The T-cell receptor repertoire of the CMV-specific CD8+ CTL response in healthy seropositive donors is diverse
Donor no. (HLA type) . | No. of CTL clones . | Specificity . | HLA-restricting allele . | T-cell receptor Vβ family . |
|---|---|---|---|---|
| 1 (HLA A3/B7,35) | ||||
| 11 | Undefined | A3 | Vβ6, 8, 22 | |
| 8 | Undefined | B7 | Vβ4, 6, 7, 11, 12 | |
| 7 | Undefined | B35 | Vβ8, 11, 18 | |
| 5 | pp65 | B7 | Vβ8 | |
| 4 | IE-1 | B7 | Vβ21 | |
| 2 (HLA A2, 11/B7,18) | ||||
| 13 | Undefined | B7 | Vβ2, 4, 6, 12 | |
| 5 | Undefined | A11 | Vβ1, 4, 6, 12 | |
| 4 | pp65 | B7 | Vβ4 | |
| 5 (HLA A2,11/B14,44) | ||||
| 7 | Undefined | B44 | Vβ3, 17 | |
| 2 | Undefined | B14 | Vβ22 | |
| 3 | Undefined | Not determined | Vβ5 | |
| 3 | pp65 | A2 | Vβ8 | |
| 2 | pp65 | B44 | Vβ17 |
Donor no. (HLA type) . | No. of CTL clones . | Specificity . | HLA-restricting allele . | T-cell receptor Vβ family . |
|---|---|---|---|---|
| 1 (HLA A3/B7,35) | ||||
| 11 | Undefined | A3 | Vβ6, 8, 22 | |
| 8 | Undefined | B7 | Vβ4, 6, 7, 11, 12 | |
| 7 | Undefined | B35 | Vβ8, 11, 18 | |
| 5 | pp65 | B7 | Vβ8 | |
| 4 | IE-1 | B7 | Vβ21 | |
| 2 (HLA A2, 11/B7,18) | ||||
| 13 | Undefined | B7 | Vβ2, 4, 6, 12 | |
| 5 | Undefined | A11 | Vβ1, 4, 6, 12 | |
| 4 | pp65 | B7 | Vβ4 | |
| 5 (HLA A2,11/B14,44) | ||||
| 7 | Undefined | B44 | Vβ3, 17 | |
| 2 | Undefined | B14 | Vβ22 | |
| 3 | Undefined | Not determined | Vβ5 | |
| 3 | pp65 | A2 | Vβ8 | |
| 2 | pp65 | B44 | Vβ17 |