Clinical and biochemical outcome
. | Patient no. 1 . | . | Patient no. 2 . | . | Patient no. 3 . | . | Patient no. 4 . | . | Patient no. 5 . | . | Patient no. 6 . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | A . | B . | A . | B . | A . | B . | A . | B . | A . | B . | A . | B . | ||||||
| Scored by the patient | ||||||||||||||||||
| Itching | 3 | 0 | 2 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | ||||||
| Tightness of the skin | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 1 | 2 | 2 | 3 | 3 | ||||||
| Malaise | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 3 | 3 | ||||||
| Hair loss | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | ||||||
| Dysphagia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | ||||||
| Dyspnea | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | ||||||
| Oral mucositis | 0 | 0 | 2 | 0 | 3 | 2 | 3 | 2 | 0 | 0 | 1 | 0 | ||||||
| Scored by the clinician | ||||||||||||||||||
| Redness | 1 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | ||||||
| Sclerosis of the skin | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 1 | 2 | 2 | 3 | 3 | ||||||
| Hair loss | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | ||||||
| Oral mucositis | 0 | 0 | 2 | 0 | 3 | 2 | 3 | 2 | 0 | 0 | 1 | 0 | ||||||
| Liver function tests | ||||||||||||||||||
| Alkaline phosphatase level, U/L | 145 | 94 | 59 | 71 | 206 | 87 | 323 | 199 | 74 | 69 | 159 | 161 | ||||||
| γ-glutamyltransferase level, U/L | 191 | 60 | 150 | 170 | 234 | 60 | 864 | 578 | 54 | 67 | 405 | 193 | ||||||
| Alanine aminotransferase level, U/L | 68 | 14 | 53 | 60 | 94 | 25 | 119 | 77 | 30 | 37 | 77 | 36 | ||||||
| Autoantibodies | ||||||||||||||||||
| Antinuclear antibody | Neg | Neg | Neg | Neg | Neg | Neg | Pos | Neg | Neg | Neg | Pos | Neg | ||||||
| Antismooth muscle antibody | Pos | Pos | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Neg | ||||||
| Antimitochondrial antibody | Pos | Pos | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Pos | Neg | ||||||
. | Patient no. 1 . | . | Patient no. 2 . | . | Patient no. 3 . | . | Patient no. 4 . | . | Patient no. 5 . | . | Patient no. 6 . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | A . | B . | A . | B . | A . | B . | A . | B . | A . | B . | A . | B . | ||||||
| Scored by the patient | ||||||||||||||||||
| Itching | 3 | 0 | 2 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | ||||||
| Tightness of the skin | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 1 | 2 | 2 | 3 | 3 | ||||||
| Malaise | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 3 | 3 | ||||||
| Hair loss | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | ||||||
| Dysphagia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | ||||||
| Dyspnea | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | ||||||
| Oral mucositis | 0 | 0 | 2 | 0 | 3 | 2 | 3 | 2 | 0 | 0 | 1 | 0 | ||||||
| Scored by the clinician | ||||||||||||||||||
| Redness | 1 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | ||||||
| Sclerosis of the skin | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 1 | 2 | 2 | 3 | 3 | ||||||
| Hair loss | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | ||||||
| Oral mucositis | 0 | 0 | 2 | 0 | 3 | 2 | 3 | 2 | 0 | 0 | 1 | 0 | ||||||
| Liver function tests | ||||||||||||||||||
| Alkaline phosphatase level, U/L | 145 | 94 | 59 | 71 | 206 | 87 | 323 | 199 | 74 | 69 | 159 | 161 | ||||||
| γ-glutamyltransferase level, U/L | 191 | 60 | 150 | 170 | 234 | 60 | 864 | 578 | 54 | 67 | 405 | 193 | ||||||
| Alanine aminotransferase level, U/L | 68 | 14 | 53 | 60 | 94 | 25 | 119 | 77 | 30 | 37 | 77 | 36 | ||||||
| Autoantibodies | ||||||||||||||||||
| Antinuclear antibody | Neg | Neg | Neg | Neg | Neg | Neg | Pos | Neg | Neg | Neg | Pos | Neg | ||||||
| Antismooth muscle antibody | Pos | Pos | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Neg | ||||||
| Antimitochondrial antibody | Pos | Pos | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Neg | Pos | Neg | ||||||
Symptoms were scored as follows: 0, not present; 1 mild; 2, moderate; 3, severe.
A indicates before treatment; B, after treatment; neg, negative; pos, positive.