Table 2. Common CDR3 amino acid motifs... | American Society of Hematology

Table 2.

Common CDR3 amino acid motifs found in 51p1-encoded heavy chains

					Associated light chain			Specific V_κ genes
CDR3 amino acid sequence motif	D gene	RF	J_H gene	Sample no.	Lambda (%*)	Kappa (%*)	A27 (%†)	O2 (%†)
DIVVVPAA(I/M)	D2-2	3	J_H6	20	4 (20)	16 (75)	0 (0)	10 (63)
YDFWSGY	D3-3	2	J_H3/4	6	0 (0)	6 (100)	1 (17)	ND
GGYDFWSGYY	D3-3	2	J_H6	15	10 (67)	5 (33)	1 (20)	0 (0)
TIFGVVI	D3-3	3	J_H4/6	10	2 (20)	8 (80)	1 (13)	ND
GGXYDY(I/V)WGSYRPNDAFDI	D3-16	2	J_H3	15	0 (0)	15 (100)	15 (100)	0 (0)

					Associated light chain			Specific V_κ genes
CDR3 amino acid sequence motif	D gene	RF	J_H gene	Sample no.	Lambda (%*)	Kappa (%*)	A27 (%†)	O2 (%†)
DIVVVPAA(I/M)	D2-2	3	J_H6	20	4 (20)	16 (75)	0 (0)	10 (63)
YDFWSGY	D3-3	2	J_H3/4	6	0 (0)	6 (100)	1 (17)	ND
GGYDFWSGYY	D3-3	2	J_H6	15	10 (67)	5 (33)	1 (20)	0 (0)
TIFGVVI	D3-3	3	J_H4/6	10	2 (20)	8 (80)	1 (13)	ND
GGXYDY(I/V)WGSYRPNDAFDI	D3-16	2	J_H3	15	0 (0)	15 (100)	15 (100)	0 (0)

Underlined letters (X) indicate the presence of that amino acid in more than 67% of the samples.

ND indicates not determined.

The percent of the V_H subgroup.

The percent of the V_κ subgroup.