SU11657 target profiles
. | Biochemical IC50, μM . | Cell kinase assay cellular IC50, μM . | Ligand-dependent synthesis cellular IC50, μM . |
|---|---|---|---|
| PDGFβR | 0.001 | 0.01-0.1 | 0.01 |
| Flk-1/KDR | 0.01 | 0.005-0.05 | — |
| Flt3-ITD | — | 0.05 | — |
| c-Kit | — | 0.01-0.05 | — |
| EGFR | > 20 | — | 23 |
. | Biochemical IC50, μM . | Cell kinase assay cellular IC50, μM . | Ligand-dependent synthesis cellular IC50, μM . |
|---|---|---|---|
| PDGFβR | 0.001 | 0.01-0.1 | 0.01 |
| Flk-1/KDR | 0.01 | 0.005-0.05 | — |
| Flt3-ITD | — | 0.05 | — |
| c-Kit | — | 0.01-0.05 | — |
| EGFR | > 20 | — | 23 |
IC50 values for SU11657 in selected biochemical and cellular assays are shown. Assays were performed as previously described.7 IC50 indicates concentration that inhibits 50%;—, not determined; and EGFR, epidermal growth factor receptor.