Nonmyeloablative transplant threshold reductions in c-Mpl–/– and c-Mpl–/–KitWv/+ mice
Recipient genotype and no. cells transplanted . | Mice lymphomyeloid repopulated, no./total . | . | . | ||
|---|---|---|---|---|---|
| . | 3 wk . | 6 wk . | 12 wk . | ||
| c-Mpl+/+Kit+/+ | |||||
| 6 × 104 | 0/4 | 0/4 | 0/4 | ||
| 6 × 105 | 0/4 | 0/4 | 0/4 | ||
| 6 × 106 | 0/4 | 0/4 | 0/4 | ||
| 107 | 0/4 | 0/4 | 0/4 | ||
| 6 × 107 | 0/4 | 0/4 | 0/4 | ||
| 108 | 4/4 | 3/4 | 2/4 | ||
| 2 × 108 | 2/2 | 2/2 | 2/2 | ||
| c-Mpl-/-Kit+/+ | |||||
| 6 × 104 | 0/4 | 0/4 | 0/4 | ||
| 6 × 105 | 0/4 | 0/4 | 0/4 | ||
| 106 | 0/15 | 0/15 | 0/15 | ||
| 6 × 106 | 3/4 | 1/4 | 0/4 | ||
| 6 × 107 | 1/4 | 1/4 | 1/4 | ||
| c-Mpl+/+KitWv/+ | |||||
| 6 × 105 | 0/4 | 0/4 | 0/4 | ||
| 106 | 0/4 | 0/4 | 0/4 | ||
| 107 | 2/5 | 0/5 | 0/5 | ||
| c-Mpl-/-KitWv/+ | |||||
| 6 × 104 | 0/4 | 0/4 | 0/4 | ||
| 6 × 105 | 0/9 | 0/9 | 0/9 | ||
| 106 | 2/14 | 1/14 | 1/14 | ||
| 6 × 106 | 8/8 | 4/8 | 1/8 | ||
Recipient genotype and no. cells transplanted . | Mice lymphomyeloid repopulated, no./total . | . | . | ||
|---|---|---|---|---|---|
| . | 3 wk . | 6 wk . | 12 wk . | ||
| c-Mpl+/+Kit+/+ | |||||
| 6 × 104 | 0/4 | 0/4 | 0/4 | ||
| 6 × 105 | 0/4 | 0/4 | 0/4 | ||
| 6 × 106 | 0/4 | 0/4 | 0/4 | ||
| 107 | 0/4 | 0/4 | 0/4 | ||
| 6 × 107 | 0/4 | 0/4 | 0/4 | ||
| 108 | 4/4 | 3/4 | 2/4 | ||
| 2 × 108 | 2/2 | 2/2 | 2/2 | ||
| c-Mpl-/-Kit+/+ | |||||
| 6 × 104 | 0/4 | 0/4 | 0/4 | ||
| 6 × 105 | 0/4 | 0/4 | 0/4 | ||
| 106 | 0/15 | 0/15 | 0/15 | ||
| 6 × 106 | 3/4 | 1/4 | 0/4 | ||
| 6 × 107 | 1/4 | 1/4 | 1/4 | ||
| c-Mpl+/+KitWv/+ | |||||
| 6 × 105 | 0/4 | 0/4 | 0/4 | ||
| 106 | 0/4 | 0/4 | 0/4 | ||
| 107 | 2/5 | 0/5 | 0/5 | ||
| c-Mpl-/-KitWv/+ | |||||
| 6 × 104 | 0/4 | 0/4 | 0/4 | ||
| 6 × 105 | 0/9 | 0/9 | 0/9 | ||
| 106 | 2/14 | 1/14 | 1/14 | ||
| 6 × 106 | 8/8 | 4/8 | 1/8 | ||