In vitro drug resistance in 275 children with precursor B-ALL positive or negative for ETV6/RUNX1 gene fusion
. | ETV6/RUNX1+ . | ETV6/RUNX1- . | . |
|---|---|---|---|
| Drug . | Median (25th-75th) . | Median (25th-75th) . | P . |
| Doxorubicin | 32 (16-44) | 40 (23-56) | .003 |
| Etoposide | 35 (22-54) | 57 (35-80) | .001 |
| Amsacrine | 29 (17-45) | 37 (21-53) | .015 |
| Dexamethasone | 49 (31-66) | 60 (41-77) | .043 |
| Cytarabine | 63 (52-75) | 55 (39-74) | .016 |
| Prednisolone | 52 (32-73) | 54 (38-72) | .27 |
| Vincristine | 53 (41-67) | 57 (40-79) | .32 |
| 6-thioguanine | 42 (24-60) | 41 (24-58) | .90 |
| 4-HC | 20 (12-48) | 29 (13-42) | .56 |
. | ETV6/RUNX1+ . | ETV6/RUNX1- . | . |
|---|---|---|---|
| Drug . | Median (25th-75th) . | Median (25th-75th) . | P . |
| Doxorubicin | 32 (16-44) | 40 (23-56) | .003 |
| Etoposide | 35 (22-54) | 57 (35-80) | .001 |
| Amsacrine | 29 (17-45) | 37 (21-53) | .015 |
| Dexamethasone | 49 (31-66) | 60 (41-77) | .043 |
| Cytarabine | 63 (52-75) | 55 (39-74) | .016 |
| Prednisolone | 52 (32-73) | 54 (38-72) | .27 |
| Vincristine | 53 (41-67) | 57 (40-79) | .32 |
| 6-thioguanine | 42 (24-60) | 41 (24-58) | .90 |
| 4-HC | 20 (12-48) | 29 (13-42) | .56 |
The concentrations of the drugs used are denoted in Table 1.
All the values represent the percentage of surviving cells compared with control wells, presented as median or 25th to 75th percentile. P values were determined by the Mann-Whitney U test.