Chemoattractants implicated in the recruitment of monocytes to tumors
Chemoattractant and tumor . | Regulated by hypoxia in tumor cells . | Method of detection . | Positive correlation with TAM accumulation . | Reference no. . |
|---|---|---|---|---|
| CCL2 | ? | |||
| Breast | ELISA/IHC | Y | Ueno et al33 | |
| Ovarian | ISH/ELISA | Y | Negus et al17,34 | |
| Melanoma | IHC | ND | Graves et al35 | |
| Non-small lung | IHC | Y | Arenberg et al36 | |
| Glioblastoma | IHC/ISH | Y | Leung et al37 | |
| Meningioma | IHC/NB | ND | Sato et al38 | |
| Esophageal and squamous cell | IHC/RT-PCR | Y | Ohta et al39 | |
| CCL5 | ? | |||
| Breast | IHC/ELISA | ND | Luboshits et al40 , Niwa et al41 | |
| Melanoma | WB/ELISA | ND | Mrowietz et al42 | |
| Cervical | ELISA | ND | Niwa et al41 | |
| CSF-1 | No | |||
| Breast | IHC | Y | Tang et al43 , Lin et al44 | |
| Ovarian | IHC | ND | Kacinski et al45 | |
| Adenocarcinoma | IHC/ELISA | ND | Kacinski et al45 | |
| VEGF | Yes | |||
| Numerous | Numerous | Y | Lewis et al21 , *Ferrara and Davis-Smyth46 * | |
| EMAP II | Yes | |||
| Fibrosarcoma | ISH/RT-PCR | ND | Kao et al47 | |
| Melanoma | IHC | Y | Clarijs et al48 | |
| Endothelin: ET-1, ET-2 | Yes | |||
| Numerous | IHC | Y | Grant et al49 ,* | |
| Grimshaw et al50 * |
Chemoattractant and tumor . | Regulated by hypoxia in tumor cells . | Method of detection . | Positive correlation with TAM accumulation . | Reference no. . |
|---|---|---|---|---|
| CCL2 | ? | |||
| Breast | ELISA/IHC | Y | Ueno et al33 | |
| Ovarian | ISH/ELISA | Y | Negus et al17,34 | |
| Melanoma | IHC | ND | Graves et al35 | |
| Non-small lung | IHC | Y | Arenberg et al36 | |
| Glioblastoma | IHC/ISH | Y | Leung et al37 | |
| Meningioma | IHC/NB | ND | Sato et al38 | |
| Esophageal and squamous cell | IHC/RT-PCR | Y | Ohta et al39 | |
| CCL5 | ? | |||
| Breast | IHC/ELISA | ND | Luboshits et al40 , Niwa et al41 | |
| Melanoma | WB/ELISA | ND | Mrowietz et al42 | |
| Cervical | ELISA | ND | Niwa et al41 | |
| CSF-1 | No | |||
| Breast | IHC | Y | Tang et al43 , Lin et al44 | |
| Ovarian | IHC | ND | Kacinski et al45 | |
| Adenocarcinoma | IHC/ELISA | ND | Kacinski et al45 | |
| VEGF | Yes | |||
| Numerous | Numerous | Y | Lewis et al21 , *Ferrara and Davis-Smyth46 * | |
| EMAP II | Yes | |||
| Fibrosarcoma | ISH/RT-PCR | ND | Kao et al47 | |
| Melanoma | IHC | Y | Clarijs et al48 | |
| Endothelin: ET-1, ET-2 | Yes | |||
| Numerous | IHC | Y | Grant et al49 ,* | |
| Grimshaw et al50 * |
ELISA indicates enzyme-linked immunosorbent assay; IHC, immunohistochemistry, Y, yes; ISH, in situ hybridization; ND, not determined; NB, Northern blotting; WB, Western blotting; and RT-PCR, real-time polymerase chain reaction.
Reviews.