Factors associated with overall survival
Patient and treatment-related variables . | No. of patients (no. of deaths) . | Median survival, wk . | Univariate P . | HR . | 95% CI for HR . | Multivariate P . | HR . | 95% CI for HR . |
|---|---|---|---|---|---|---|---|---|
| Recipient-donor CMV | ||||||||
| Negative-negative | 12 (7) | 57 | — | 1.00 | — | |||
| Other | 82 (58) | 30 | .45 | 1.35 | 0.62-2.97 | |||
| Recipient age, y | .58 | 1.01 | 0.98-1.03 | |||||
| 57 or younger | 47 (30) | 42 | — | 1.00 | — | — | 1.00 | — |
| Older than 57 | 47 (35) | 29 | .33 | 1.27 | 0.78-2.07 | .52 | 0.83 | 0.46-1.48 |
| Donor-recipient sex | ||||||||
| Female-female | 26 (19) | 33 | — | 1.00 | — | |||
| Female-male | 20 (16) | 19 | .44 | 1.30 | 0.66-2.55 | |||
| Male-female | 23 (14) | 26 | .65 | 0.85 | 0.42-1.71 | |||
| Male-male | 25 (16) | 52 | .55 | 0.81 | 0.42-1.59 | |||
| Duration of first CR | ||||||||
| Less than 6 mo | 70 (47) | 33 | — | 1.00 | — | |||
| 6-12 mo | 14 (12) | 21 | .14 | 1.62 | 0.86-3.07 | |||
| More than 12 mo | 10 (6) | 169 | .22 | 0.59 | 0.25-1.39 | |||
| Cytogenetics | ||||||||
| Bad | 53 (41) | 20 | — | 1.00 | — | 1.00 | — | |
| Intermediate | 38 (22) | 136 | <.01 | 0.49 | 0.29-0.82 | .08 | 0.61 | 0.36-1.05 |
| Missing | 3 (2) | 13 | — | — | — | — | — | |
| Disease status | ||||||||
| First CR | 11 (5) | 209 | — | 1.00 | — | — | 1.00 | — |
| More than 1 CR | 13 (5) | — | .61 | 0.73 | 0.21-2.51 | .79 | 0.84 | 0.24-3.00 |
| Refractory | 57 (46) | 21 | .04 | 2.71 | 1.07-6.85 | .02 | 3.29 | 1.19-9.15 |
| Untreated | 13 (9) | 26 | .16 | 2.21 | 0.74-6.61 | .04 | 3.85 | 1.08-13.81 |
| Preparative regimen | ||||||||
| FAI | 32 (22) | 40 | — | 1.00 | — | — | 1.00 | — |
| FM | 62 (43) | 30 | .79 | 1.07 | 0.64-1.80 | .06 | 0.48 | 0.23-1.02 |
| Cell type | ||||||||
| Bone marrow | 41 (30) | 32 | — | 1.00 | — | |||
| Peripheral blood | 53 (35) | 34 | .67 | 0.90 | 0.55-1.47 | |||
| Time from diagnosis to transplantation | 96 | NA | .18 | 1.00 | 0.99-1.00 | |||
| ABO mismatch | ||||||||
| No | 56 (35) | 34 | — | 1.00 | — | |||
| Yes | 37 (29) | 30 | .16 | 1.42 | 0.88-2.33 | |||
| Matched sibling | ||||||||
| No | 43 (31) | 23 | — | 1.00 | — | — | 1.00 | — |
| Yes | 51 (34) | 40 | .40 | 0.81 | 0.50-1.32 | .1 | 0.60 | 0.33-1.05 |
Patient and treatment-related variables . | No. of patients (no. of deaths) . | Median survival, wk . | Univariate P . | HR . | 95% CI for HR . | Multivariate P . | HR . | 95% CI for HR . |
|---|---|---|---|---|---|---|---|---|
| Recipient-donor CMV | ||||||||
| Negative-negative | 12 (7) | 57 | — | 1.00 | — | |||
| Other | 82 (58) | 30 | .45 | 1.35 | 0.62-2.97 | |||
| Recipient age, y | .58 | 1.01 | 0.98-1.03 | |||||
| 57 or younger | 47 (30) | 42 | — | 1.00 | — | — | 1.00 | — |
| Older than 57 | 47 (35) | 29 | .33 | 1.27 | 0.78-2.07 | .52 | 0.83 | 0.46-1.48 |
| Donor-recipient sex | ||||||||
| Female-female | 26 (19) | 33 | — | 1.00 | — | |||
| Female-male | 20 (16) | 19 | .44 | 1.30 | 0.66-2.55 | |||
| Male-female | 23 (14) | 26 | .65 | 0.85 | 0.42-1.71 | |||
| Male-male | 25 (16) | 52 | .55 | 0.81 | 0.42-1.59 | |||
| Duration of first CR | ||||||||
| Less than 6 mo | 70 (47) | 33 | — | 1.00 | — | |||
| 6-12 mo | 14 (12) | 21 | .14 | 1.62 | 0.86-3.07 | |||
| More than 12 mo | 10 (6) | 169 | .22 | 0.59 | 0.25-1.39 | |||
| Cytogenetics | ||||||||
| Bad | 53 (41) | 20 | — | 1.00 | — | 1.00 | — | |
| Intermediate | 38 (22) | 136 | <.01 | 0.49 | 0.29-0.82 | .08 | 0.61 | 0.36-1.05 |
| Missing | 3 (2) | 13 | — | — | — | — | — | |
| Disease status | ||||||||
| First CR | 11 (5) | 209 | — | 1.00 | — | — | 1.00 | — |
| More than 1 CR | 13 (5) | — | .61 | 0.73 | 0.21-2.51 | .79 | 0.84 | 0.24-3.00 |
| Refractory | 57 (46) | 21 | .04 | 2.71 | 1.07-6.85 | .02 | 3.29 | 1.19-9.15 |
| Untreated | 13 (9) | 26 | .16 | 2.21 | 0.74-6.61 | .04 | 3.85 | 1.08-13.81 |
| Preparative regimen | ||||||||
| FAI | 32 (22) | 40 | — | 1.00 | — | — | 1.00 | — |
| FM | 62 (43) | 30 | .79 | 1.07 | 0.64-1.80 | .06 | 0.48 | 0.23-1.02 |
| Cell type | ||||||||
| Bone marrow | 41 (30) | 32 | — | 1.00 | — | |||
| Peripheral blood | 53 (35) | 34 | .67 | 0.90 | 0.55-1.47 | |||
| Time from diagnosis to transplantation | 96 | NA | .18 | 1.00 | 0.99-1.00 | |||
| ABO mismatch | ||||||||
| No | 56 (35) | 34 | — | 1.00 | — | |||
| Yes | 37 (29) | 30 | .16 | 1.42 | 0.88-2.33 | |||
| Matched sibling | ||||||||
| No | 43 (31) | 23 | — | 1.00 | — | — | 1.00 | — |
| Yes | 51 (34) | 40 | .40 | 0.81 | 0.50-1.32 | .1 | 0.60 | 0.33-1.05 |
— indicates reference; NA, not applicable.