Table 2.

Adverse events in patients with MF/SS treated with alemtuzumab


Patient no.

Cardiac risks


EF, %

Previously received ANTH

Died within 30 d of discontinuing alemtuzumab
Adverse event(s)
Before
During
After
1   —   Atrial fibrillation   —   55   —   No   No  
2   —   CHF/LV dysfunction, ventricular tachycardia   60   29   39   Yes   No  
3   CAD   Anasarca/infection   —   50   —   No   Yes  
4   HTN   Infection   —   55   —   Yes   Yes  
5   —   CHF/infection   —   55   —   No   No  
6   —   CHF/LV dysfunction   60   20   55   No   No  
7*   HTN   Profound hypotension   60   —   —   No   Yes  
8*
 
HTN/DM
 
CHF/LV dysfunction
 
59
 
15
 
30
 
Yes
 
No
 

Patient no.

Cardiac risks


EF, %

Previously received ANTH

Died within 30 d of discontinuing alemtuzumab
Adverse event(s)
Before
During
After
1   —   Atrial fibrillation   —   55   —   No   No  
2   —   CHF/LV dysfunction, ventricular tachycardia   60   29   39   Yes   No  
3   CAD   Anasarca/infection   —   50   —   No   Yes  
4   HTN   Infection   —   55   —   Yes   Yes  
5   —   CHF/infection   —   55   —   No   No  
6   —   CHF/LV dysfunction   60   20   55   No   No  
7*   HTN   Profound hypotension   60   —   —   No   Yes  
8*
 
HTN/DM
 
CHF/LV dysfunction
 
59
 
15
 
30
 
Yes
 
No
 

EF indicates ejection fraction; ANTH, anthracyclines; —, not done; CHF, congestive heart failure; LV, left ventricular; CAD, coronary artery disease; HTN, hypertension; and DM, diabetes mellitus.

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