 | 15.90 | 3.08-83.61 | 0.01 | 0.00-1.05 | |||