Table 2. Megakaryopoiesis in c-Mpl and... | American Society of Hematology

Table 2.

Megakaryopoiesis in c-Mpl and Kit mutants

		Mk, per 10 hpf			CFU-Mk
Genotype	Plt, × 10⁹/L	BM	Spleen	BM, per 25 000 cells	Spleen, per 100 000 cells
c-Mpl^+/+Kit^+/+	1176 ± 121	45.6 ± 7.4	4.3 ± 3.3	12.6 ± 4.3	4.9 ± 2.6
c-Mpl^-/-	95 ± 52*	11.3 ± 8.4*	0.8 ± 0.7	3.8 ± 2.3*	4.4 ± 2.4
Kit^Wv/Wv	1211 ± 288	35.4 ± 14.2	2.6 ± 2.1	6.4 ± 3.4	0.9 ± 1.2*
c-Mpl^-/-Kit^Wv/Wv	143 ± 52*	4.7 ± 2.6*	1.2 ± 1.3	2.2 ± 2.1*^‡	0.4 ± 0.6*^†

		Mk, per 10 hpf			CFU-Mk
Genotype	Plt, × 10⁹/L	BM	Spleen	BM, per 25 000 cells	Spleen, per 100 000 cells
c-Mpl^+/+Kit^+/+	1176 ± 121	45.6 ± 7.4	4.3 ± 3.3	12.6 ± 4.3	4.9 ± 2.6
c-Mpl^-/-	95 ± 52*	11.3 ± 8.4*	0.8 ± 0.7	3.8 ± 2.3*	4.4 ± 2.4
Kit^Wv/Wv	1211 ± 288	35.4 ± 14.2	2.6 ± 2.1	6.4 ± 3.4	0.9 ± 1.2*
c-Mpl^-/-Kit^Wv/Wv	143 ± 52*	4.7 ± 2.6*	1.2 ± 1.3	2.2 ± 2.1*^‡	0.4 ± 0.6*^†

Plt indicates platelet count; hpf, high-powered fields; and BM, bone marrow. Values are means ± SD.

P < .001 versus wild type.

P < .001 versus c-Mpl^-/-.

P < .001 versus Kit^Wv/Wv.