Univariate analysis of cumulative incidence of TRM at one year
. | Cumulative incidence, % . | 95% CI for cumulative incidence, % . | P . | Hazard ratio . | 95% CI for hazard ratio . |
|---|---|---|---|---|---|
| HLA-identical sibling | .001* | ||||
| Wild type (55) | 14 | 18-42 | NA | 1.0 | |
| R pos (9) | 74 | 49-100 | .000 | 7.9 | 2.6-24.0 |
| D pos (6) | 58 | 27-100 | .022 | 4.9 | 1.3-18.9 |
| R & D pos (8) | 75 | 50-100 | .004 | 6.4 | 1.8-23.0 |
| Matched unrelated donor | .04* | ||||
| Wild type (61) | 28 | 18-42 | NA | 1.0 | |
| R pos (13) | 34 | 14-73 | NS | 1.1 | 0.4-3.3 |
| D pos (9) | 56 | 31-100 | NS | 2.4 | 0.9-6.5 |
| R & D pos (4) | 75 | 43-100 | .01 | 4.2 | 1.4-12.5 |
. | Cumulative incidence, % . | 95% CI for cumulative incidence, % . | P . | Hazard ratio . | 95% CI for hazard ratio . |
|---|---|---|---|---|---|
| HLA-identical sibling | .001* | ||||
| Wild type (55) | 14 | 18-42 | NA | 1.0 | |
| R pos (9) | 74 | 49-100 | .000 | 7.9 | 2.6-24.0 |
| D pos (6) | 58 | 27-100 | .022 | 4.9 | 1.3-18.9 |
| R & D pos (8) | 75 | 50-100 | .004 | 6.4 | 1.8-23.0 |
| Matched unrelated donor | .04* | ||||
| Wild type (61) | 28 | 18-42 | NA | 1.0 | |
| R pos (13) | 34 | 14-73 | NS | 1.1 | 0.4-3.3 |
| D pos (9) | 56 | 31-100 | NS | 2.4 | 0.9-6.5 |
| R & D pos (4) | 75 | 43-100 | .01 | 4.2 | 1.4-12.5 |
Univariate analysis of cumulative incidence of TRM at one year in patient/donor pairs with unmutated NOD2/CARD15 SNPs (wild type) versus pairs with either recipient (R pos) or donor mutations (D pos) or mutations in both (R & D pos). Separate analyses were performed for HLA-identical sibling transplantation and matched unrelated donor transplantations. Comparison between groups was performed using log-rank analysis.
CI indicates confidence interval; NA, not applicable; and NS, not significant.
Overall P value