QTL identified in young and old BXD RI strains
Trait and Chr* . | Peak LRS interval . | cM, range . | LRS . | High allele . |
|---|---|---|---|---|
| No. LSK cells 8 wk | ||||
| 4 | D4Mit54-D4Mit226 | 66-78.5 | 13.8 | DBA/2 |
| 7 | D7Mit17-D7Mit238 | 51-53 | 13.9 | DBA/2 |
| 2† | D2Mit493-D2Mit411 | 72.1-77.2 | NA | C57BL/6 |
| 16 | D16Mit146-D6Mit58 | 16.9-23.1 | 10.9 | C57BL/6 |
| 14‡ | Broad | Broad | 10.6 | C57BL/6 |
| % LSK cells 8 wk | ||||
| 4 | D4Mit312-D4Mit226 | 69.8-78.5 | 11.4 | DBA/2 |
| 7 | D7Mit17-D7Mit238 | 51-53 | 10.2 | DBA/2 |
| Proliferation 8 wk | ||||
| 2 | D2Mit493-D2Mit411 | 72.1-77.2 | 13.5 | C57BL/6 |
| X§ | NA | NA | NA | DBA/2 |
| No. LSK cells 18 mo | ||||
| 12 | D12Mit112-S12Gnf051.120 | 22-24 | 10.1 | C57BL/6 |
| 4∥ | D4Mit80-D4Mit303 | 37.7-48.5 | 9.8 | C57BL/6 |
| % LSK cells 18 mo | ||||
| 12 | D12Mit112-S12Gnf051.120 | 22-24 | 10.1 | C57BL/6 |
| Proliferation 18 mo | ||||
| 7 | D7Mit78-D7Mit190 | 0.5-2.5 | 14.9 | DBA/2 |
| 2∥ | D2Mit396-D2Mit304 | 69-72 | 13.8 | DBA/2 |
| 9 | D9Mit227-D9Mit4 | 23-27 | 9.2 | DBA/2 |
| Lifespan | ||||
| 2 | D2Mit396-D2Mit304 | 69-72 | 12.2 | DBA/2 |
| 4∥ | D4Mit312-D4Mit344 | 69.8-81.7 | 13.9 | C57BL/6 |
| 4∥ | D4Mit193-D4Mit237 | 7.5-13.3 | 11.5 | DBA/2 |
| X∥ | DXMit10-DXMit223 | 63-73 | 11.3 | DBA/2 |
| 7 | D7Mit178-D7Mit75 | 0.5-1.7 | 14.5 | C57BL/6 |
| 4∥ | D4Mit80-D4Mit303 | 37.7-48.5 | 12.4 | DBA/2 |
| 12∥ | D12Mit136-D12Mit235 | 13-19 | 9.8 | DBA/2 |
Trait and Chr* . | Peak LRS interval . | cM, range . | LRS . | High allele . |
|---|---|---|---|---|
| No. LSK cells 8 wk | ||||
| 4 | D4Mit54-D4Mit226 | 66-78.5 | 13.8 | DBA/2 |
| 7 | D7Mit17-D7Mit238 | 51-53 | 13.9 | DBA/2 |
| 2† | D2Mit493-D2Mit411 | 72.1-77.2 | NA | C57BL/6 |
| 16 | D16Mit146-D6Mit58 | 16.9-23.1 | 10.9 | C57BL/6 |
| 14‡ | Broad | Broad | 10.6 | C57BL/6 |
| % LSK cells 8 wk | ||||
| 4 | D4Mit312-D4Mit226 | 69.8-78.5 | 11.4 | DBA/2 |
| 7 | D7Mit17-D7Mit238 | 51-53 | 10.2 | DBA/2 |
| Proliferation 8 wk | ||||
| 2 | D2Mit493-D2Mit411 | 72.1-77.2 | 13.5 | C57BL/6 |
| X§ | NA | NA | NA | DBA/2 |
| No. LSK cells 18 mo | ||||
| 12 | D12Mit112-S12Gnf051.120 | 22-24 | 10.1 | C57BL/6 |
| 4∥ | D4Mit80-D4Mit303 | 37.7-48.5 | 9.8 | C57BL/6 |
| % LSK cells 18 mo | ||||
| 12 | D12Mit112-S12Gnf051.120 | 22-24 | 10.1 | C57BL/6 |
| Proliferation 18 mo | ||||
| 7 | D7Mit78-D7Mit190 | 0.5-2.5 | 14.9 | DBA/2 |
| 2∥ | D2Mit396-D2Mit304 | 69-72 | 13.8 | DBA/2 |
| 9 | D9Mit227-D9Mit4 | 23-27 | 9.2 | DBA/2 |
| Lifespan | ||||
| 2 | D2Mit396-D2Mit304 | 69-72 | 12.2 | DBA/2 |
| 4∥ | D4Mit312-D4Mit344 | 69.8-81.7 | 13.9 | C57BL/6 |
| 4∥ | D4Mit193-D4Mit237 | 7.5-13.3 | 11.5 | DBA/2 |
| X∥ | DXMit10-DXMit223 | 63-73 | 11.3 | DBA/2 |
| 7 | D7Mit178-D7Mit75 | 0.5-1.7 | 14.5 | C57BL/6 |
| 4∥ | D4Mit80-D4Mit303 | 37.7-48.5 | 12.4 | DBA/2 |
| 12∥ | D12Mit136-D12Mit235 | 13-19 | 9.8 | DBA/2 |
NA indicates not applicable.
All QTL with a suggestive level of genome-wide significance according to permutation analysis are shown.
Significance level below suggestive using webQTL, but confirmed in congenic mice.14
Broad low-suggestive QTL spanning the distal two thirds of chr 14.
Identified in reciprocal D2B6/B6D2 F1 hybrids.
After correction for the preceding major QTL in the table.