Comparison of IgH mutation in ton sillar intraepithelial B cells and atypical B cells of marginal zone hyperplasia
Lesion and type of cells examined . | No. of PCR clones studied . | No. of clones with identical VH* . | No. of clones with identical CDR3 . | No. of clones showing somatic mutation greater than 2% (%) . |
|---|---|---|---|---|
| Control tonsil | ||||
| Intraepithelial B cells | 9 | 2 (DP70) | 0 | 7 (3-7) |
| Case 2 | ||||
| MZ B cells | 10 | 2 (DP50) | 0 | 0 |
| Intraepithelial B cells | 9 | 0 | 0 | 1 (8.5) |
| Case 3 | ||||
| MZ B cells | 9 | 0 | 0 | 1 (4.9) |
| Intraepithelial B cells | 10 | 2 (DP50) | 0 | 1 (3.5) |
Lesion and type of cells examined . | No. of PCR clones studied . | No. of clones with identical VH* . | No. of clones with identical CDR3 . | No. of clones showing somatic mutation greater than 2% (%) . |
|---|---|---|---|---|
| Control tonsil | ||||
| Intraepithelial B cells | 9 | 2 (DP70) | 0 | 7 (3-7) |
| Case 2 | ||||
| MZ B cells | 10 | 2 (DP50) | 0 | 0 |
| Intraepithelial B cells | 9 | 0 | 0 | 1 (8.5) |
| Case 3 | ||||
| MZ B cells | 9 | 0 | 0 | 1 (4.9) |
| Intraepithelial B cells | 10 | 2 (DP50) | 0 | 1 (3.5) |
VH indicates variable region, heavy chain; and CDR3, complementarity-determining region 3.
VH family member used by the identical clone is indicated in parentheses.