Influence of ADP-receptor antagonists on HOCI-LDL aggregation
HOCI-LDL . | HOCI-LDL + ADP . | HOCI-LDL + ADP + AR-C69931 . | HOCI-LDL + ADP + A2P5P . |
|---|---|---|---|
| 26.5 ± 6.8 | 80.3 ± 4.6 | 37.4 ± 7.4 | 19.7 ± 6.0 |
HOCI-LDL . | HOCI-LDL + ADP . | HOCI-LDL + ADP + AR-C69931 . | HOCI-LDL + ADP + A2P5P . |
|---|---|---|---|
| 26.5 ± 6.8 | 80.3 ± 4.6 | 37.4 ± 7.4 | 19.7 ± 6.0 |
Washed platelets were exposed to HOCI-LDL alone (20 μg/mL) or to the combination of 1 μM ADP and HOCI-LDL, with or without 10 minutes of preincubation with the ADP receptor antagonists AR-C69931 or A2P5P.52 Aggregation data are expressed as means ± SEs from 3 platelet preparations for the percentage loss of platelet singlets detected by resistive-particle counting.