Partial list of genes expressed differentially in specimens from FLT3-MU patients with induction refractoriness or relapse versus CCR as shown inFigure 3
Gene category and name . | Functional class . |
|---|---|
| Lower expression in CCR | |
| RUNX3, runt related transcription factor 3 | Transcriptional regulation, cell proliferation |
| CYLD, cylindromatosis (turban tumor syndrome) | Tumor suppressor gene |
| PCTK2, PCTAIRE protein kinase 2 | ATP binding, protein serine/threonine kinase, transferase activity |
| RAB5A, member RAS oncogene family | Required for the fusion of plasma membranes and early endosomes |
| ETEA, expressed in T cells and eosinophils in atopic dermatitis | Potentiates FAS induced apoptosis |
| SNRK, SNF-1 related kinase | Essential for release from glucose repression, interacts with SNF4, SIP1, SIP2, and GAL83 |
| WTAP, Wilms tumor 1 associated protein | Plays a role in transcriptional and posttranscriptional regulation of genes |
| RYBP, RING1 and YY1 binding protein | Interacts with Polycomb transcriptional repressor complex and with the transcription factor YY1 |
| INSIG1, insulin induced gene 1 | May play a role in tissue growth and differentiation, G0/G1 transition |
| MAPK6, mitogen activated protein kinase 6 | Phosphorylates MAP2, may promote entry into cell cycle |
| RC3, rabconnectin 3 | Calmodulin binding protein |
| PHLDA1, pleckstrin homology-like domain, family A, member 1 | Binds phosphoinositides, involved in platelet cytoskeletal changes |
| PK1B, protein kinase (cAMP-dependent, catalytic) inhibitor beta | May act as a competitive inhibitor of cAMP-dependent protein kinase |
| Higher expression in CCR | |
| ATRX, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, Saccharomyces cerevisiae) | SWI/SNF chromatin remodeling protein; ATPase/helicase domain; mutations cause changes in pattern of methylation |
| PPP5C, protein phosphatase 5, catalytic subunit | Regulation of RNA biogenesis, or mitosis; dephosphorylates serine residues, and histone H1 |
Gene category and name . | Functional class . |
|---|---|
| Lower expression in CCR | |
| RUNX3, runt related transcription factor 3 | Transcriptional regulation, cell proliferation |
| CYLD, cylindromatosis (turban tumor syndrome) | Tumor suppressor gene |
| PCTK2, PCTAIRE protein kinase 2 | ATP binding, protein serine/threonine kinase, transferase activity |
| RAB5A, member RAS oncogene family | Required for the fusion of plasma membranes and early endosomes |
| ETEA, expressed in T cells and eosinophils in atopic dermatitis | Potentiates FAS induced apoptosis |
| SNRK, SNF-1 related kinase | Essential for release from glucose repression, interacts with SNF4, SIP1, SIP2, and GAL83 |
| WTAP, Wilms tumor 1 associated protein | Plays a role in transcriptional and posttranscriptional regulation of genes |
| RYBP, RING1 and YY1 binding protein | Interacts with Polycomb transcriptional repressor complex and with the transcription factor YY1 |
| INSIG1, insulin induced gene 1 | May play a role in tissue growth and differentiation, G0/G1 transition |
| MAPK6, mitogen activated protein kinase 6 | Phosphorylates MAP2, may promote entry into cell cycle |
| RC3, rabconnectin 3 | Calmodulin binding protein |
| PHLDA1, pleckstrin homology-like domain, family A, member 1 | Binds phosphoinositides, involved in platelet cytoskeletal changes |
| PK1B, protein kinase (cAMP-dependent, catalytic) inhibitor beta | May act as a competitive inhibitor of cAMP-dependent protein kinase |
| Higher expression in CCR | |
| ATRX, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, Saccharomyces cerevisiae) | SWI/SNF chromatin remodeling protein; ATPase/helicase domain; mutations cause changes in pattern of methylation |
| PPP5C, protein phosphatase 5, catalytic subunit | Regulation of RNA biogenesis, or mitosis; dephosphorylates serine residues, and histone H1 |
ATP indicates adenosine triphosphate; cAMP, cyclic adenosine monophosphate.