Table 1. Candidate MHC class I and II... | American Society of Hematology

Table 1.

Candidate MHC class I and II binding V_H peptides

Position	Residues	Name	Predicted MHC restriction*	Parker/Rammensee score	Sequence	Position	Germ line
105	9	D9L	K^d	2400/28	DYWGQGTTL	CDR3/Fr4	No
			L^d	5/11
79	9	A9T	K^d	144/13	AYMQLNSLT	Fr3	Yes
43	9	K9I	K^d	115/16	KSLEWIGDI	Fr2/CDR2	Yes
			L^d	5/14
94	9	Y9Y	K^d	60/10	YYCARDRFY	Fr3/CDR3	No
78	9	T9L	K^d	48/13	TAYMQLNSL	Fr3	Yes
			L^d	5/12
75	9	S9L	K^d	40/16	SSSTAYMQL	Fr3	Yes
			L^d	30/20
63	9	K9T	K^d	29/18	KFKGKATLT	CDR2/Fr3	Yes
52	9	N9Y	L^d	78/13	NPNNGGTSY	CDR2	Yes
1	16	E16A	IA^d	P	EVQLQQSGPELVKPGA	L/Fr1	Yes
8	16	G16K	IA^d	P	GPELVKPGASVKMSCK	L/Fr1	Yes
29	17	F17L	IE^d	P	FTDYYMKWVKQSHGKSL	Fr1/CDR1/Fr2	Yes
56	15	G15L	IE^d	P	GGTSYNQKFKGKATL	CDR2/Fr3	Yes
65	16	K16Y	IA^d	P	KGKATLTVDKSSSTAY	Fr3	Yes
79	15	A15V	IA^d	P	AYMQLNSLTSEDSAV	Fr3	Yes

Position	Residues	Name	Predicted MHC restriction*	Parker/Rammensee score	Sequence	Position	Germ line
105	9	D9L	K^d	2400/28	DYWGQGTTL	CDR3/Fr4	No
			L^d	5/11
79	9	A9T	K^d	144/13	AYMQLNSLT	Fr3	Yes
43	9	K9I	K^d	115/16	KSLEWIGDI	Fr2/CDR2	Yes
			L^d	5/14
94	9	Y9Y	K^d	60/10	YYCARDRFY	Fr3/CDR3	No
78	9	T9L	K^d	48/13	TAYMQLNSL	Fr3	Yes
			L^d	5/12
75	9	S9L	K^d	40/16	SSSTAYMQL	Fr3	Yes
			L^d	30/20
63	9	K9T	K^d	29/18	KFKGKATLT	CDR2/Fr3	Yes
52	9	N9Y	L^d	78/13	NPNNGGTSY	CDR2	Yes
1	16	E16A	IA^d	P	EVQLQQSGPELVKPGA	L/Fr1	Yes
8	16	G16K	IA^d	P	GPELVKPGASVKMSCK	L/Fr1	Yes
29	17	F17L	IE^d	P	FTDYYMKWVKQSHGKSL	Fr1/CDR1/Fr2	Yes
56	15	G15L	IE^d	P	GGTSYNQKFKGKATL	CDR2/Fr3	Yes
65	16	K16Y	IA^d	P	KGKATLTVDKSSSTAY	Fr3	Yes
79	15	A15V	IA^d	P	AYMQLNSLTSEDSAV	Fr3	Yes

Position is the amino acid position of the V_H sequence at which the peptides begin. Residues are the number of amino acids in the peptide. CDR indicates complementarity determining region; L, leader; and Fr, framework region. The Parker scores are estimated half-times of dissociation of the peptide from the MHC allele in minutes.⁴¹ The Rammensee scores are based on the relative contribution of amino acid residues and position on MHC binding.⁴² P indicates peptides selected using published binding motifs for MHC class II peptide-binding predictions.⁴³

The MHC allele corresponding to the predicted binding score of Parker, Rammensee, or published motifs.

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