Table 1. Estimated toxicity coefficients... | American Society of Hematology

Table 1.

Estimated toxicity coefficients

Coefficient	Stem cells/CFU-GM*	Mitotic precursors†	Postmitotic precursors‡
K_{CPH + DOX + VIN}; 60 or older	0.195 (0.185-0.198)	0.5 (> 0.15)	Set to 0.0
k_{CPH + DOX + VIN}; younger than 60 y	0.178 (0.170-0.185)	0.098 (0.06-0.1)	Set to 0.0
K_ETO; 60 y or older	0.0047 (0.004-0.008)	0.9496 (> 0.06)	0.0051 (0.0025-0.008)
k_ETO; younger than 60 y	0.003 (0.0-0.007)	0.187 (0.06-0.7)	0.0019 (0.001-0.0035)
K_PRO	0.0063	0.0237	0.0015
K_VIN	0.0385	0.0732	0.0
F_first-cycle; 60 y or older§	1.31	1.31	1.31
F_first-cycle; younger than 60 y§	1.27	1.27	1.27

Coefficient	Stem cells/CFU-GM*	Mitotic precursors†	Postmitotic precursors‡
K_{CPH + DOX + VIN}; 60 or older	0.195 (0.185-0.198)	0.5 (> 0.15)	Set to 0.0
k_{CPH + DOX + VIN}; younger than 60 y	0.178 (0.170-0.185)	0.098 (0.06-0.1)	Set to 0.0
K_ETO; 60 y or older	0.0047 (0.004-0.008)	0.9496 (> 0.06)	0.0051 (0.0025-0.008)
k_ETO; younger than 60 y	0.003 (0.0-0.007)	0.187 (0.06-0.7)	0.0019 (0.001-0.0035)
K_PRO	0.0063	0.0237	0.0015
K_VIN	0.0385	0.0732	0.0
F_first-cycle; 60 y or older§	1.31	1.31	1.31
F_first-cycle; younger than 60 y§	1.27	1.27	1.27

The values in the parentheses present the limits for the tolerance interval of parameter estimates. See “Results” for further explanation.

S/CG.

PGP.

MGP.

This parameter is assumed to be equal in all compartments.