DC chemokine receptors and chemokines
Receptors . | Receptor expression on DCs . | Ligands . | Ligand expression by DCs . | Notes . |
|---|---|---|---|---|
| CCR1 and CCR5 | Immature DCs | CCL3 (MIP-1α) | Mature DCs (some stimuli only) | CCL3, 4, and 5 are also secreted by activated inflammatory cells and activated endothelium |
| CCL4 (MIP-1β) | ||||
| CCL5 (RANTES) | ||||
| CCR2 | Immature DCs | CCL2 (MCP-1) | Not expressed | CCL2 is secreted by activated monocytes, macrophages and endothelium |
| CCR4 | Immature DCs | CCL17 (TARC) | Mature DCs (some stimuli only) | CCR4 is preferentially expressed on Th2 cells, and TARC and MDC can promote Th2 responses. |
| CCL22 (MDC) | ||||
| CCR6 | Immature DCs (some subsets only) | CCL20 (MIP-3α) | Not expressed | CCL20 is expressed by activated monocytes and lymphocytes |
| CCR7 | Mature DCs | CCL19 (MIP-3β) | Not expressed | CCL19 and 21 are expressed in T-cell zones of lymph nodes and spleen, lymphatic endothelium, and lymph node high endothelial venules |
| CCL21 (SLC) | ||||
| CXCR1 and CXCR2 | Immature DCs | CXCL8 (IL-8) | Mature DCs | IL-8 is a mediator of neutrophil recruitment |
| CXCR3 | Not expressed | CXCL10 (IP-10) | Mature DCs (some stimuli only) | IP-10 attracts IFNγ-producing T cells, which express CXCR3, and can promote Th1 responses. |
| CXCR4 | Mature > Immature | CXCL12 (SDF-1) | Not expressed | SDF-1 is a chemoattractant for lymphocytes and monocytes. CXCR4 is also a coreceptor for T-cell-trophic strains of HIV |
Receptors . | Receptor expression on DCs . | Ligands . | Ligand expression by DCs . | Notes . |
|---|---|---|---|---|
| CCR1 and CCR5 | Immature DCs | CCL3 (MIP-1α) | Mature DCs (some stimuli only) | CCL3, 4, and 5 are also secreted by activated inflammatory cells and activated endothelium |
| CCL4 (MIP-1β) | ||||
| CCL5 (RANTES) | ||||
| CCR2 | Immature DCs | CCL2 (MCP-1) | Not expressed | CCL2 is secreted by activated monocytes, macrophages and endothelium |
| CCR4 | Immature DCs | CCL17 (TARC) | Mature DCs (some stimuli only) | CCR4 is preferentially expressed on Th2 cells, and TARC and MDC can promote Th2 responses. |
| CCL22 (MDC) | ||||
| CCR6 | Immature DCs (some subsets only) | CCL20 (MIP-3α) | Not expressed | CCL20 is expressed by activated monocytes and lymphocytes |
| CCR7 | Mature DCs | CCL19 (MIP-3β) | Not expressed | CCL19 and 21 are expressed in T-cell zones of lymph nodes and spleen, lymphatic endothelium, and lymph node high endothelial venules |
| CCL21 (SLC) | ||||
| CXCR1 and CXCR2 | Immature DCs | CXCL8 (IL-8) | Mature DCs | IL-8 is a mediator of neutrophil recruitment |
| CXCR3 | Not expressed | CXCL10 (IP-10) | Mature DCs (some stimuli only) | IP-10 attracts IFNγ-producing T cells, which express CXCR3, and can promote Th1 responses. |
| CXCR4 | Mature > Immature | CXCL12 (SDF-1) | Not expressed | SDF-1 is a chemoattractant for lymphocytes and monocytes. CXCR4 is also a coreceptor for T-cell-trophic strains of HIV |
CCR indicates CC motif chemokine receptor; CCL, CC motif chemokine ligand; MIP, macrophage inflammatory protein; RANTES, regulated on activation, normally T-expressed, and presumably secreted; MCP, monocyte chemoattractant protein; TARC, thymus and activation-regulated chemokine; MDC, macrophage-derived chemokine; SLC, secondary lymphoid chemokine; CXCR, CXC motif chemokine receptor; CXCL, CXC motif chemokine ligand; IP-10, IFNγ-inducible 10-kDa protein; SDF-1, stromal cell-derived factor 1; HIV, human immunodeficiency virus.