Patient characteristics
. | Clinical outcome, no. = 81 . | . | . | FLT3 status, no. = 72 . | . | . | All patients, POG-9421 . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics . | IR . | R . | CCR . | ITD . | ALM . | WT . | . | ||||
| No. | 23 | 30 | 28 | 24 | 12 | 36 | 622 | ||||
| Median age, y (range) | 12.8 (0.1-18.4) | 10.2 (0.4-19.3) | 8.3 (0.5-18.8) | 12.9 (2.5-18.4) | 10.2 (0.4-15.3) | 7.4 (0.1-19.3) | − | ||||
| Median WBC count (range) | 90.2 (8.5-483.0) | 77 (2.1-634.0) | 75.4 (1.5-492.0) | 98.0 (8.5-492.0) | 46.0 (2.1-483.0) | 65.1 (1.3-633.0) | − | ||||
| FAB | |||||||||||
| MO | 0 | 3 | 1 | 3 | 0 | 1 | 25 | ||||
| M1 | 8 | 7 | 9 | 7 | 3 | 11 | 102 | ||||
| M2 | 7 | 6 | 10 | 10 | 3 | 7 | 148 | ||||
| M4 | 6 | 7 | 2 | 3 | 3 | 7 | 91 | ||||
| M5 | 2 | 5 | 4 | 0 | 2 | 8 | 113 | ||||
| M6 | 0 | 1 | 0 | 0 | 0 | 1 | 8 | ||||
| M7 | 0 | 1 | 1 | 1 | 1 | 0 | 49 | ||||
| MX | 0 | 0 | 0 | 0 | 0 | 0 | 29 | ||||
| DS | 0 | 0 | 1 | 0 | 0 | 1 | 57 | ||||
| Cytogenetics | |||||||||||
| Normal | 7 | 6 | 9 | 7 | 5 | 10 | 156 | ||||
| t (8;21) | 1 | 0 | 1 | 0 | 0 | 2 | 59 | ||||
| inv (16) | 0 | 3 | 7 | 1 | 3 | 2 | 38 | ||||
| 11q2 3 | 1 | 6 | 6 | 2 | 1 | 9 | 85 | ||||
| Miscellaneous | 9 | 10 | 3 | 9 | 2 | 10 | 177 | ||||
| NA | 5 | 5 | 2 | 5 | 1 | 3 | 107 | ||||
| 3-y EFS, % (± SE) | 0 | 0 | 100 | 22 (± 9) | 23 (± 12) | 46 (± 8) | 42 (± 2) | ||||
. | Clinical outcome, no. = 81 . | . | . | FLT3 status, no. = 72 . | . | . | All patients, POG-9421 . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics . | IR . | R . | CCR . | ITD . | ALM . | WT . | . | ||||
| No. | 23 | 30 | 28 | 24 | 12 | 36 | 622 | ||||
| Median age, y (range) | 12.8 (0.1-18.4) | 10.2 (0.4-19.3) | 8.3 (0.5-18.8) | 12.9 (2.5-18.4) | 10.2 (0.4-15.3) | 7.4 (0.1-19.3) | − | ||||
| Median WBC count (range) | 90.2 (8.5-483.0) | 77 (2.1-634.0) | 75.4 (1.5-492.0) | 98.0 (8.5-492.0) | 46.0 (2.1-483.0) | 65.1 (1.3-633.0) | − | ||||
| FAB | |||||||||||
| MO | 0 | 3 | 1 | 3 | 0 | 1 | 25 | ||||
| M1 | 8 | 7 | 9 | 7 | 3 | 11 | 102 | ||||
| M2 | 7 | 6 | 10 | 10 | 3 | 7 | 148 | ||||
| M4 | 6 | 7 | 2 | 3 | 3 | 7 | 91 | ||||
| M5 | 2 | 5 | 4 | 0 | 2 | 8 | 113 | ||||
| M6 | 0 | 1 | 0 | 0 | 0 | 1 | 8 | ||||
| M7 | 0 | 1 | 1 | 1 | 1 | 0 | 49 | ||||
| MX | 0 | 0 | 0 | 0 | 0 | 0 | 29 | ||||
| DS | 0 | 0 | 1 | 0 | 0 | 1 | 57 | ||||
| Cytogenetics | |||||||||||
| Normal | 7 | 6 | 9 | 7 | 5 | 10 | 156 | ||||
| t (8;21) | 1 | 0 | 1 | 0 | 0 | 2 | 59 | ||||
| inv (16) | 0 | 3 | 7 | 1 | 3 | 2 | 38 | ||||
| 11q2 3 | 1 | 6 | 6 | 2 | 1 | 9 | 85 | ||||
| Miscellaneous | 9 | 10 | 3 | 9 | 2 | 10 | 177 | ||||
| NA | 5 | 5 | 2 | 5 | 1 | 3 | 107 | ||||
| 3-y EFS, % (± SE) | 0 | 0 | 100 | 22 (± 9) | 23 (± 12) | 46 (± 8) | 42 (± 2) | ||||
DS indicates Down syndrome; NA, not available; -, not applicable.