Table 3.

TYMS, MTHFR, SHMT1, MTR, and RFC genotype frequencies, odds ratios (ORs), and 95% confidence intervals (Cls) in NHL cases and controls using wild types as the referent groups

Control, no. (%)
All NHL cases
DLCL
FL
Other
Genotype
No. (%)
OR
P
No. (%)
OR
P
No. (%)
OR
P
No. (%)
OR
P
TYMS 3R → 2R              
3R/3R   209 (29)   97 (29)   1.1 (.77-1.6)   .53   29 (27)   1.0 (.55-1.8)   .99   33 (27)   1.2 (.66-2.1)   .56   35 (33)   1.2 (.68-2.1)   .53  
3R/2R   346 (48)   170 (51)   1.2 (.85-1.7)   .31   55 (52)   1.1 (.67-1.9)   .62   67 (55)   1.5 (.86-2.5)   .16   48 (46)   1.0 (.58-1.7)   .99  
2R/2R   158 (22)   65 (20)   1.0   NA   22 (21)   1.0   NA   21 (17)   1.0   NA   22 (21)   1.0   NA  
3R/3R vs 3R/2R     .94 (.70-1.3)   .71    .87 (.54-1.4)   .58    .81 (.52-1.3)   .37    1.2 (.76-1.9)   .43  
SNA   18   5     2     1     2    
Total   731   337     108     122     107    
TYMS 1494del6              
6bp+6bp+  335 (46)   166 (50)   1.0   NA   58 (54)   1.0   NA   62 (51)   1.0   NA   47 (45)   1.0   NA  
6bp+6bp−  310 (43)   144 (43)   .94 (.71-1.2)   .64   45 (42)   .85 (.56-1.3)   .46   51 (42)   .89 (.59-1.3)   .56   48 (46)   1.1 (.72-1.7)   .65  
6bp−6bp−  82 (11)   23 (7)   .57 (.34-.94)   .02   4 (4)   .29 (.10-.82)   .01   9 (7)   .59 (.28-1.2)   .16   10 (10)   .87 (.42-1.8)   .71  
−/− vs +/−     .61 (.37-1.0)   .05    .34 (.12-.96)   .04    .67 (.32-1.4)   .29    .79 (.38-1.6)   .52  
SNA   4   4     1     0     2    
Total   731   337     108     122     107    
TYMS IVS6 - 68C>T              
CC   335 (46)   168 (50)   1.0   NA   58 (54)   1.0   NA   62 (51)   1.0   NA   48 (46)   1.0   NA  
CT   307 (42)   143 (43)   .92 (.71-1.2)   .59   46 (43)   .86 (.57-1.3)   .50   50 (41)   .88 (.58-1.3)   .53   47 (45)   1.1 (.69-1.6)   .76  
TT   83 (11)   22 (7)   .53 (.32-.88)   .01   4 (4)   .28 (.10-.80)   .01   9 (7)   .59 (.28-1.2)   .15   9 (9)   .76 (.36-1.6)   .47  
TT vs CT     .57 (.34-.95)   .03    .32 (.11-.92)   .03    .67 (.31-1.4)   .29    .71 (.33-1.5)   .37  
SNA   6   4     0     1     3    
Total   731   337     108     122     107    
TYMS 1053C>T              
CC   335 (46)   166 (49)   1.0   NA   58 (54)   1.0   NA   62 (51)   1.0   NA   46 (43)   1.0   NA  
CT   310 (43)   144 (43)   .94 (.71-1.2)   .64   45 (42)   .83 (.55-1.3)   .41   51 (42)   .89 (.59-1.3)   .56   48 (45)   1.1 (.73-1.7)   .59  
TT   83 (11)   26 (8)   .63 (.39-1.0)   .05   5 (5)   .34 (.13-.90)   .02   9 (7)   .59 (.28-1.2)   .15   12 (11)   1.0 (.53-2.1)   .88  
TT vs CT     .67 (.41-1.1)   .10    .41 (.16-1.1)   .07    .66 (.31-1.4)   .27    .93 (.47-1.8)   .84  
SNA   3   1     0     0     1    
Total   731   337     108     122     107    
TYMS 1122A>G              
AA   465 (64)   217 (65)   1.0   NA   71 (66)   1.0   NA   81 (67)   1.0   NA   65 (61)   1.0   NA  
AG   228 (31)   105 (31)   .99 (.74-1.3)   .93   33 (31)   .94 (.56-1.5)   .81   35 (29)   .88 (.57-1.3)   .56   37 (35)   1.2 (.75-1.8)   .50  
GG   35 (5)   12 (4)   .73 (.37-1.4)   .37   3 (3)   .56 (.17-1.9)   .90   5 (4)   .82 (.31-2.1)   .69   4 (4)   .82 (.28-2.4)   .14  
GG vs AG     .74 (.37-1.5)   .40    .59 (.17-2.0)   .40    .93 (.34-2.5)   .89    .70 (.23-2.1)   .53  
SNA   3   3     1     1     1    
Total   731   337     108     122     107    
MTHFR 677C>T              
CC   288 (40)   122 (37)   1.0   NA   37 (35)   1.0   NA   44 (36)   1.0   NA   41 (39)   1.0   NA  
CT   350 (48)   160 (48)   1.1 (.81-1.4)   .60   51 (48)   1.1 (.72-1.8)   .58   55 (45)   1.0 (.67-1.6)   .90   54 (51)   1.1 (.70-1.7)   .72  
TT   84 (12)   52 (16)   1.5 (.97-2.2)   .07   19 (18)   1.8 (.96-3.2)   .06   23 (19)   1.8 (1.0-3.1)   .04   10 (10)   .84 (.40-1.7)   .63  
SNA   9   3     1     0     2    
Total   731   337     108     122     107    
MTHFR 1298A>C              
AA   341 (47)   178 (53)   1.0   NA   59 (56)   1.0   NA   63 (52)   1.0   NA   56 (53)   1.0   NA  
AC   310 (43)   128 (38)   .79 (.60-1.0)   .09   38 (36)   .71 (.46-1.1)   .12   49 (40)   .86 (.57-1.3)   .45   41 (39)   .80 (.52-1.2)   .32  
CC   71 (10)   27 (8)   .73 (.45-1.2)   .19   9 (8)   .73 (.35-1.5)   .41   10 (8)   .76 (.37-1.6)   .46   8 (8)   .69 (.31-1.5)   .34  
SNA   9   4     2     0     2    
Total   731   337     108     122     107    
SHMT1 1420C>T              
CC   355 (49)   150 (45)   1.0   NA   47 (44)   1.0   NA   61 (50)   1.0   NA   42 (40)   1.0   NA  
CT   302 (41)   140 (42)   1.1 (.83-1.4)   .51   46 (43)   1.1 (.74-1.8)   .53   45 (37)   .87 (.57-1.3)   .50   49 (47)   1.4 (.88-2.1)   .16  
TT   72 (10)   43 (13)   1.4 (.92-2.2)   .11   14 (13)   1.5 (.77-2.8)   .24   16 (13)   1.3 (.70-2.4)   .40   13 (13)   1.5 (.78-3.0)   .21  
SNA   2   4     1     0     3    
Total   731   337     108     122     107    
MTR 2756A>G              
AA   489 (67)   201 (61)   1.0   NA   63 (60)   1.0   NA   76 (63)   1.0   NA   62 (59)   1.0   NA  
AG/GG   242 (33)   129 (39)   1.3 (.99-1.7)   .06   42 (40)   1.3 (.88-2.0)   .16   44 (37)   1.2 (.78-1.7)   .44   43 (41)   1.4 (.92-2.1)   .11  
SNA   0   7     3     2     2    
Total   731   337     108     122     107    
RFC 80G>A              
GG   266 (36)   109 (32)   1.0   NA   34 (32)   1.0   NA   37 (30)   1.0   NA   38 (36)   1.0   NA  
GA   331 (45)   158 (48)   1.2 (.87-1.6)   .31   55 (51)   1.3 (.82-2.0)   .26   57 (48)   1.2 (.79-1.9)   .35   46 (44)   .97 (.61-1.5)   .91  
AA   132 (18)   67 (20)   1.2 (.86-1.8)   .26   18 (17)   1.1 (.58-2.0)   .83   28 (23)   1.5 (.89-2.6)   .12   21 (20)   1.1 (.63-2.0)   .71  
SNA   2   3     1     0     2    
Total
 		 731
 		 337
 
 
 		 108
 
 
 		 122
 
 
 		 107
 
 
 
Control, no. (%)
All NHL cases
DLCL
FL
Other
Genotype
No. (%)
OR
P
No. (%)
OR
P
No. (%)
OR
P
No. (%)
OR
P
TYMS 3R → 2R              
3R/3R   209 (29)   97 (29)   1.1 (.77-1.6)   .53   29 (27)   1.0 (.55-1.8)   .99   33 (27)   1.2 (.66-2.1)   .56   35 (33)   1.2 (.68-2.1)   .53  
3R/2R   346 (48)   170 (51)   1.2 (.85-1.7)   .31   55 (52)   1.1 (.67-1.9)   .62   67 (55)   1.5 (.86-2.5)   .16   48 (46)   1.0 (.58-1.7)   .99  
2R/2R   158 (22)   65 (20)   1.0   NA   22 (21)   1.0   NA   21 (17)   1.0   NA   22 (21)   1.0   NA  
3R/3R vs 3R/2R     .94 (.70-1.3)   .71    .87 (.54-1.4)   .58    .81 (.52-1.3)   .37    1.2 (.76-1.9)   .43  
SNA   18   5     2     1     2    
Total   731   337     108     122     107    
TYMS 1494del6              
6bp+6bp+  335 (46)   166 (50)   1.0   NA   58 (54)   1.0   NA   62 (51)   1.0   NA   47 (45)   1.0   NA  
6bp+6bp−  310 (43)   144 (43)   .94 (.71-1.2)   .64   45 (42)   .85 (.56-1.3)   .46   51 (42)   .89 (.59-1.3)   .56   48 (46)   1.1 (.72-1.7)   .65  
6bp−6bp−  82 (11)   23 (7)   .57 (.34-.94)   .02   4 (4)   .29 (.10-.82)   .01   9 (7)   .59 (.28-1.2)   .16   10 (10)   .87 (.42-1.8)   .71  
−/− vs +/−     .61 (.37-1.0)   .05    .34 (.12-.96)   .04    .67 (.32-1.4)   .29    .79 (.38-1.6)   .52  
SNA   4   4     1     0     2    
Total   731   337     108     122     107    
TYMS IVS6 - 68C>T              
CC   335 (46)   168 (50)   1.0   NA   58 (54)   1.0   NA   62 (51)   1.0   NA   48 (46)   1.0   NA  
CT   307 (42)   143 (43)   .92 (.71-1.2)   .59   46 (43)   .86 (.57-1.3)   .50   50 (41)   .88 (.58-1.3)   .53   47 (45)   1.1 (.69-1.6)   .76  
TT   83 (11)   22 (7)   .53 (.32-.88)   .01   4 (4)   .28 (.10-.80)   .01   9 (7)   .59 (.28-1.2)   .15   9 (9)   .76 (.36-1.6)   .47  
TT vs CT     .57 (.34-.95)   .03    .32 (.11-.92)   .03    .67 (.31-1.4)   .29    .71 (.33-1.5)   .37  
SNA   6   4     0     1     3    
Total   731   337     108     122     107    
TYMS 1053C>T              
CC   335 (46)   166 (49)   1.0   NA   58 (54)   1.0   NA   62 (51)   1.0   NA   46 (43)   1.0   NA  
CT   310 (43)   144 (43)   .94 (.71-1.2)   .64   45 (42)   .83 (.55-1.3)   .41   51 (42)   .89 (.59-1.3)   .56   48 (45)   1.1 (.73-1.7)   .59  
TT   83 (11)   26 (8)   .63 (.39-1.0)   .05   5 (5)   .34 (.13-.90)   .02   9 (7)   .59 (.28-1.2)   .15   12 (11)   1.0 (.53-2.1)   .88  
TT vs CT     .67 (.41-1.1)   .10    .41 (.16-1.1)   .07    .66 (.31-1.4)   .27    .93 (.47-1.8)   .84  
SNA   3   1     0     0     1    
Total   731   337     108     122     107    
TYMS 1122A>G              
AA   465 (64)   217 (65)   1.0   NA   71 (66)   1.0   NA   81 (67)   1.0   NA   65 (61)   1.0   NA  
AG   228 (31)   105 (31)   .99 (.74-1.3)   .93   33 (31)   .94 (.56-1.5)   .81   35 (29)   .88 (.57-1.3)   .56   37 (35)   1.2 (.75-1.8)   .50  
GG   35 (5)   12 (4)   .73 (.37-1.4)   .37   3 (3)   .56 (.17-1.9)   .90   5 (4)   .82 (.31-2.1)   .69   4 (4)   .82 (.28-2.4)   .14  
GG vs AG     .74 (.37-1.5)   .40    .59 (.17-2.0)   .40    .93 (.34-2.5)   .89    .70 (.23-2.1)   .53  
SNA   3   3     1     1     1    
Total   731   337     108     122     107    
MTHFR 677C>T              
CC   288 (40)   122 (37)   1.0   NA   37 (35)   1.0   NA   44 (36)   1.0   NA   41 (39)   1.0   NA  
CT   350 (48)   160 (48)   1.1 (.81-1.4)   .60   51 (48)   1.1 (.72-1.8)   .58   55 (45)   1.0 (.67-1.6)   .90   54 (51)   1.1 (.70-1.7)   .72  
TT   84 (12)   52 (16)   1.5 (.97-2.2)   .07   19 (18)   1.8 (.96-3.2)   .06   23 (19)   1.8 (1.0-3.1)   .04   10 (10)   .84 (.40-1.7)   .63  
SNA   9   3     1     0     2    
Total   731   337     108     122     107    
MTHFR 1298A>C              
AA   341 (47)   178 (53)   1.0   NA   59 (56)   1.0   NA   63 (52)   1.0   NA   56 (53)   1.0   NA  
AC   310 (43)   128 (38)   .79 (.60-1.0)   .09   38 (36)   .71 (.46-1.1)   .12   49 (40)   .86 (.57-1.3)   .45   41 (39)   .80 (.52-1.2)   .32  
CC   71 (10)   27 (8)   .73 (.45-1.2)   .19   9 (8)   .73 (.35-1.5)   .41   10 (8)   .76 (.37-1.6)   .46   8 (8)   .69 (.31-1.5)   .34  
SNA   9   4     2     0     2    
Total   731   337     108     122     107    
SHMT1 1420C>T              
CC   355 (49)   150 (45)   1.0   NA   47 (44)   1.0   NA   61 (50)   1.0   NA   42 (40)   1.0   NA  
CT   302 (41)   140 (42)   1.1 (.83-1.4)   .51   46 (43)   1.1 (.74-1.8)   .53   45 (37)   .87 (.57-1.3)   .50   49 (47)   1.4 (.88-2.1)   .16  
TT   72 (10)   43 (13)   1.4 (.92-2.2)   .11   14 (13)   1.5 (.77-2.8)   .24   16 (13)   1.3 (.70-2.4)   .40   13 (13)   1.5 (.78-3.0)   .21  
SNA   2   4     1     0     3    
Total   731   337     108     122     107    
MTR 2756A>G              
AA   489 (67)   201 (61)   1.0   NA   63 (60)   1.0   NA   76 (63)   1.0   NA   62 (59)   1.0   NA  
AG/GG   242 (33)   129 (39)   1.3 (.99-1.7)   .06   42 (40)   1.3 (.88-2.0)   .16   44 (37)   1.2 (.78-1.7)   .44   43 (41)   1.4 (.92-2.1)   .11  
SNA   0   7     3     2     2    
Total   731   337     108     122     107    
RFC 80G>A              
GG   266 (36)   109 (32)   1.0   NA   34 (32)   1.0   NA   37 (30)   1.0   NA   38 (36)   1.0   NA  
GA   331 (45)   158 (48)   1.2 (.87-1.6)   .31   55 (51)   1.3 (.82-2.0)   .26   57 (48)   1.2 (.79-1.9)   .35   46 (44)   .97 (.61-1.5)   .91  
AA   132 (18)   67 (20)   1.2 (.86-1.8)   .26   18 (17)   1.1 (.58-2.0)   .83   28 (23)   1.5 (.89-2.6)   .12   21 (20)   1.1 (.63-2.0)   .71  
SNA   2   3     1     0     2    
Total
 		 731
 		 337
 
 
 		 108
 
 
 		 122
 
 
 		 107
 
 
 

DLCL indicates diffuse large cell lymphoma; FL, follicular lymphoma; NA, not applicable; and SNA, samples not amplified.

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