Evaluation of LOH of AML1 in patients with AML1 mutations and clonal makers
Case no. . | FISH for AML1, 2 signals/3 signals . | Clonal marker . | Cytogenetically abnormal/normal mitoses . | Interphase FISH for 5q or 7q, 1 signal/2 signals . | AML1 alleles, mutated/wild type . |
|---|---|---|---|---|---|
| 16 | 25/0 | -7 | 13/7 | 103/97 | 5/11 |
| 38 | 25/0 | 7q- | 45/0 | 198/2 | 6/10 |
| 40 | 23/0 | -7 | 18/24 | 75/125 | 9/5 |
| 45 | 25/0 | 5q- | NA | 133/67 | 4/11 |
| 50 | 3/25 | -7 | 22/2 | 159/41 | 11/4 |
| 62 | 11/14 | -7 | 11/12 | 142/58 | 4/12 |
| 71 | 14/0 | 7q- | 27/0 | 163/37 | 10/6 |
| 72 | 7/13 | 7q- | 33/0 | 163/37 | 5/11 |
| 93 | 23/0 | 7q- | 29/0 | 165/35 | 5/7 |
| 97 | 6/4 | -7 | 16/5 | 125/75 | 6/9 |
| 98 | 27/0 | -7 | 28/0 | 132/68 | 10/4 |
| 104 | 21/0 | 7q- | 32/0 | 146/54 | 6/10 |
| 108 | NA | -7 | 20/2 | NA | 8/8 |
| 114 | 28/0 | 7q- | 16/12 | 138/62 | 9/7 |
| 117 | 25/0 | 7q- | 19/6 | 147/53 | 2/13 |
| 128 | 20/0 | -7 | 30/0 | 180/20 | 6/8 |
| 154 | 36/0 | 7q- | 24/1 | 145/55 | 6/7 |
| 160 | 27/0 | 5q- | 6/23 | 94/106 | 6/13 |
| 165 | 29/0 | 7q- | 27/0 | 192/8 | 9/10 |
Case no. . | FISH for AML1, 2 signals/3 signals . | Clonal marker . | Cytogenetically abnormal/normal mitoses . | Interphase FISH for 5q or 7q, 1 signal/2 signals . | AML1 alleles, mutated/wild type . |
|---|---|---|---|---|---|
| 16 | 25/0 | -7 | 13/7 | 103/97 | 5/11 |
| 38 | 25/0 | 7q- | 45/0 | 198/2 | 6/10 |
| 40 | 23/0 | -7 | 18/24 | 75/125 | 9/5 |
| 45 | 25/0 | 5q- | NA | 133/67 | 4/11 |
| 50 | 3/25 | -7 | 22/2 | 159/41 | 11/4 |
| 62 | 11/14 | -7 | 11/12 | 142/58 | 4/12 |
| 71 | 14/0 | 7q- | 27/0 | 163/37 | 10/6 |
| 72 | 7/13 | 7q- | 33/0 | 163/37 | 5/11 |
| 93 | 23/0 | 7q- | 29/0 | 165/35 | 5/7 |
| 97 | 6/4 | -7 | 16/5 | 125/75 | 6/9 |
| 98 | 27/0 | -7 | 28/0 | 132/68 | 10/4 |
| 104 | 21/0 | 7q- | 32/0 | 146/54 | 6/10 |
| 108 | NA | -7 | 20/2 | NA | 8/8 |
| 114 | 28/0 | 7q- | 16/12 | 138/62 | 9/7 |
| 117 | 25/0 | 7q- | 19/6 | 147/53 | 2/13 |
| 128 | 20/0 | -7 | 30/0 | 180/20 | 6/8 |
| 154 | 36/0 | 7q- | 24/1 | 145/55 | 6/7 |
| 160 | 27/0 | 5q- | 6/23 | 94/106 | 6/13 |
| 165 | 29/0 | 7q- | 27/0 | 192/8 | 9/10 |
NA indicates not applicable.