DC antigen uptake receptors
Receptor class . | Examples . | Ligands . | Notes . |
|---|---|---|---|
| C-type lectin-like receptors16 | DC-SIGN (CD209) | Viruses (HIV, Dengue, Ebola), mycobacteria | DC-SIGN also binds adhesion molecules (ICAM-2 and -3) that are important in DC trafficking and cell-cell interactions. |
| MMR (MRC1) | Mannosylated molecules | ||
| DEC-205 (LY75) | ? | ||
| BDCA-2 (CLECSF11) | ? | ||
| Langerin | ? | ||
| Dectin-1 | β-glucan | ||
| Fc receptors | FcγRI (CD32) | Immune complexes and opsonized cells | — |
| FcγRII (CD64) | |||
| Integrins | αVβ5 | Apoptotic cells | CR3 binds ICAM-1, found on activated lymphocytes and endothelial cells. |
| αMβ2 (CD11b/CD18, CR3) | Opsonized antigens (via iC3b), bacteria | ||
| αXβ2 (CD11c/CD18, CR4) | Opsonized antigens (via iC3b) | ||
| Scavenger receptors17 | CD36 | Apoptotic cells | Heat shock proteins (Hsps) are highly conserved molecules that are released by dying cells and that can mature DCs. Their normal function is to chaperone peptides between subcellular compartments.17,18 |
| LOX-1 (OLR1) | Hsp-peptide complexes | ||
| Other | CD9119 | Hsp-peptide complexes | — |
| Aquaporins | Fluids |
Receptor class . | Examples . | Ligands . | Notes . |
|---|---|---|---|
| C-type lectin-like receptors16 | DC-SIGN (CD209) | Viruses (HIV, Dengue, Ebola), mycobacteria | DC-SIGN also binds adhesion molecules (ICAM-2 and -3) that are important in DC trafficking and cell-cell interactions. |
| MMR (MRC1) | Mannosylated molecules | ||
| DEC-205 (LY75) | ? | ||
| BDCA-2 (CLECSF11) | ? | ||
| Langerin | ? | ||
| Dectin-1 | β-glucan | ||
| Fc receptors | FcγRI (CD32) | Immune complexes and opsonized cells | — |
| FcγRII (CD64) | |||
| Integrins | αVβ5 | Apoptotic cells | CR3 binds ICAM-1, found on activated lymphocytes and endothelial cells. |
| αMβ2 (CD11b/CD18, CR3) | Opsonized antigens (via iC3b), bacteria | ||
| αXβ2 (CD11c/CD18, CR4) | Opsonized antigens (via iC3b) | ||
| Scavenger receptors17 | CD36 | Apoptotic cells | Heat shock proteins (Hsps) are highly conserved molecules that are released by dying cells and that can mature DCs. Their normal function is to chaperone peptides between subcellular compartments.17,18 |
| LOX-1 (OLR1) | Hsp-peptide complexes | ||
| Other | CD9119 | Hsp-peptide complexes | — |
| Aquaporins | Fluids |
DC-SIGN indicates dendritic cell-specific ICAM-3-grabbing nonintegrin; ICAM-2, intracellular adhesion molecule 2; MMR, macrophage mannose receptor; BDCA, blood dendritic cell antigen; CR, complement receptor; LOX-1, low density lipoprotein, oxidized, receptor 1; and CLECSF, C-type lectin superfamily. Antigen uptake by way of DEC-205,20 Fcγ receptors,135 αVβ5 integrin,21 CD36,21 LOX-1,18 and CD9119 have all been associated with cross-presentation.