Patient, disease, and donor characteristics
Patient characteristics . | Values . |
|---|---|
| Median age, y (range) | 45 (19-66) |
| Sex, no. (%) | |
| Male | 48 (50) |
| Female | 48 (50) |
| Disease diagnosis, no. (%) | |
| AML | 74 (77) |
| MDS | 22 (23) |
| RA | 2 |
| RAEB | 13 |
| RAEBt | 5 |
| CMML | 2 |
| Time from diagnosis to transplantation, mo (range) | 11.7 (1.9-87.5) |
| Disease status at transplantation, no. (%) | |
| Remission | 42 (44) |
| Active disease | 54 (56) |
| First CR | 19 (20) |
| Second or subsequent CR | 23 (24) |
| Primary induction failure | 20 (21) |
| First relapse | 21* (22) |
| Second or subsequent relapse | 3 (3) |
| Untreated | 10 (10) |
| Median duration of first CR, mo (range) | 4.5 (0-73.4) |
| PB blasts at transplantation, no. (%) | |
| No | 69 (72) |
| Yes | 27 (28) |
| Cytogenetics, no. (%) | |
| Good prognosis | 3 (3) |
| Standard risk | 65 (68) |
| Poor prognosis | 28 (29) |
| CMV+ recipients, no. (%) | 77 (80) |
| Donor characteristics, no. (%) | |
| HLA-identical sibling | 56 (55) |
| HLA-identical related | 2 (1) |
| Matched unrelated | 36 (38) |
| Mismatched related | 2 (6) |
Patient characteristics . | Values . |
|---|---|
| Median age, y (range) | 45 (19-66) |
| Sex, no. (%) | |
| Male | 48 (50) |
| Female | 48 (50) |
| Disease diagnosis, no. (%) | |
| AML | 74 (77) |
| MDS | 22 (23) |
| RA | 2 |
| RAEB | 13 |
| RAEBt | 5 |
| CMML | 2 |
| Time from diagnosis to transplantation, mo (range) | 11.7 (1.9-87.5) |
| Disease status at transplantation, no. (%) | |
| Remission | 42 (44) |
| Active disease | 54 (56) |
| First CR | 19 (20) |
| Second or subsequent CR | 23 (24) |
| Primary induction failure | 20 (21) |
| First relapse | 21* (22) |
| Second or subsequent relapse | 3 (3) |
| Untreated | 10 (10) |
| Median duration of first CR, mo (range) | 4.5 (0-73.4) |
| PB blasts at transplantation, no. (%) | |
| No | 69 (72) |
| Yes | 27 (28) |
| Cytogenetics, no. (%) | |
| Good prognosis | 3 (3) |
| Standard risk | 65 (68) |
| Poor prognosis | 28 (29) |
| CMV+ recipients, no. (%) | 77 (80) |
| Donor characteristics, no. (%) | |
| HLA-identical sibling | 56 (55) |
| HLA-identical related | 2 (1) |
| Matched unrelated | 36 (38) |
| Mismatched related | 2 (6) |
RA indicates refractory anemia; RAEB, refractory anemia with excess blasts; RAEBt, refractory anemia with excess blasts in transformation; CMML, chronic myelomonocytic leukemia; CMV, cytomegalovirus.
First relapse: 15 refractory, 6 untreated