Case series reporting 15 or more consecutive patients with splenectomy for ITP that contain data on platelet count response, predictors of response, or surgical death and complications
Publication date and accrual years . | Reference . | Country . | No. patients . | No. splx ITP patients . | Splx method . | Complete response (%) . | Evaluated predictors of response . | Evaluated deaths and complications . |
|---|---|---|---|---|---|---|---|---|
| 1966 | ||||||||
| 1952-1965 | Kwietniak19 | Poland | 119 | 35 | OS | — | No | Yes |
| 1967 | ||||||||
| 1949-1966 | Wilde et al20 | United States | 43 | 42 | OS | — | Yes | Yes |
| 1968 | ||||||||
| 1952-1964 | Nordoy and Neset21 | Norway | 179 | 43 | OS | 32/37 (86) | No | Yes |
| 1970 | ||||||||
| 1951-1966 | Orringer et al22 | United States | 23 | 23 | OS | 14/19 (74) | Yes | Yes |
| 1959-1967 | Horta et al23 | United States | 34 | 15 | OS | 10/15 (67) | No | Yes |
| 1950-1967 | Hodam24 | United States | 310 | 34 | OS | — | No | Yes |
| 1972 | ||||||||
| 1945-1970 | Thompson et al25 | United States | 66 | 36 | OS | 24/35 (69) | Yes | Yes |
| 1973 | ||||||||
| 1956-1971 | JiJi et al26 | United States | 92 | 51 | OS | 34/51 (67) | No | Yes |
| 1974 | ||||||||
| 1944-1970 | Ogawa et al27 | Japan | 53 | 33 | OS | — | No | Yes |
| 1975 | ||||||||
| 1962-1970 | Cowick and Leon28 | United States | 693 | 21 | OS | — | No | Yes |
| 1967-1974 | Brennan et al29 | United States | 29 | 29 | OS | — | Yes | Yes |
| — | MacPherson and Richmond30 | United Kingdom | 72 | 72 | OS | 54/71 (76) | Yes | Yes |
| 1977 | ||||||||
| — | Ries31 | United States | 34 | 28 | OS | 20/28 (71) | Yes | Yes |
| 1978 | ||||||||
| — | Burger et al32 | Hungary | 86 | 40 | OS | 26/40 (65) | Yes | Yes |
| 1966-1973 | Ikkala et al33 | Finland | 41 | 24 | OS | 13/24 (54) | Yes | Yes |
| 1979 | ||||||||
| 1967-1979 | Laws et al34 | United States | 130 | 26 | OS | — | No | Yes |
| 1980 | ||||||||
| 1971-1979 | DiFino et al35 | United States | 62 | 37 | OS | 18/37 (49) | Yes | Yes |
| 1966-1978 | Butoianu36 | Romania | 188 | 110 | OS | — | No | Yes |
| 1959-1969 | Picozzi et al37 | United States | 38 | 36 | OS | 21/36 (58) | No | Yes |
| 1947-1978 | Schwartz et al38 | United States | 478 | 120 | OS | 101/115 (88) | No | Yes |
| 1981 | ||||||||
| 1965-1979 | Mintz et al39 | United States | 481 | 71 | OS | 33/45 (73) | No | No |
| 1964-1977 | Pawelski et al40 | Poland | 177 | 177 | OS | 80/118 (68) | No | Yes |
| 1974-1980 | Rubins and Woll41 | United States | 28 | 18 | OS | 12/17 (71) | No | Yes |
| 1968-1977 | Ly and Albrechtsen42 | Norway | 221 | 80 | OS | — | No | Yes |
| 1982 | ||||||||
| 1953-1977 | Gruenberg et al43 | United States | 98 | 98 | OS | 79/98 (81) | Yes | Yes |
| 1983 | ||||||||
| — | Kernoff and Malan44 | South Africa | 67 | 49 | OS | — | Yes | No |
| — | Kayser et al45 | Germany | 16 | 16 | OS | 9/15 (60) | Yes | Yes |
| 1984 | ||||||||
| 1973-1983 | Rocco and Stein46 | United States | 42 | 42 | OS | 23/40 (58) | Yes | Yes |
| — | den Ottolander et al47 | Netherlands | 168 | 75 | OS | 21/44 (48) | Yes | Yes |
| 1967-1980 | Salky et al48 | United States | 69 | 69 | OS | 56/69 (81) | No | Yes |
| — | Pizzuto and Ambriz49 | South America | 934 | 398 | OS | 259/398 (65) | Yes | Yes |
| 1956-1981 | Musser et al50 | United States | 306 | 65 | OS | 50/64 (78) | No | Yes |
| 1985 | ||||||||
| 1979-1984 | Schwartz51 | United States | 129 | 29 | OS | — | No | Yes |
| 1986 | ||||||||
| — | Yasunaga52 | Japan | 1669 | 399 | OS | — | Yes | No |
| 1975-1984 | Kochupillai et al53 | India | 90 | 27 | OS | 20/27 (74) | Yes | Yes |
| 1974-1983 | Malmaeus et al54 | Sweden | 167 | 52 | OS | — | No | Yes |
| 1971-1981 | Jacobs et al55 | South Africa | 148 | 102 | OS | 64/98 (65) | Yes | Yes |
| 1987 | ||||||||
| 1975-1985 | Akwari et al56 | United States | 565 | 100 | OS | 58/100 (58) | Yes | Yes |
| 1975-1985 | Lee et al57 | Taiwan | 113 | 32 | OS | 20/32 (63) | No | Yes |
| 1969-1983 | Dawson et al58 | United Kingdom | 185 | 34 | OS | — | No | Yes |
| 1983-1986 | Lang et al59 | France | 26 | 26 | OS | 19/26 (73) | No | Yes |
| — | Russo et al60 | Italy | 119 | 119 | OS | 78/119 (66) | Yes | Yes |
| 1967-1987 | Coon61 | United States | 216 | 216 | OS | 156/215 (73) | Yes | Yes |
| 1988 | ||||||||
| 1963-1982 | Wilhelm et al62 | United States | 400 | 72 | OS | — | No | Yes |
| 1979-1986 | Grant et al63 | United Kingdom | 106 | 30 | OS | 21/25 (84) | No | Yes |
| 1962-1985 | Wanachiwanawin et al64 | Thailand | 698 | 146 | OS | — | No | Yes |
| 1954-1983 | Guthrie et al65 | United States | 40 | 25 | OS | — | No | Yes |
| 1989 | ||||||||
| 1981-1988 | Siegel et al66 | United States | 59 | 19 | OS | 13/19 (68) | Yes | Yes |
| 1973-1986 | Fenaux et al67 | France | 181 | 181 | OS | 136/181 (75) | Yes | Yes |
| 1979-1987 | Shaw and Clark68 | New Zealand | 148 | 48 | OS | — | Yes | Yes |
| 1990 | ||||||||
| — | Julia et al69 | Spain | 138 | 138 | OS | 91/138 (66) | Yes | Yes |
| 1974-1986 | Johansson et al70 | Sweden | 200 | 20 | OS | — | No | Yes |
| 1979-1987 | Centurioni et al71 | Italy | 137 | 16 | OS | 11/16 (69) | No | No |
| 1983-1985 | Nieminen72 | Finland | 109 | 38 | OS | 27/38 (71) | Yes | Yes |
| 1991 | ||||||||
| 1985-1990 | Najean et al73 | France | 222 | 103 | OS | 64/89 (72) | Yes | Yes |
| 1970-1989 | Hoefer et al74 | United States | 59 | 17 | OS | — | No | Yes |
| 1992 | ||||||||
| 1974-1989 | MacRae et al75 | Canada | 142 | 69 | OS | — | No | Yes |
| 1981-1991 | Ketley et al76 | United Kingdom | 72 | 24 | OS | — | No | Yes |
| 1984-1990 | Chirletti et al77 | Italy | 70 | 70 | OS | 63/70 (90) | Yes | No |
| — | Dan et al78 | Japan | 247 | 72 | OS | 17/60 (28) | No | Yes |
| 1993 | ||||||||
| 1979-1990 | Naouri et al79 | France | 72 | 72 | OS | 51/71 (72) | Yes | Yes |
| 1984-1990 | Lamy et al80 | France | 111 | 51 | OS | 34/51 (67) | Yes | Yes |
| 1962-1987 | Wanachiwanawin et al81 | Thailand | 416 | 142 | OS | 62/126 (49) | Yes | No |
| 1970-1989 | Schiavotto and Rodeghiero82 | Italy | 490 | 178 | OS | 93/133 (70) | Yes | No |
| 1994 | ||||||||
| 1977-1987 | Ben-Yehuda et al83 | Israel | 712 | 173 | OS | 105/146 (72) | No | Yes |
| 1995 | ||||||||
| 1992-1994 | Emmermann et al84 | Germany | 27 | 19 | LS | — | No | Yes |
| 1980-1993 | Linares et al85 | Spain | 118 | 32 | OS | — | No | Yes |
| 1978-1988 | Stasi et al86 | Italy | 208 | 63 | OS | 23/63 (37) | Yes | Yes |
| 1978-1992 | Aksnes et al87 | Norway | 135 | 45 | OS | — | No | Yes |
| 1992-1994 | Gigot et al88 | Belgium | 50 | 31 | LS | 22/29 (76) | No | Yes |
| 1996 | ||||||||
| 1968-1993 | Hashizume et al89 | Japan | 41 | 41 | OS | 26/41 (63) | No | Yes |
| 1990-1996 | Brunt et al90 | United States | 26 | 17 | LS | 13/17 (76) | No | Yes |
| 1992-1995 | Flowers et al91 | United States | 43 | 22 | LS | 18/21 (86) | No | Yes |
| 1986-1992 | Jameson et al92 | United Kingdom | 64 | 28 | OS | 21/28 (75) | No | Yes |
| 1976-1996 | Shiino et al93 | Japan | 26 | 26 | OS | 15/26 (58) | Yes | Yes |
| 1984-1991 | Winde et al94 | Germany | 72 | 72 | OS | 52/70 (74) | Yes | Yes |
| 1993-1995 | Kitano et al95 | Japan | 24 | 20 | LS | — | No | Yes |
| 1993-1996 | Zamir et al96 | Israel | 17 | 15 | LS | 15/15 (100) | No | Yes |
| 1997 | ||||||||
| 1985-1995 | Watson et al97 | Australia | 47 | 47 | OS | 39/47 (83) | No | Yes |
| — | Schneider et al98 | Germany | 158 | 49 | — | — | Yes | No |
| 1990-1994 | Bohner et al99 | Germany | 56 | 24 | OS | — | No | Yes |
| 1992-1996 | Glasgow et al100 | United States | 28 | 16 | OS | — | No | Yes |
| 1992-1996 | Glasgow et al100 | United States | 52 | 23 | LS | — | No | Yes |
| 1980-1994 | Mittelman et al101 | Israel | 69 | 18 | OS | 14/18 (78) | No | Yes |
| 1991-1996 | Friedman et al102 | United States | 74 | 19 | OS | — | No | Yes |
| 1991-1996 | Friedman et al102 | United States | 63 | 30 | LS | — | No | Yes |
| 1998 | ||||||||
| 1990-1997 | Lozano-Salazar et al103 | Mexico | 27 | 27 | OS | 15/25 (60) | No | Yes |
| 1990-1997 | Lozano-Salazar et al103 | Mexico | 22 | 22 | LS | 12/21 (57) | No | Yes |
| 1988-1997 | Lord et al104 | Australia | 34 | 20 | OS | — | No | Yes |
| 1993-1997 | Yuan et al105 | Taiwan | 22 | 17 | OS | — | No | Yes |
| 1993-1997 | Yuan et al105 | Taiwan | 30 | 26 | LS | — | No | Yes |
| 1999 | ||||||||
| 1992-1997 | Harold et al106 | United States | 27 | 27 | LS | 19/26 (73) | Yes | Yes |
| 1983-1992 | Shimomatsuya and Horiuchi107 | Japan | 20 | 20 | OS | 6/16 (38) | No | Yes |
| 1994-1997 | Brody et al108 | United States | 27 | 27 | LS | 24/25 (96) | No | Yes |
| — | Louwes et al109 | Netherlands | 141 | 47 | — | 30/47 (64) | Yes | No |
| 1979-1999 | Mazzucconi et al110 | Italy | 94 | 94 | — | 53/81 (65) | Yes | No |
| 1994-1999 | Chung et al111 | Korea | 40 | 40 | LS | 28/40 (70) | Yes | Yes |
| — | Ruivard et al112 | France | 75 | 75 | — | — | Yes | No |
| 1992-1997 | Stanton113 | United States | 30 | 30 | LS | — | No | Yes |
| 1993-1998 | Donini et al114 | Italy | 44 | 24 | LS | — | No | Yes |
| 1992-1997 | Tanoue et al115 | Japan | 76 | 35 | LS | 21/35 (60) | No | Yes |
| 2000 | ||||||||
| 1982-1998 | Vecchio et al116 | Italy | 26 | 26 | OS | 21/26 (81) | Yes | No |
| 1978-1998 | Radaelli et al117 | Italy | 65 | 65 | — | 44/65 (68) | Yes | No |
| 1992-1999 | Bagdasarian et al118 | United States | 33 | 22 | LS | 14/22 (64) | No | Yes |
| 1982-1995 | Wani and Parray119 | India | 41 | 41 | OS | — | No | Yes |
| 1993-2000 | Park et al120 | United States, Canada | 203 | 129 | LS | — | No | Yes |
| 1994-1999 | Gibson et al121 | United States | 27 | 27 | OS,LS | 24/27 (89) | No | No |
| 1993-1999 | Trias et al122 | Spain | 111 | 48 | LS | 37/46 (80) | No | Yes |
| 2001 | ||||||||
| 1974-1994 | Portielje et al8 | Netherlands | 152 | 78 | OS | 51/60 (85) | No | Yes |
| 1960-1999 | Leung et al123 | Hong Kong | 220 | 37 | OS | — | Yes | No |
| 1992-1997 | Katkhouda et al124 | United States, France | 67 | 67 | LS | 52/67 (78) | Yes | Yes |
| — | Fabris et al5 | Italy | 61 | 61 | — | 31/54 (57) | Yes | No |
| 1987-1994 | Bussel et al125 | United States, Canada | 61 | 24 | OS | — | Yes | No |
| 1987-1998 | Choi et al126 | Korea | 107 | 79 | OS,LS | — | Yes | No |
| 2002 | ||||||||
| 1984-2000 | Pamuk et al127 | Turkey | 321 | 76 | — | 33/57 (58) | No | No |
| 1995-1998 | Chan et al128 | Australia | 31 | 20 | LS | — | No | Yes |
| 1991-2000 | Gadenstatter et al129 | Austria | 92 | 38 | OS | 33/38 (87) | No | Yes |
| — | Szold et al130 | Israel | 104 | 104 | LS | 82/102 (80) | No | Yes |
| 1985-1998 | Kumar et al131 | United States | 140 | 140 | OS,LS | 78/106 (74) | Yes | No |
| 1997-2001 | Torelli et al132 | Italy | 43 | 23 | LS | 15/23 (65) | No | Yes |
| 1993-1998 | Bresler et al133 | France | 27 | 27 | LS | 18/27 (67) | No | Yes |
| — | Rossi et al134 | Italy | 25 | 25 | — | 14/25 (56) | Yes | No |
| 1991-1998 | Delaitre et al135 | France | 209 | 195 | LS | — | No | Yes |
| 2003 | ||||||||
| 1993-1999 | Neylon et al9 | United Kingdom | 245 | 30 | — | 21/28 (75) | No | No |
| 1983-1996 | Srinivasan et al136 | India | 364 | 71 | — | 30/59 (51) | Yes | No |
| 1990-2001 | Zoghlami-Rintelen et al137 | Austria | 56 | 48 | OS,LS | 31/48 (65) | Yes | Yes |
| 1985-1994 | Bourgeois et al138 | France | 183 | 183 | OS | 159/183 (87) | Yes | Yes |
| 1992-2000 | Pace et al139 | Canada | 52 | 52 | LS | — | No | Yes |
| 1988-1993 | Schwartz et al6 | Israel, United States | 56 | 56 | OS | 32/56 (57) | Yes | Yes |
| 1995-2000 | Cordera et al140 | United States | 44 | 44 | OS | — | No | Yes |
| 1995-2000 | Cordera et al140 | United States | 42 | 42 | LS | — | No | Yes |
| 1997-2000 | George et al141 | United States | 70 | 28 | — | 15/28 (54) | No | No |
| 1985-1994 | Andres et al142 | France | 139 | 55 | OS,LS | 33/55 (60) | Yes | No |
| 1996-2002 | Knauer et al143 | United States | 101 | 48 | LS | — | No | Yes |
| 2004 | ||||||||
| 1995-2001 | Duperier et al144 | United States | 67 | 67 | LS | 43/67 (64) | Yes | Yes |
Publication date and accrual years . | Reference . | Country . | No. patients . | No. splx ITP patients . | Splx method . | Complete response (%) . | Evaluated predictors of response . | Evaluated deaths and complications . |
|---|---|---|---|---|---|---|---|---|
| 1966 | ||||||||
| 1952-1965 | Kwietniak19 | Poland | 119 | 35 | OS | — | No | Yes |
| 1967 | ||||||||
| 1949-1966 | Wilde et al20 | United States | 43 | 42 | OS | — | Yes | Yes |
| 1968 | ||||||||
| 1952-1964 | Nordoy and Neset21 | Norway | 179 | 43 | OS | 32/37 (86) | No | Yes |
| 1970 | ||||||||
| 1951-1966 | Orringer et al22 | United States | 23 | 23 | OS | 14/19 (74) | Yes | Yes |
| 1959-1967 | Horta et al23 | United States | 34 | 15 | OS | 10/15 (67) | No | Yes |
| 1950-1967 | Hodam24 | United States | 310 | 34 | OS | — | No | Yes |
| 1972 | ||||||||
| 1945-1970 | Thompson et al25 | United States | 66 | 36 | OS | 24/35 (69) | Yes | Yes |
| 1973 | ||||||||
| 1956-1971 | JiJi et al26 | United States | 92 | 51 | OS | 34/51 (67) | No | Yes |
| 1974 | ||||||||
| 1944-1970 | Ogawa et al27 | Japan | 53 | 33 | OS | — | No | Yes |
| 1975 | ||||||||
| 1962-1970 | Cowick and Leon28 | United States | 693 | 21 | OS | — | No | Yes |
| 1967-1974 | Brennan et al29 | United States | 29 | 29 | OS | — | Yes | Yes |
| — | MacPherson and Richmond30 | United Kingdom | 72 | 72 | OS | 54/71 (76) | Yes | Yes |
| 1977 | ||||||||
| — | Ries31 | United States | 34 | 28 | OS | 20/28 (71) | Yes | Yes |
| 1978 | ||||||||
| — | Burger et al32 | Hungary | 86 | 40 | OS | 26/40 (65) | Yes | Yes |
| 1966-1973 | Ikkala et al33 | Finland | 41 | 24 | OS | 13/24 (54) | Yes | Yes |
| 1979 | ||||||||
| 1967-1979 | Laws et al34 | United States | 130 | 26 | OS | — | No | Yes |
| 1980 | ||||||||
| 1971-1979 | DiFino et al35 | United States | 62 | 37 | OS | 18/37 (49) | Yes | Yes |
| 1966-1978 | Butoianu36 | Romania | 188 | 110 | OS | — | No | Yes |
| 1959-1969 | Picozzi et al37 | United States | 38 | 36 | OS | 21/36 (58) | No | Yes |
| 1947-1978 | Schwartz et al38 | United States | 478 | 120 | OS | 101/115 (88) | No | Yes |
| 1981 | ||||||||
| 1965-1979 | Mintz et al39 | United States | 481 | 71 | OS | 33/45 (73) | No | No |
| 1964-1977 | Pawelski et al40 | Poland | 177 | 177 | OS | 80/118 (68) | No | Yes |
| 1974-1980 | Rubins and Woll41 | United States | 28 | 18 | OS | 12/17 (71) | No | Yes |
| 1968-1977 | Ly and Albrechtsen42 | Norway | 221 | 80 | OS | — | No | Yes |
| 1982 | ||||||||
| 1953-1977 | Gruenberg et al43 | United States | 98 | 98 | OS | 79/98 (81) | Yes | Yes |
| 1983 | ||||||||
| — | Kernoff and Malan44 | South Africa | 67 | 49 | OS | — | Yes | No |
| — | Kayser et al45 | Germany | 16 | 16 | OS | 9/15 (60) | Yes | Yes |
| 1984 | ||||||||
| 1973-1983 | Rocco and Stein46 | United States | 42 | 42 | OS | 23/40 (58) | Yes | Yes |
| — | den Ottolander et al47 | Netherlands | 168 | 75 | OS | 21/44 (48) | Yes | Yes |
| 1967-1980 | Salky et al48 | United States | 69 | 69 | OS | 56/69 (81) | No | Yes |
| — | Pizzuto and Ambriz49 | South America | 934 | 398 | OS | 259/398 (65) | Yes | Yes |
| 1956-1981 | Musser et al50 | United States | 306 | 65 | OS | 50/64 (78) | No | Yes |
| 1985 | ||||||||
| 1979-1984 | Schwartz51 | United States | 129 | 29 | OS | — | No | Yes |
| 1986 | ||||||||
| — | Yasunaga52 | Japan | 1669 | 399 | OS | — | Yes | No |
| 1975-1984 | Kochupillai et al53 | India | 90 | 27 | OS | 20/27 (74) | Yes | Yes |
| 1974-1983 | Malmaeus et al54 | Sweden | 167 | 52 | OS | — | No | Yes |
| 1971-1981 | Jacobs et al55 | South Africa | 148 | 102 | OS | 64/98 (65) | Yes | Yes |
| 1987 | ||||||||
| 1975-1985 | Akwari et al56 | United States | 565 | 100 | OS | 58/100 (58) | Yes | Yes |
| 1975-1985 | Lee et al57 | Taiwan | 113 | 32 | OS | 20/32 (63) | No | Yes |
| 1969-1983 | Dawson et al58 | United Kingdom | 185 | 34 | OS | — | No | Yes |
| 1983-1986 | Lang et al59 | France | 26 | 26 | OS | 19/26 (73) | No | Yes |
| — | Russo et al60 | Italy | 119 | 119 | OS | 78/119 (66) | Yes | Yes |
| 1967-1987 | Coon61 | United States | 216 | 216 | OS | 156/215 (73) | Yes | Yes |
| 1988 | ||||||||
| 1963-1982 | Wilhelm et al62 | United States | 400 | 72 | OS | — | No | Yes |
| 1979-1986 | Grant et al63 | United Kingdom | 106 | 30 | OS | 21/25 (84) | No | Yes |
| 1962-1985 | Wanachiwanawin et al64 | Thailand | 698 | 146 | OS | — | No | Yes |
| 1954-1983 | Guthrie et al65 | United States | 40 | 25 | OS | — | No | Yes |
| 1989 | ||||||||
| 1981-1988 | Siegel et al66 | United States | 59 | 19 | OS | 13/19 (68) | Yes | Yes |
| 1973-1986 | Fenaux et al67 | France | 181 | 181 | OS | 136/181 (75) | Yes | Yes |
| 1979-1987 | Shaw and Clark68 | New Zealand | 148 | 48 | OS | — | Yes | Yes |
| 1990 | ||||||||
| — | Julia et al69 | Spain | 138 | 138 | OS | 91/138 (66) | Yes | Yes |
| 1974-1986 | Johansson et al70 | Sweden | 200 | 20 | OS | — | No | Yes |
| 1979-1987 | Centurioni et al71 | Italy | 137 | 16 | OS | 11/16 (69) | No | No |
| 1983-1985 | Nieminen72 | Finland | 109 | 38 | OS | 27/38 (71) | Yes | Yes |
| 1991 | ||||||||
| 1985-1990 | Najean et al73 | France | 222 | 103 | OS | 64/89 (72) | Yes | Yes |
| 1970-1989 | Hoefer et al74 | United States | 59 | 17 | OS | — | No | Yes |
| 1992 | ||||||||
| 1974-1989 | MacRae et al75 | Canada | 142 | 69 | OS | — | No | Yes |
| 1981-1991 | Ketley et al76 | United Kingdom | 72 | 24 | OS | — | No | Yes |
| 1984-1990 | Chirletti et al77 | Italy | 70 | 70 | OS | 63/70 (90) | Yes | No |
| — | Dan et al78 | Japan | 247 | 72 | OS | 17/60 (28) | No | Yes |
| 1993 | ||||||||
| 1979-1990 | Naouri et al79 | France | 72 | 72 | OS | 51/71 (72) | Yes | Yes |
| 1984-1990 | Lamy et al80 | France | 111 | 51 | OS | 34/51 (67) | Yes | Yes |
| 1962-1987 | Wanachiwanawin et al81 | Thailand | 416 | 142 | OS | 62/126 (49) | Yes | No |
| 1970-1989 | Schiavotto and Rodeghiero82 | Italy | 490 | 178 | OS | 93/133 (70) | Yes | No |
| 1994 | ||||||||
| 1977-1987 | Ben-Yehuda et al83 | Israel | 712 | 173 | OS | 105/146 (72) | No | Yes |
| 1995 | ||||||||
| 1992-1994 | Emmermann et al84 | Germany | 27 | 19 | LS | — | No | Yes |
| 1980-1993 | Linares et al85 | Spain | 118 | 32 | OS | — | No | Yes |
| 1978-1988 | Stasi et al86 | Italy | 208 | 63 | OS | 23/63 (37) | Yes | Yes |
| 1978-1992 | Aksnes et al87 | Norway | 135 | 45 | OS | — | No | Yes |
| 1992-1994 | Gigot et al88 | Belgium | 50 | 31 | LS | 22/29 (76) | No | Yes |
| 1996 | ||||||||
| 1968-1993 | Hashizume et al89 | Japan | 41 | 41 | OS | 26/41 (63) | No | Yes |
| 1990-1996 | Brunt et al90 | United States | 26 | 17 | LS | 13/17 (76) | No | Yes |
| 1992-1995 | Flowers et al91 | United States | 43 | 22 | LS | 18/21 (86) | No | Yes |
| 1986-1992 | Jameson et al92 | United Kingdom | 64 | 28 | OS | 21/28 (75) | No | Yes |
| 1976-1996 | Shiino et al93 | Japan | 26 | 26 | OS | 15/26 (58) | Yes | Yes |
| 1984-1991 | Winde et al94 | Germany | 72 | 72 | OS | 52/70 (74) | Yes | Yes |
| 1993-1995 | Kitano et al95 | Japan | 24 | 20 | LS | — | No | Yes |
| 1993-1996 | Zamir et al96 | Israel | 17 | 15 | LS | 15/15 (100) | No | Yes |
| 1997 | ||||||||
| 1985-1995 | Watson et al97 | Australia | 47 | 47 | OS | 39/47 (83) | No | Yes |
| — | Schneider et al98 | Germany | 158 | 49 | — | — | Yes | No |
| 1990-1994 | Bohner et al99 | Germany | 56 | 24 | OS | — | No | Yes |
| 1992-1996 | Glasgow et al100 | United States | 28 | 16 | OS | — | No | Yes |
| 1992-1996 | Glasgow et al100 | United States | 52 | 23 | LS | — | No | Yes |
| 1980-1994 | Mittelman et al101 | Israel | 69 | 18 | OS | 14/18 (78) | No | Yes |
| 1991-1996 | Friedman et al102 | United States | 74 | 19 | OS | — | No | Yes |
| 1991-1996 | Friedman et al102 | United States | 63 | 30 | LS | — | No | Yes |
| 1998 | ||||||||
| 1990-1997 | Lozano-Salazar et al103 | Mexico | 27 | 27 | OS | 15/25 (60) | No | Yes |
| 1990-1997 | Lozano-Salazar et al103 | Mexico | 22 | 22 | LS | 12/21 (57) | No | Yes |
| 1988-1997 | Lord et al104 | Australia | 34 | 20 | OS | — | No | Yes |
| 1993-1997 | Yuan et al105 | Taiwan | 22 | 17 | OS | — | No | Yes |
| 1993-1997 | Yuan et al105 | Taiwan | 30 | 26 | LS | — | No | Yes |
| 1999 | ||||||||
| 1992-1997 | Harold et al106 | United States | 27 | 27 | LS | 19/26 (73) | Yes | Yes |
| 1983-1992 | Shimomatsuya and Horiuchi107 | Japan | 20 | 20 | OS | 6/16 (38) | No | Yes |
| 1994-1997 | Brody et al108 | United States | 27 | 27 | LS | 24/25 (96) | No | Yes |
| — | Louwes et al109 | Netherlands | 141 | 47 | — | 30/47 (64) | Yes | No |
| 1979-1999 | Mazzucconi et al110 | Italy | 94 | 94 | — | 53/81 (65) | Yes | No |
| 1994-1999 | Chung et al111 | Korea | 40 | 40 | LS | 28/40 (70) | Yes | Yes |
| — | Ruivard et al112 | France | 75 | 75 | — | — | Yes | No |
| 1992-1997 | Stanton113 | United States | 30 | 30 | LS | — | No | Yes |
| 1993-1998 | Donini et al114 | Italy | 44 | 24 | LS | — | No | Yes |
| 1992-1997 | Tanoue et al115 | Japan | 76 | 35 | LS | 21/35 (60) | No | Yes |
| 2000 | ||||||||
| 1982-1998 | Vecchio et al116 | Italy | 26 | 26 | OS | 21/26 (81) | Yes | No |
| 1978-1998 | Radaelli et al117 | Italy | 65 | 65 | — | 44/65 (68) | Yes | No |
| 1992-1999 | Bagdasarian et al118 | United States | 33 | 22 | LS | 14/22 (64) | No | Yes |
| 1982-1995 | Wani and Parray119 | India | 41 | 41 | OS | — | No | Yes |
| 1993-2000 | Park et al120 | United States, Canada | 203 | 129 | LS | — | No | Yes |
| 1994-1999 | Gibson et al121 | United States | 27 | 27 | OS,LS | 24/27 (89) | No | No |
| 1993-1999 | Trias et al122 | Spain | 111 | 48 | LS | 37/46 (80) | No | Yes |
| 2001 | ||||||||
| 1974-1994 | Portielje et al8 | Netherlands | 152 | 78 | OS | 51/60 (85) | No | Yes |
| 1960-1999 | Leung et al123 | Hong Kong | 220 | 37 | OS | — | Yes | No |
| 1992-1997 | Katkhouda et al124 | United States, France | 67 | 67 | LS | 52/67 (78) | Yes | Yes |
| — | Fabris et al5 | Italy | 61 | 61 | — | 31/54 (57) | Yes | No |
| 1987-1994 | Bussel et al125 | United States, Canada | 61 | 24 | OS | — | Yes | No |
| 1987-1998 | Choi et al126 | Korea | 107 | 79 | OS,LS | — | Yes | No |
| 2002 | ||||||||
| 1984-2000 | Pamuk et al127 | Turkey | 321 | 76 | — | 33/57 (58) | No | No |
| 1995-1998 | Chan et al128 | Australia | 31 | 20 | LS | — | No | Yes |
| 1991-2000 | Gadenstatter et al129 | Austria | 92 | 38 | OS | 33/38 (87) | No | Yes |
| — | Szold et al130 | Israel | 104 | 104 | LS | 82/102 (80) | No | Yes |
| 1985-1998 | Kumar et al131 | United States | 140 | 140 | OS,LS | 78/106 (74) | Yes | No |
| 1997-2001 | Torelli et al132 | Italy | 43 | 23 | LS | 15/23 (65) | No | Yes |
| 1993-1998 | Bresler et al133 | France | 27 | 27 | LS | 18/27 (67) | No | Yes |
| — | Rossi et al134 | Italy | 25 | 25 | — | 14/25 (56) | Yes | No |
| 1991-1998 | Delaitre et al135 | France | 209 | 195 | LS | — | No | Yes |
| 2003 | ||||||||
| 1993-1999 | Neylon et al9 | United Kingdom | 245 | 30 | — | 21/28 (75) | No | No |
| 1983-1996 | Srinivasan et al136 | India | 364 | 71 | — | 30/59 (51) | Yes | No |
| 1990-2001 | Zoghlami-Rintelen et al137 | Austria | 56 | 48 | OS,LS | 31/48 (65) | Yes | Yes |
| 1985-1994 | Bourgeois et al138 | France | 183 | 183 | OS | 159/183 (87) | Yes | Yes |
| 1992-2000 | Pace et al139 | Canada | 52 | 52 | LS | — | No | Yes |
| 1988-1993 | Schwartz et al6 | Israel, United States | 56 | 56 | OS | 32/56 (57) | Yes | Yes |
| 1995-2000 | Cordera et al140 | United States | 44 | 44 | OS | — | No | Yes |
| 1995-2000 | Cordera et al140 | United States | 42 | 42 | LS | — | No | Yes |
| 1997-2000 | George et al141 | United States | 70 | 28 | — | 15/28 (54) | No | No |
| 1985-1994 | Andres et al142 | France | 139 | 55 | OS,LS | 33/55 (60) | Yes | No |
| 1996-2002 | Knauer et al143 | United States | 101 | 48 | LS | — | No | Yes |
| 2004 | ||||||||
| 1995-2001 | Duperier et al144 | United States | 67 | 67 | LS | 43/67 (64) | Yes | Yes |
The 135 case series that were reviewed for this analysis are presented in order of their year of publication. Case series for which accrual data were not available are designated (—). The technique for splenectomy (splx) is designated as os, splenectomy by open laparotomy, or ls, laparoscopic splenectomy. For studies with patient accrual beginning after 1991, the year of the first report of laparoscopic splenectomy for ITP,18 that did not define the surgical technique, the surgical technique is not specified (—). For studies that accrued patients prior to 1991, splenectomy was assumed to be performed by open laparotomy if the surgical technique was not defined. Articles selected for review had evaluable data for 1 or more of the outcomes of interest: platelet count response, predictors of response, or death and complications caused by splenectomy. When articles could be evaluated for platelet count response, the number and percentage of patients achieving a complete remission is presented with the total number of evaluable patients. Case series that did not describe complete remission are designated (—). In some articles some patients who had splenectomy for ITP were not evaluated for platelet count response because they were not followed or because they were children.