Summary of clinical data on study patients by FLT3 mutation status
Characteristics . | ITD, N = 15 . | PM, N = 15 . | WT, N = 14 . | P . |
|---|---|---|---|---|
| Median age, y | 12.6 | 9.4 | 7.2 | .2820 |
| Median WBCs per 103/mm3 | 90.0 | 13.3 | 30.1 | .0190* |
| Cytogenetics, no. patients (%) | ||||
| Favorable [t(8;21), inv(16), t(16;16), del(16)] | 2 (13) | 3 (20) | 2 (14) | .8652 |
| Intermediate [nl, aneuploid, +8, abn(11q23)] | 5 (33) | 8 (53) | 6 (43) | .5424 |
| Adverse [-5, del(5q), -7, abn(3q)] | 0 (0) | 0 (0) | 0 (0) | NA |
| Not available | 8 (53) | 4 (27) | 6 (43) | .3265 |
| FAB classification, no. patients (%) | ||||
| M0 | 0 (0) | 2 (13) | 1 (17) | .3496 |
| M1 | 2 (13) | 3 (20) | 1 (7) | .601 |
| M2 | 7 (47) | 3 (20) | 2 (14) | .1089 |
| M4 | 4 (27) | 3 (20) | 3 (21) | .9005 |
| M5 | 2 (13) | 4 (27) | 6 (43) | .2033 |
| M7 | 0 (0) | 0 (0) | 1 (7) | .3341 |
| Percent induction CR | 79% | 87% | 86% | .8152 |
| Overall survival from DX at 5 years | 15% | 67% | 76% | .0018* |
| Relapse-free survival from CR at 5 years | 20% | 58% | 73% | .0059* |
Characteristics . | ITD, N = 15 . | PM, N = 15 . | WT, N = 14 . | P . |
|---|---|---|---|---|
| Median age, y | 12.6 | 9.4 | 7.2 | .2820 |
| Median WBCs per 103/mm3 | 90.0 | 13.3 | 30.1 | .0190* |
| Cytogenetics, no. patients (%) | ||||
| Favorable [t(8;21), inv(16), t(16;16), del(16)] | 2 (13) | 3 (20) | 2 (14) | .8652 |
| Intermediate [nl, aneuploid, +8, abn(11q23)] | 5 (33) | 8 (53) | 6 (43) | .5424 |
| Adverse [-5, del(5q), -7, abn(3q)] | 0 (0) | 0 (0) | 0 (0) | NA |
| Not available | 8 (53) | 4 (27) | 6 (43) | .3265 |
| FAB classification, no. patients (%) | ||||
| M0 | 0 (0) | 2 (13) | 1 (17) | .3496 |
| M1 | 2 (13) | 3 (20) | 1 (7) | .601 |
| M2 | 7 (47) | 3 (20) | 2 (14) | .1089 |
| M4 | 4 (27) | 3 (20) | 3 (21) | .9005 |
| M5 | 2 (13) | 4 (27) | 6 (43) | .2033 |
| M7 | 0 (0) | 0 (0) | 1 (7) | .3341 |
| Percent induction CR | 79% | 87% | 86% | .8152 |
| Overall survival from DX at 5 years | 15% | 67% | 76% | .0018* |
| Relapse-free survival from CR at 5 years | 20% | 58% | 73% | .0059* |
WBC indicates white blood cells; FAB, French-American-British; CR, complete remission; DX, diagnosis; and NA, not available.
Indicates statistically significant.