Table 1.

Expression and functional characteristics of tetraspanins in immature DCs



Expression

Effect of Mab binding
Tetraspanin
Surface
Cytoplasm
Translocation
Migration
CD9   ++*  No   No   ↑  
CD63   ++*  Yes   Yes   ↑  
CD81   ++*  +/−  No   ↑  
CD82   +  Yes   Yes   ↑  
CD151
 
+/−
 
No
 
No
 
=
 


Expression

Effect of Mab binding
Tetraspanin
Surface
Cytoplasm
Translocation
Migration
CD9   ++*  No   No   ↑  
CD63   ++*  Yes   Yes   ↑  
CD81   ++*  +/−  No   ↑  
CD82   +  Yes   Yes   ↑  
CD151
 
+/−
 
No
 
No
 
=
 
*

More than 90% labeled cells with an MFI range of 53 to 91.

35% labeled cells with a low MFI of 16.

70% labeled cells with an intermediate MFI of 27.

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