Table 2. IC 50 of imatinib in primary Ph... | American Society of Hematology

Table 2.

IC₅₀ of imatinib in primary Ph⁺ ALL cells

		IC₅₀, μM
Sample	Mutation in BCR-ABL	PEG-liposome	CD19-liposome	Free imatinib
Ph⁺ ALL-1	WT	5.93 ± 0.73*	< 0.01	< 0.01
Ph⁺ ALL-2	WT	> 10.0	0.01 ± 0.01*	0.04 ± 0.02*
Ph⁺ ALL-3	Y253H	> 10.0	0.30 ± 0.06*	3.18 ± 0.78*
Ph⁺ ALL-4	Y253H	> 10.0	0.07 ± 0.06*	3.34 ± 0.98*

		IC₅₀, μM
Sample	Mutation in BCR-ABL	PEG-liposome	CD19-liposome	Free imatinib
Ph⁺ ALL-1	WT	5.93 ± 0.73*	< 0.01	< 0.01
Ph⁺ ALL-2	WT	> 10.0	0.01 ± 0.01*	0.04 ± 0.02*
Ph⁺ ALL-3	Y253H	> 10.0	0.30 ± 0.06*	3.18 ± 0.78*
Ph⁺ ALL-4	Y253H	> 10.0	0.07 ± 0.06*	3.34 ± 0.98*

WT indicates wild type. Y253H indicates that the 253rd tyrosine was substituted by histidine.

Data represent mean ± SD of triplicate experiments.