Comparison of the immunophenotype of normal tonsillar IEBCs with the hyperplastic MZ B cells, colonized follicles, and IEBCs of the cases
Immunohistochemistry . | IRTA-1* . | CD43* . | CD21 . | BCL-2* . | CD27* . | Ki 67 . | IgM* . | IgD* . | Light chains . |
|---|---|---|---|---|---|---|---|---|---|
| Control tonsil IEBCs | + | + | + (weak) | + | + | High | + | + | Polytypic |
| Cases showing MZ hyperplasia with MZ B cells, colonized follicles, and IEBCs | + | + | + | + | − | High | + | + | λ restricted |
Immunohistochemistry . | IRTA-1* . | CD43* . | CD21 . | BCL-2* . | CD27* . | Ki 67 . | IgM* . | IgD* . | Light chains . |
|---|---|---|---|---|---|---|---|---|---|
| Control tonsil IEBCs | + | + | + (weak) | + | + | High | + | + | Polytypic |
| Cases showing MZ hyperplasia with MZ B cells, colonized follicles, and IEBCs | + | + | + | + | − | High | + | + | λ restricted |
IEBCs indicates intraepithelial B cells; MZ, marginal zone; IRTA-1, immunoglobulin superfamily receptor translocated-associated 1; IgM, immunoglobulin M; IgD, immunoglobulin D; +, positive; and −, negative.
Performed only on cases 1 to 5. In case no. 6, material was unavailable for detailed immunophenotyping.