Rate of de novo purine synthesis (DNPS) in leukemia cells of different lineage, ploidy, and genetic subtypes of ALL
Subtype . | No. of patients . | Median DNPS rate, fmol/nmol/h (range) . |
|---|---|---|
| T-ALL | 17 | 1315 (515-5018) |
| B-hyperdiploid | 26 | 1023 (34-2474) |
| E2A-PBX | 7 | 941 (367-2048) |
| TEL-AML1 | 30 | 326 (11-1104) |
| B-other | 33 | 873 (40-5933) |
Subtype . | No. of patients . | Median DNPS rate, fmol/nmol/h (range) . |
|---|---|---|
| T-ALL | 17 | 1315 (515-5018) |
| B-hyperdiploid | 26 | 1023 (34-2474) |
| E2A-PBX | 7 | 941 (367-2048) |
| TEL-AML1 | 30 | 326 (11-1104) |
| B-other | 33 | 873 (40-5933) |