Association between day-14 donor chimerism levels and graft rejection
% Donor chimerism on day 14 . | No. of patients with rejection/no. patients at risk* (%) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | T cells . | NK cells . | Monocytes . | Granulocytes . | |||
| 0 to 25 | 4/9 (44) | 5/9 (56) | 5/18 (28) | 6/66 (9) | |||
| 26 to 50 | 4/23 (17) | 1/9 (11) | 0/21 | 2/15 (13) | |||
| 51 to 75 | 1/40 (2.5) | 1/19 (5) | 1/28 (4) | 0/4 (0) | |||
| 76 to 90 | 0/22 (0) | 0/35 (0) | 0/15 (0) | 0/6 (0) | |||
| 91 to 100 | 0/6 (0) | 0/14 (0) | 0/10 (0) | 0/5 (0) | |||
% Donor chimerism on day 14 . | No. of patients with rejection/no. patients at risk* (%) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | T cells . | NK cells . | Monocytes . | Granulocytes . | |||
| 0 to 25 | 4/9 (44) | 5/9 (56) | 5/18 (28) | 6/66 (9) | |||
| 26 to 50 | 4/23 (17) | 1/9 (11) | 0/21 | 2/15 (13) | |||
| 51 to 75 | 1/40 (2.5) | 1/19 (5) | 1/28 (4) | 0/4 (0) | |||
| 76 to 90 | 0/22 (0) | 0/35 (0) | 0/15 (0) | 0/6 (0) | |||
| 91 to 100 | 0/6 (0) | 0/14 (0) | 0/10 (0) | 0/5 (0) | |||
P values were obtained from trend test in a logistic regression model after adjusting for presence of unrelated donor: T cells, P = .003; NK cells, P = .004; monocytes, P = .02; and granulocytes, P = .22.
Day-14 T-cell, NK-cell, monocyte, and granulocyte chimerism data were available for 100, 86, 92, and 96 patients, respectively.