Interaction between TYMS 3R → 2R and 1494del6 polymorphisms in all NHL cases and controls
. | Controls, no. . | AII NHL cases, no. . | OR (95% CI) . | OR (95% CI)* . |
|---|---|---|---|---|
| At TYMS 6bp+6bp+ | ||||
| 3R3R | 77 | 26 | 1.0 (referent) | 1.0 |
| 3R2R | 151 | 86 | 1.7 (1.0-2.8) | 1.7 (1.0-2.8) |
| 2R2R | 102 | 52 | 1.5 (.87-2.6) | 1.5 (.87-2.6) |
| At TYMS 6bp+6bp− | ||||
| 3R3R | 90 | 52 | 1.0 (referent) | 1.7 (.97-3.0) |
| 3R2R | 168 | 79 | .81 (.53-1.3) | 1.4 (.83-2.3) |
| 2R2R | 46 | 11 | .41 (.20-.87) | .71 (.32-1.6) |
| At TYMS 6bp−6bp− | ||||
| 3R3R | 42 | 17 | 1.0 (referent) | 1.2 (.58-2.5) |
| 3R2R | 27 | 4 | .37 (.11-1.2) | .44 (.14-1.4) |
| 2R2R | 10 | 1 | .25 (.03-2.1) | .30 (.04-2.5) |
. | Controls, no. . | AII NHL cases, no. . | OR (95% CI) . | OR (95% CI)* . |
|---|---|---|---|---|
| At TYMS 6bp+6bp+ | ||||
| 3R3R | 77 | 26 | 1.0 (referent) | 1.0 |
| 3R2R | 151 | 86 | 1.7 (1.0-2.8) | 1.7 (1.0-2.8) |
| 2R2R | 102 | 52 | 1.5 (.87-2.6) | 1.5 (.87-2.6) |
| At TYMS 6bp+6bp− | ||||
| 3R3R | 90 | 52 | 1.0 (referent) | 1.7 (.97-3.0) |
| 3R2R | 168 | 79 | .81 (.53-1.3) | 1.4 (.83-2.3) |
| 2R2R | 46 | 11 | .41 (.20-.87) | .71 (.32-1.6) |
| At TYMS 6bp−6bp− | ||||
| 3R3R | 42 | 17 | 1.0 (referent) | 1.2 (.58-2.5) |
| 3R2R | 27 | 4 | .37 (.11-1.2) | .44 (.14-1.4) |
| 2R2R | 10 | 1 | .25 (.03-2.1) | .30 (.04-2.5) |
Likelihood ratio test for interaction: P = .01.
OR and 95% CI computed using 3R3R/6bp+6bp+ as referent.