Forced dimerization of tyrosine kinases and transcription factors associated with various human malignancies
. | Molecular abnormality . | Disease subtype . |
|---|---|---|
| Chimeric fusions | ||
| Tyrosine kinases | BCR-ABL | CML, ALL |
| BCR-FGFR1 | CML | |
| TEL-ABL | ALL | |
| TEL-PDGFRβ | CMML | |
| FIP1L1-PDGFRα | Hypereosinophilic syndrome, chronic eosinophilic leukemia | |
| FOP-FGFR1 | EMS or stem cell leukemia lymphoma syndrome | |
| ZNF198-FGFR1 | EMS or stem cell leukemia lymphoma syndrome | |
| CEP110-FGFR1 | EMS or stem cell leukemia lymphoma syndrome | |
| NPM-ALK | Non-Hodgkin lymphoma | |
| Transcription factors | ||
| AML1-ETO | AML-M2 | |
| AML1-MTG16 | AML, MDS | |
| TEL-AML1 | ALL | |
| CBFβ-SMMHC | AML-M4eo | |
| NPM-RARα | AML-M3 | |
| PML-RARα | AML-M3 | |
| PLZF-RARα | AML-M3 | |
| NuMA-RARα | AML-M3 | |
| Stat5b-RARα | AML-M3 | |
| MLL-GAS7 | AML | |
| MLL-AF1p | AML | |
| Subset of MLL fusions | AML, ALL, ABL |
. | Molecular abnormality . | Disease subtype . |
|---|---|---|
| Chimeric fusions | ||
| Tyrosine kinases | BCR-ABL | CML, ALL |
| BCR-FGFR1 | CML | |
| TEL-ABL | ALL | |
| TEL-PDGFRβ | CMML | |
| FIP1L1-PDGFRα | Hypereosinophilic syndrome, chronic eosinophilic leukemia | |
| FOP-FGFR1 | EMS or stem cell leukemia lymphoma syndrome | |
| ZNF198-FGFR1 | EMS or stem cell leukemia lymphoma syndrome | |
| CEP110-FGFR1 | EMS or stem cell leukemia lymphoma syndrome | |
| NPM-ALK | Non-Hodgkin lymphoma | |
| Transcription factors | ||
| AML1-ETO | AML-M2 | |
| AML1-MTG16 | AML, MDS | |
| TEL-AML1 | ALL | |
| CBFβ-SMMHC | AML-M4eo | |
| NPM-RARα | AML-M3 | |
| PML-RARα | AML-M3 | |
| PLZF-RARα | AML-M3 | |
| NuMA-RARα | AML-M3 | |
| Stat5b-RARα | AML-M3 | |
| MLL-GAS7 | AML | |
| MLL-AF1p | AML | |
| Subset of MLL fusions | AML, ALL, ABL |
BCR-ABL indicates breakpoint-cluster region-Abelson leukemia; FGFR1, fibroblast growth factor receptor 1; PDGFRβ, platelet-derived growth factor receptor β; CML, chronic myeloid leukemia; ALL, acute lymphocytic leukemia; CMML, chronic myelomonocytic leukemia; EMS, 8p11 myeloproliferative syndrome.