Generation of mouse models for human bone marrow failure syndrome
Donor . | Recipient . | N . | TBI + LN cells/mouse . | Results . |
|---|---|---|---|---|
| Experiment 1 | ||||
| None | B6D2F1 | 2 | 0 Gy + 0 | Alive and healthy |
| None | B6D2F1 | 5 | 6 Gy + 0 | Lymphocytopenia |
| B6 | B6D2F1 | 5 | 5 Gy + 10 × 106 | Anemia, marrow aplasia, lymphopenia |
| B6 | B6D2F1 | 5 | 6 Gy + 10 × 10 | 4 dead by day 12 |
| Experiment 2 | ||||
| None | CByB6F1 | 5 | 0 Gy + 0 | Alive and healthy |
| B6 | CByB6F1 | 6 | 5 Gy + 10 × 106 | All dead by day 14 |
| B6 | CByB6F1 | 4 | 5 Gy + 5 × 106 | All dead by day 14 |
| Experiment 3 | ||||
| None | CByB6F1 | 5 | 0 Gy + 0 | Alive and healthy |
| None | CByB6F1 | 5 | 5 Gy + 0 | Lymphocytopenia |
| B6 | CByB6F1 | 15 | 5 Gy + 5 × 106 | 7 dead by days 14-21, pancytopenia |
| Experiment 4 | ||||
| None | CByB6F1 | 4 | 0 Gy + 0 | Alive and healthy |
| None | CByB6F1 | 5 | 5 Gy + 0 | Lymphocytopenia |
| B6 | CByB6F1 | 10 | 5 Gy + 5 × 106 | 8 dead by day 14, pancytopenia |
| BALB | CByB6F1 | 5 | 5 Gy + 10 × 106 | Lymphocytopenia |
Donor . | Recipient . | N . | TBI + LN cells/mouse . | Results . |
|---|---|---|---|---|
| Experiment 1 | ||||
| None | B6D2F1 | 2 | 0 Gy + 0 | Alive and healthy |
| None | B6D2F1 | 5 | 6 Gy + 0 | Lymphocytopenia |
| B6 | B6D2F1 | 5 | 5 Gy + 10 × 106 | Anemia, marrow aplasia, lymphopenia |
| B6 | B6D2F1 | 5 | 6 Gy + 10 × 10 | 4 dead by day 12 |
| Experiment 2 | ||||
| None | CByB6F1 | 5 | 0 Gy + 0 | Alive and healthy |
| B6 | CByB6F1 | 6 | 5 Gy + 10 × 106 | All dead by day 14 |
| B6 | CByB6F1 | 4 | 5 Gy + 5 × 106 | All dead by day 14 |
| Experiment 3 | ||||
| None | CByB6F1 | 5 | 0 Gy + 0 | Alive and healthy |
| None | CByB6F1 | 5 | 5 Gy + 0 | Lymphocytopenia |
| B6 | CByB6F1 | 15 | 5 Gy + 5 × 106 | 7 dead by days 14-21, pancytopenia |
| Experiment 4 | ||||
| None | CByB6F1 | 4 | 0 Gy + 0 | Alive and healthy |
| None | CByB6F1 | 5 | 5 Gy + 0 | Lymphocytopenia |
| B6 | CByB6F1 | 10 | 5 Gy + 5 × 106 | 8 dead by day 14, pancytopenia |
| BALB | CByB6F1 | 5 | 5 Gy + 10 × 106 | Lymphocytopenia |