Table 1.

Candidate Myb gene targets




Accession no.*

Fold change
Genes suppressed by Myb   
    Hemoglobin, delta  NM_000519  4.3  
    Transferrin  M12530  3.2  
    B-cell CLL/lymphoma  NM_001706  3.1  
    B-cell translocation gene 2  U72649  3.0  
    Platelet glycoprotein IIIa  M35999  2.6  
Genes up-regulated by Myb   
    Neuromedin U  NM_006681  4.9  
    Schneider fetal brain 00004 Homo sapiens cDNA clone  AI816485  4.3  
    cdc7  AF015592  2.8  
    Heat shock 60-kDa protein 1 (chaperonin)  NM_002156  2.8  
    Histone H3
 
AI928823
 
2.6
 



Accession no.*

Fold change
Genes suppressed by Myb   
    Hemoglobin, delta  NM_000519  4.3  
    Transferrin  M12530  3.2  
    B-cell CLL/lymphoma  NM_001706  3.1  
    B-cell translocation gene 2  U72649  3.0  
    Platelet glycoprotein IIIa  M35999  2.6  
Genes up-regulated by Myb   
    Neuromedin U  NM_006681  4.9  
    Schneider fetal brain 00004 Homo sapiens cDNA clone  AI816485  4.3  
    cdc7  AF015592  2.8  
    Heat shock 60-kDa protein 1 (chaperonin)  NM_002156  2.8  
    Histone H3
 
AI928823
 
2.6
 

Ten of the 105 genes that changed in expression more than 2-fold in tamoxifen treated K562-MERT cells compared to untreated cells are provided. The complete microarray data set was deposited in ArrayExpress (http://www.ebi.ac.uk/arrayexpress/). The accession number for the data set is E-MEXP-91.

*

Accession number is the GenBank accession number corresponding to each gene.

The 5 genes listed to be suppressed by Myb are among the genes that increased the most in expression in tamoxifen treated K562-MERT cells as determined by microarray analysis.

The 5 genes listed to be up-regulated by Myb are among the genes that decreased in expression to the greatest extent in tamoxifen treated K562-MERT cells following microarray analysis.

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