Features of huMab VN18
Effect of huMab VN18 on: . | Recognition . | Adhesion . | Aggregation . |
|---|---|---|---|
| Purified plasma-derived VN | No | — | — |
| Purified plasma-derived VN, treated with urea | Yes | — | — |
| Purified serum-derived VN17 | Yes | — | — |
| Fibrin clot composed of Fbg | — | = | — |
| Fibrin clot composed of Fbg and multimeric VN | No | ↓ | — |
| Plasma-derived clot | No | ↓ | — |
| VN on ADP-treated platelets | Yes | — | ↓ |
| VN on thrombin-treated platelets | Yes | — | — |
| TRAP-treated platelets | — | — | ↓ |
| Collagen-treated platelets | — | — | ↓ |
Effect of huMab VN18 on: . | Recognition . | Adhesion . | Aggregation . |
|---|---|---|---|
| Purified plasma-derived VN | No | — | — |
| Purified plasma-derived VN, treated with urea | Yes | — | — |
| Purified serum-derived VN17 | Yes | — | — |
| Fibrin clot composed of Fbg | — | = | — |
| Fibrin clot composed of Fbg and multimeric VN | No | ↓ | — |
| Plasma-derived clot | No | ↓ | — |
| VN on ADP-treated platelets | Yes | — | ↓ |
| VN on thrombin-treated platelets | Yes | — | — |
| TRAP-treated platelets | — | — | ↓ |
| Collagen-treated platelets | — | — | ↓ |
— indicates not analyzed; =, no effect; and ↓, inhibition.