Impact of HLA mismatching at specific loci on transplant-related outcomes: associations between HLA mismatch (high- or low-resolution) at specific loci and outcome after unrelated donor BMT
. | . | Engraftment . | . | . | Grade III-IV acute GVHD . | . | . | Chronic GVHD . | . | . | Mortality . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mismatched locus . | No. . | OR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||||||||
| HLA-A | 374 | 0.68 | (0.39, 1.22) | .20 | 1.41 | (1.16, 1.71) | .0005 | 1.35 | (1.09, 1.66) | .006 | 1.33 | (1.15, 1.54) | .0002 | ||||||||
| HLA-B | 477 | 1.07 | (0.61, 1.88) | .82 | 1.24 | (1.03, 1.50) | .03 | 1.04 | (0.84, 1.30) | .71 | 1.22 | (1.06, 1.41) | .007 | ||||||||
| HLA-C | 749 | 0.54 | (0.33, 0.89) | .02 | 1.19 | (1.00, 1.41) | .05 | 1.01 | (0.84, 1.21) | .92 | 1.21 | (1.06, 1.38) | .005 | ||||||||
| HLA-DRB1 | 311 | 1.07 | (0.57, 2.02) | .83 | 1.26 | (1.01, 1.56) | .04 | 1.27 | (0.99, 1.64) | .07 | 1.23 | (1.04, 1.45) | .01 | ||||||||
| HLA-DQ | 415 | 0.67 | (0.39, 1.14) | .14 | 1.03 | (0.85, 1.26) | .76 | 0.93 | (0.74, 1.16) | .50 | 0.98 | (0.84, 1.14) | .80 | ||||||||
| HLA-DP | 1648 | 0.69 | (0.38, 1.25) | .22 | 1.19 | (0.99, 1.43) | .06 | 1.17 | (0.98, 1.39) | .08 | 1.07 | (0.89, 1.27) | .48 | ||||||||
. | . | Engraftment . | . | . | Grade III-IV acute GVHD . | . | . | Chronic GVHD . | . | . | Mortality . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mismatched locus . | No. . | OR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||||||||
| HLA-A | 374 | 0.68 | (0.39, 1.22) | .20 | 1.41 | (1.16, 1.71) | .0005 | 1.35 | (1.09, 1.66) | .006 | 1.33 | (1.15, 1.54) | .0002 | ||||||||
| HLA-B | 477 | 1.07 | (0.61, 1.88) | .82 | 1.24 | (1.03, 1.50) | .03 | 1.04 | (0.84, 1.30) | .71 | 1.22 | (1.06, 1.41) | .007 | ||||||||
| HLA-C | 749 | 0.54 | (0.33, 0.89) | .02 | 1.19 | (1.00, 1.41) | .05 | 1.01 | (0.84, 1.21) | .92 | 1.21 | (1.06, 1.38) | .005 | ||||||||
| HLA-DRB1 | 311 | 1.07 | (0.57, 2.02) | .83 | 1.26 | (1.01, 1.56) | .04 | 1.27 | (0.99, 1.64) | .07 | 1.23 | (1.04, 1.45) | .01 | ||||||||
| HLA-DQ | 415 | 0.67 | (0.39, 1.14) | .14 | 1.03 | (0.85, 1.26) | .76 | 0.93 | (0.74, 1.16) | .50 | 0.98 | (0.84, 1.14) | .80 | ||||||||
| HLA-DP | 1648 | 0.69 | (0.38, 1.25) | .22 | 1.19 | (0.99, 1.43) | .06 | 1.17 | (0.98, 1.39) | .08 | 1.07 | (0.89, 1.27) | .48 | ||||||||
Shown are results of multivariate analysis including odds ratio (OR) for engraftment and relative risk (RR) for GVHD and mortality, 95% confidence intervals (CI), and P values associated with mismatching at each locus. Statistically significant associations are shown in boldface. HLA-A mismatching showed significant associations (boldface) with acute GVHD, chronic GVHD, and mortality. HLA-B, -C, and -DR showed significant associations with mortality. Mismatch at HLA-C showed a trend to association with poorer engraftment, although not reaching the significance threshold defined for this study. Mismatched HLA-B, -C, -DR all showed trends to more frequent acute GVHD.