Parameters associated with iron overload in L1-treated patients
Parameters . | Initial values . | Final values . | % change . | t1/2 decay, mo, range . | tmax decay, mo, range . |
|---|---|---|---|---|---|
| Liver iron, mg/g | 23.7 ± 4.3 | 11.4 ± 3.4 | -52* | NA | NA |
| SI, μM | 37 ± 19 | 36 ± 16 | 0 | NA | NA |
| Tf sat. % | 109 ± 23 | 107 ± 33 | 0 | NA | NA |
| SF, ng/mL | 3352 ± 343 | 899 ± 599 | -73* | 4-6 | 10-12 |
| RBCM iron, nmol/mg | 37.2 ± 2.6 | 8.0 ± 1.5 | -78* | 3-5 | 10-12 |
| LPI, μM | 5.1 ± 0.5 | 2.2 ± 0.2 | -57* | 2-3 | 5-7 |
| DCI, μM | 5.4 ± 0.6 | 2.8 ± 0.2 | -49* | 2-3 | 5-7 |
| EPO, U/L | 164 ± 43 | 264 ± 54 | 61* | NA | NA |
| Hb level, g/L | 66 ± 11 | 74 ± 11 | 12† | NA | NA |
Parameters . | Initial values . | Final values . | % change . | t1/2 decay, mo, range . | tmax decay, mo, range . |
|---|---|---|---|---|---|
| Liver iron, mg/g | 23.7 ± 4.3 | 11.4 ± 3.4 | -52* | NA | NA |
| SI, μM | 37 ± 19 | 36 ± 16 | 0 | NA | NA |
| Tf sat. % | 109 ± 23 | 107 ± 33 | 0 | NA | NA |
| SF, ng/mL | 3352 ± 343 | 899 ± 599 | -73* | 4-6 | 10-12 |
| RBCM iron, nmol/mg | 37.2 ± 2.6 | 8.0 ± 1.5 | -78* | 3-5 | 10-12 |
| LPI, μM | 5.1 ± 0.5 | 2.2 ± 0.2 | -57* | 2-3 | 5-7 |
| DCI, μM | 5.4 ± 0.6 | 2.8 ± 0.2 | -49* | 2-3 | 5-7 |
| EPO, U/L | 164 ± 43 | 264 ± 54 | 61* | NA | NA |
| Hb level, g/L | 66 ± 11 | 74 ± 11 | 12† | NA | NA |
The table depicts the initial and final values of parameters associated with iron overload in 14 patients who completed a course of 13 to 17 months of treatment with L1 (50 mg/kg daily doses). The figures were taken from the analyses presented in Figures 2, 3, 4 and are depicted as mean ± SEM. The tmax decay indicates the time required to reach the lowest steady level for a given parameter; t1/2, the decay time to reach the half-maximum change; SI, total serum iron; Tf sat. %, percent transferrin saturation; and NA, nonapplicable.
P < .01.
No statistical significance.